Grace Orstad, PhD

medical writer working remotely from MPLS, MN. alum of @uutah @huntsmancancer and @northernmichu #blacklivesmatter

[Grace Orstad, PhD @graceorstad]

Excited to share that my 1st author paper is out today in @Dev_Cell! Using mouse models, organoids, and human cell lines we have found that pioneer factors FoxA1 and FoxA2 are critical drivers of lung adenocarcinoma growth and transcriptional evolution 1/ https://t.co/aDflpCqyLu

[Grace Orstad, PhD @graceorstad]

@Branmiz25 Strangely a website called Rentler is the major platform used in SLC, way more than Zillow or https://t.co/uyWfF6ui2m in my experience! It’s associated with the KSL classifieds. Lived here for 6 years and have found every apartment on that website!

[Grace Orstad, PhD @graceorstad]

Tomorrow is the big day! I’ll be defending my dissertation at 11AM (MDT) in a hybrid format, so folks can attend via Zoom! Info below 👇🏼

[Grace Orstad, PhD @graceorstad]

@michelson_da @Dev_Cell Thank you! We never manipulated FoxA3 directly because it is not quite as similar in structure/function as FoxA1/2 are. However, Foxa3 transcript levels decrease when we KO Foxa1/2 in organoids. It's expressed in a subset of KP LUAD cells but is mostly lost upon Foxa1/2 deletion!

[Grace Orstad, PhD @graceorstad]

Excited to share that my 1st author paper is out today in @Dev_Cell! Using mouse models, organoids, and human cell lines we have found that pioneer factors FoxA1 and FoxA2 are critical drivers of lung adenocarcinoma growth and transcriptional evolution 1/ https://t.co/aDflpCqyLu

[Developmental Cell @Dev_Cell]

Online now: FoxA1 and FoxA2 control growth and cellular identity in NKX2-1-positive lung adenocarcinoma https://t.co/5QuQ9Pp2gz

[Grace Orstad, PhD @graceorstad]

Overall, we believe this work provides critical insight into the regulation of cancer cell identity that is needed to design therapeutic approaches that integrate actionable oncogenic mutations with differentiation-state-specific vulnerabilities 8/8

[Grace Orstad, PhD @graceorstad]

Mechanistically, loss of FoxA1/2 leads to aberrant NKX2-1 transcriptional activity and genomic localization, which in turn drives the expression of these non-proliferative identities, actively inhibiting growth in FoxA1/2-negative tumors 7/

[Derek Liberti @ChasingLiberti]

Proud to announce our latest @Dev_Cell publication:

Klf5 defines alveolar epithelial type 1 cell lineage commitment during lung development and regeneration

https://t.co/XHJuIjOZjG

[Grace Orstad, PhD @graceorstad]

In my first article last week I summarized very exciting work published in @Nature by @SVanharanta's group beautifully demonstrating the relationship between lineage factors and driver mutations in ccRCC https://t.co/afOdt6CLbG

[Grace Orstad, PhD @graceorstad]

Some exciting ~personal news~: I recently started writing freelance articles for @CD_AACR's #ResearchWatch section! Check out my article for this week's edition about an exciting paper in @ImmunityCP : https://t.co/EjQDzf8GuQ

[Ishwariya Venkatesh @Ishwariya13]

I remember breaking down to my Ph.D. advisor about how stupid I felt while troubleshooting a problem in my project when she handed me this paper. Years later it is still relevant to young students starting off in Science. It's ok to feel stupid, we all do on a regular basis.

[ᐯIᑕTOᖇ ᑎIᘔET @victornizet]

before mRNA synthesis can take place, the DNA double helix must unwind to form the “transcription bubble”

[Sanjee Baksh @S__Baksh]

setting the record straight -- the lungs:
1) make sure your silly little other organs get oxygen
2) regulate your pH
3) control the blood return to your heart
4) regulate blood pressure via ACE
5) yes they get mad at the disrespect and irreversibly fibrose
6) look like this

[Elizabeth McKenna @ElizSMcKenna]

⁦@graceorstad⁩ from ⁦@huntsmancancer⁩ presenting her thesis work on the role of FOXA1/2 in lung cancer at #EMBOCancerEvolution

[Dian Yang @dianyang1117]

Excited to share our work using a CRISPR-based lineage tracer to track tumor evolution from a single transformed cell to an aggressive tumor in a genetically engineered KP-Tracer model. It is a great collaboration of the @JswLab, @LabJacks and @YosefLab.
https://t.co/at5yMZmtlF