Stewart Adams

Think first, then read, then think again, then provide an opinion.

[Afshine Emrani MD FACC @afshineemrani]

I'm a cardiologist. For months I've been telling you that inflammation is the fire behind heart disease — not just cholesterol. That we've been treating the smoke while the fire kept burning.

Penn Medicine just built the fire extinguisher.

They took the most powerful immune technology in cancer medicine — CAR T-cell therapy — and flipped it. Instead of engineering killer cells to destroy tumors, they engineered regulatory T cells to suppress the chronic arterial inflammation that causes heart attacks.
Published in Circulation. The results stopped me cold.
In CAR T cancer therapy, doctors extract your T cells, genetically engineer them to recognize a specific target, and infuse them back into your body as precision-guided missiles. It has cured previously terminal blood cancers. The technology won its developers a Nobel Prize.

The Penn team asked a question no one had asked before: what if we aimed this at the arteries?
They engineered regulatory T cells — Tregs, the immune cells whose job is to calm inflammation rather than cause it — to specifically target oxidized LDL. OxLDL is the molecule that starts the entire atherosclerotic cascade. It infiltrates your artery wall, triggers macrophages to gorge on it and become foam cells, releases inflammatory cytokines, recruits more immune cells, and builds the plaque that eventually ruptures and causes a heart attack.

OxLDL is the match that lights the fire. These engineered CAR Tregs are designed to find that match and snuff it out — at the arterial wall itself.

The results in mouse models of atherosclerosis:
Blocked macrophage foam cell formation — the cellular process that builds plaque. Dramatically reduced arterial wall inflammation. Prevented over 70% of plaque buildup compared to untreated controls. And critically — preserved normal immune function everywhere else.

That last point is essential. Previous anti-inflammatory approaches to atherosclerosis failed because they suppressed the entire immune system — leaving patients vulnerable to infections and other complications. Colchicine works modestly. Canakinumab in the CANTOS trial reduced events but increased fatal infections. The immune system is a sledgehammer. You can't just turn it down globally.
CAR Tregs solve this by being targeted. They don't suppress your whole immune system. They patrol your arteries specifically, calming the inflammation at the exact site where it's causing damage — and leaving the rest of your immunity intact.

One infusion. Targeted. Precise. The cells do the work.
Lead author Robert Schwab of Penn Medicine put it directly: "If we can get the immune system to see OxLDL and provoke an anti-inflammatory response, it would reduce inflammation and essentially stop the pathogenesis in its tracks."

Senior author Avery Posey: "Our study shows for the first time how CAR T cell technology could be used to treat the underlying cause of the most common form of heart disease — the leading cause of death worldwide."
As a cardiologist who has spent twenty years treating the downstream consequences of arterial inflammation — the stents, the bypasses, the cardiac rehab, the second heart attacks — I need you to understand what this represents.

Every treatment I currently have manages the damage after the fire has burned. Statins lower the fuel supply. Blood pressure meds reduce the mechanical stress. Stents prop open arteries that have already narrowed. These save lives. I use them daily.
But none of them put out the fire itself.
CAR Tregs are engineered to extinguish the inflammation at its source — inside the artery wall — before the plaque builds, before the vessel narrows, before the rupture, before the heart attack.
This is the shift from managing disease to correcting the biological process that causes it. At the cellular level. With living medicine.

This was demonstrated in mice, not humans. The leap from mouse models to human cardiovascular trials is enormous and filled with failures. Manufacturing CAR T cells is currently expensive — roughly $400,000 per treatment in cancer. Scaling this for a disease that affects billions would require a manufacturing revolution. Long-term safety of engineered immune cells patrolling human arteries for years or decades is completely unknown. Human trials are likely years away.
But 70% plaque reduction. With preserved immune function. Targeting the exact inflammatory mechanism I've been writing about for months. Published in Circulation — the flagship journal of the American Heart Association.
The trajectory is unmistakable.
Gene editing to permanently lower cholesterol. Personalized mRNA vaccines to hunt cancer. GLP-1 drugs rewiring metabolism. Cellular reprogramming to reverse aging. And now ��� living immune cells engineered to extinguish the inflammation that causes the number one killer on earth.
Every one of these treats the root cause instead of managing the downstream damage. Every one of them was impossible a decade ago. Every one of them is in trials or approaching trials right now.
I've held dying hearts in my hands in the cath lab at 3 AM. Hearts that were destroyed by inflammation I could see but couldn't stop.
The day I can infuse a patient with cells engineered to stop that inflammation before it ever builds the plaque — that's the day cardiology changes forever.
We're not there yet. But the fire extinguisher just passed its first test.

[Stewart Adams @GrunkleStew2022]

@TeslaLarry @seandsweeney @elonmusk If Elon had spare cycles he could focus on Precision Fermentation to bring the cost down, then pair it with solar power and batteries all on shipping containers that could be installed anywhere.

[David Sinclair @davidasinclair]

After 25 years of brave & brilliant work by hundreds of scientists in my lab to understand then safely reverse aging for the first time, it was moving to witness the first human dose being delivered 🥹 https://t.co/veQsyUEORz

[Stewart Adams @GrunkleStew2022]

@surfranchvibes I sold my 2020 Y AWD in 2024 and moved to Panama, where there is very little Tesla support. We drove from Calgary to Panama with poor charging options, so I sold the Tesla and bought a top of the line 2025 Hyundai Santa Fe.

I miss the Y every time I drive the dinosaur car😥

[Stewart Adams @GrunkleStew2022]

@Teslarati I got a model Y in 2020 in Alberta Canada and traveled to Northern Saskatchewan often before charging infrastructure was there. I've driven from Calgary to Florida and Calgary to Houston both times in the winter. More range would have been great.

[Bryan Johnson @bryan_johnson]

This is it.
Everything learned spending millions on longevity.

From: Your Immortal Unc and Auntie.
To: Our Immortal nieces and nephews.

0. Sleep is the world's most powerful drug.
1. Be in your bed for 8 hours
2. Same bedtime every night, any time before midnight
3. Don’t eat right before bed
4. Calm foods for dinner
5. No screens 1 hour before bed
6. Avoid added sugar (be aware it’s in everything)
7. Avoid all things in an American convenience store
8. Avoid fried foods
9. Shoes off at the door
10. Eat whole foods, particularly veggies fruits nuts legumes berries
11. Walk a little after meals or air squats
12. Get your heart rate high routinely
13. Lift heavy things
14. Stretch daily
15. Water pik, floss, brush, tongue scrape, morning and night
16. Make an effort to drink water
17. Get sunlight when you wake up (UV is low)
18. Protect skin in midday sun
19. Stand up straight
20. See at least one friend once a week
21. Avoid plastic where you can (in all things)
22. Circulate air in rooms
23. When stressed, breathe, learn to calm your body
24. Go to the dentist
25. Avoid sitting for long times
26. Protect your hearing, the world is too loud
27. Alcohol is bad for you
28. Finish coffee before noon
29. Avoid bright lights after sunset
30. If obese, look into a GLP
31. Sleep in a cold room
32. Texting while driving is dangerous
33. Turn off all notifications
34. Limit social media use
35. Don’t smoke anything
36. If you struggle to sleep, read a physical book before bed
37. 1 hour before bed have a calm wind down routine: bath, read, light walk, listen to music
38. The body is a clock and loves routine. Have a daily morning and evening schedule.
39. Avoid long distance travel where you can
40. Baby steps first: incorporate new things slowly
41. Do less… most things don’t work.

Bonus points if you get your blood checked.

Start here, it will change your life.

[NASA Administrator Jared Isaacman @NASAAdmin]

@MattGialich I love Dragonfly..An autonomous ~1,000-pound, radioisotope-powered octocopter flying for years in −290°F temps on Titan is exactly the kind of near-impossible science mission NASA exists to achieve.

[Johnny Brown @johnnyxbrown]

I've regretted skipping the gym, drinking alcohol, and staying up late more times than I can count.

But I've never regretted lifting weights, drinking water, or going to bed early.

If you want to get healthy, start with the habits that will never let you down.

[Cern Basher @CernBasher]

https://t.co/enys8L5ifS

[Dr Singularity @Dr_Singularity]

I don’t fear time passing (fast) anymore. With today's science and tech levels (and constant acceleration), every year feels less like aging and more like approaching the 'reset button.'

By the 2030s, aging reversal tech should let us basically start all over again, no matter how old you are.

And aging reversal will be just one thing, countless other technologies will make our lives 1000s of times better, more enjoyable, and more interesting than today.

[cbcwatcher @cbcwatcher]

Boom! "If we had built Northern Gateway, if we built Keystone and we built Energy east, we'd have 2.5 million barrels more per day of production, which is $55 billion a year worth of GDP value, which is worth $17 billion to my government alone and about an equal amount to the federal government. This is not just an ideological argument."

"It's not just a minor disagreement."

"Oil is by far the most valuable export for Canada."

"Any of the projects that you have that you will see on the ultimate list, I will tell you that a bitumen pipeline will be by far the greatest benefit to all of Canada."

"There's $9 trillion worth of value in discoverable and achievable reserves right now."

"And so why would you leave that in the ground?"
@ABDanielleSmith

[Stewart Adams @GrunkleStew2022]

@stats_feed It's damn cold in January. Nothing else to do.

[Stewart Adams @GrunkleStew2022]

https://t.co/23rKinin4Z

[Pierre Poilievre @PierrePoilievre]

Canada is worth fighting for.

[Bryan Johnson @bryan_johnson]

People accused me of lying and cherry picking.

I posted receipts showing that I have the world's best biomarkers.

I've demonstrated at age 47, you can:
+ slow your speed of aging by 50%
+ have the fertility health of a 20 year old
+ telomeres that are age 10
+ bone mineral density top 99.8%
+ cardiovascular fitness top 85th percentile of 18 yr olds
+ have zero detectable systematic inflammation
+ maintain high testosterone without TRT
+ achieve consistent high quality sleep
+ maintain 60+ ideal biomarkers predictive of all-cause mortality

A new category is here. We've had the world's fastest and richest. Now most healthy.

Don't Die is the new game of existence. I'm trying to show the world how to play this new game. Our current cultural norms make us sick, miserable and increase our risk of extinction even though they're sold as happiness and meaning.

I've demonstrated the best way to improve health is through measurement paired with the usage of scientific evidence.

It took me years of efforts to achieve these results, being meticulous with everything that interfaces with my body and mind including air, water, food, sleep, exercise, toxins, community, information, and beliefs.

It lead me to source and manufacture my own food and supplements to enable the same methodical iterative improvements as my protocols and build a platform to test toxins in the world's food supply (coming soon).

If you don't see the wisdom of Don't Die, you'll see it in the coming years when AI progress dislocates existing norms and structures and creates a gaping hole for practical and existential daily human existence. Don't Die will fill that need to provide stability, structure and purpose.

We need games to play, purpose to pursue, and hard things to accomplish.

I've demonstrated Don't Die for human health and well-being. You are invited to build it in your domain: AI, politics, education, health care, law, cultural norms, international relations, agriculture, entertainment, material science, etc.

Don't Die is humanity's next frontier.

[Bryan Johnson @bryan_johnson]

Here is a simplified way to approach health:

Don’t Die Protocol
Mastering your resting heart rate

Over five years I evolved from obese, depressed, and inflamed to arguably having the best comprehensive biomarkers in the world. It feels amazing. You do not need to do what I do to achieve exceptional health. It’s much easier than you think.

Foundational building blocks
+ Your body is in charge, not your mind.
+ Systems and habits rule your life, not in-the-moment decisions.
+ Existence is the highest virtue.

I’m going to help you simplify the chaos of health into something very simple.

I’ve become the most measured person in history and of all the things I measure, there is one marker that I value above them all:

resting heart rate before bed.

Why? Because it tells the truth.

It reflects your nervous system, your habits, your food, your stress, your sleep, your life.

​​It’s the single most powerful, real-time indicator of how your system is performing.

Lower RHR is a longer life, better sleep, calmer mind, stronger body.

Step One: Measure It
Tonight, before bed, measure your RHR:

+ Use a wearable device (e.g. Oura, Whoop, Apple Watch), or

+ Place two fingers on your neck, count beats for 6 seconds, and multiply by 10.

Let’s say it’s 60 bpm.

Your objective over the next 30 days: lower it by 10% → to 54 bpm.

Your entire life now orients around this single metric.

Here is a sample day:

4:30–5:00 AM — Wake up naturally
5:00 AM — Light in the eyes
5:30 AM — Pre-workout fuel
6:00 AM — 1-hour workout (strength, cardio, balance, flexibility)
7:30 AM — Breakfast
8:00 AM–12:00 PM — Deep work
12:00 PM — Lunch
1:00–5:30 PM — Focused work
5:30–6:00 PM — Final meal of the day
9:00 PM — Wind down. Screens off.
10:00 PM — Asleep.

This works by lowering your RHR.

+ Daily exercise → Strengthens heart, lowers baseline rate.
+ Early dinner → Reduces overnight digestive strain.
+ No screens at night → Calms your nervous system.
+ Wind-down routine → Transitions body into parasympathetic state.

Next Level
Once your schedule is aligned, we eliminate the next obvious enemies:

+ Processed sugar, fried foods, fast food, excessive stimulants

All of these raise your resting heart rate.

You're trying for compounded gains

1. It starts with one win: lower RHR → better sleep. You fall asleep faster. You stay asleep longer. Your body repairs deeper.

2. Better sleep compounds into stronger willpower. You have more strength to make better choices.

3. Stronger willpower compounds into consistent exercise. You move your body, strengthen your heart, and release feel-good chemicals daily. Daily movement compounds into better eating.

4. You crave nutritious food. You recover faster. You stop eating junk. Eating clean compounds into self-respect.

5. You avoid what dulls your edge — sugar, alcohol, late nights, chaos.Compounds right back into an even lower resting heart rate.

Focusing on your resting heart rate before bed helps you overcome your worst habits:

+ bad sleep habits
+ late night binge eating
+ doom scrolling before bed
+ not getting exercise
+ eating bad foods

[Stewart Adams @GrunkleStew2022]

https://t.co/CE6LdgHdd3

[Danielle Smith @ABDanielleSmith]

(1/2) I am disappointed with U.S. President Donald Trump’s @realDonaldTrump decision to place tariffs on all Canadian goods. This decision will harm Canadians and Americans alike, and strain the important relationship and alliance between our two nations.

Alberta will do everything in its power to convince the U.S. President and Congress, as well as the American people, to reverse this mutually destructive policy.

We note the reduced 10% tariff for Canadian energy which is partially a recognition of the advocacy undertaken by our Government and industry to the U.S. Administration pointing out the substantial wealth created in the U.S. by American companies and tens of thousands of American workers that upgrade and refine approximately $100 billion of Canadian crude into $300 billion of product sold all over the world by those same U.S. companies.

It is also worth noting that if oil and gas exports are excluded, the United States actually sells more to Canada than Canada sells to the U.S.. As I’ve stated to every American policymaker I’ve met with these past months, Canada buys more from the U.S. than any country on earth - more than U.K., France, Germany, Italy and Vietnam combined. There is, therefore, no economic justification for tariffs imposed on any Canadian goods.

Alberta will continue our diplomatic efforts in the United States to persuade the U.S. President, lawmakers, Administration officials and the American people to lift all tariffs on Canadian goods as soon as possible and to repair our relationship with the United States. I encourage all Premiers and federal officials to do the same, especially as the effects of these tariffs begin to take their toll south of the border. Americans need to understand the detrimental consequences of this policy decision.

Alberta will also work collaboratively with our federal government and fellow provinces on a proportionate response to the imposed U.S. tariffs through the strategic use of Canadian import tariffs on U.S. goods that are more easily purchased from Canada and non-U.S. suppliers. This will minimize costs to Canadian consumers while creating maximum impact south of the border. All funds raised from such import tariffs should go directly to benefit the Canadians most harmed by the imposed U.S. tariffs.

Alberta will, however, continue to strenuously oppose any effort to ban exports to the U.S. or to tax our own people and businesses on goods leaving Canada for the United States. Such tactics would hurt Canadians far more than Americans.

We also continue Alberta’s call for the appointment of a border czar to coordinate the securing of our border against illegal migrants and drugs moving in both directions, and to achieve our nation’s 2% of GDP NATO commitment by 2027. These things should be done for the safety of all Canadians regardless of our trade dispute with the United States

Despite the disappointment of today’s decision there is also an incredible opportunity before us as a nation. Canada can and must now come together in an unprecedented effort to preserve the livelihoods and futures of our people and expand our political and trade relationships across the globe. We can no longer afford to be so heavily reliant on one primary customer. We must stop limiting our prosperity and inflicting economic wounds on ourselves.

Rather, we must unleash the true economic potential of our country, which possesses more wealth and natural resources than any other nation on earth.

[Stewart Adams @GrunkleStew2022]

@DoctorJack16 I'm a Western Canadian.
Benefits:
- Already closer ties to the US than Eastern Canada.
- Energy integration with a country that actually values it rather than shun it like Trudeau has.

Drawbacks:
- We love being Canadian.
- Poor US health care for have nots.
- US is a war bully.

[Cern Basher @CernBasher]

What is a Humanoid Robot?

Yes, it's a machine, but it's so much more than that.

It's a form of labor that we've never had before - one that can compete with human labor.

It's a next level computing device - it can do whatever a computer or smartphone can do, but it can also sense the real world and think for itself.

It's an environmental sensor. It could detect unhealthy toxins in the environment. Whether used in factories, laboratories, home or disaster zones, a bot can provide real-time analysis - massively improving safety.

It can communicate with anyone and everything - not only will it understand English, French, Spanish, etc., but also the languages of math, coding, chemistry, biology, music, etc.

It will the most patient tutor / coach / guide that anyone has ever seen! Ask it the same question a thousand times and it will patiently respond. The bot can adapt to a person’s learning pace and style, offering targeted lessons or training regimens.

It will be an assistant / caregiver that's available to you 24/7 - and it shows up to work every day!

And finally, it will be a vessel of intelligence that contains all of humanity's knowledge. Constant software updates and high speed connectivity means it will stay on the cutting edge of science, culture, and technology, offering insights drawn from humanity’s collective discoveries.