Günesdogan Lab

Developmental and Stem Cell Biology lab. Focussing on transcriptional control and primordial germ cells.

[Günesdogan Lab @guenesdoganlab]

📢Have you ever wondered how to differentiate primordial germ cells from marmoset iPSCs under defined conditions? Check out our latest paper 😀@LSAjournal: https://t.co/83Hc7aRFLb🧵👇(1/5)

[Günesdogan Lab @guenesdoganlab]

📢Today: Join us for the Ernst Caspari Lecture by Meritxell Huch @MeriHuchlab at 1:15pm @uniGoettingen!

[IMBA imbavienna.bsky.social @IMBA_Vienna]

The deadline to submit your abstract for a talk at the 2025 SY-Stem Symposium has been extended to January 22, 2025. Registration deadline remains on February 15th. For more details and to submit your abstract, visit: https://t.co/u5dkeTZ4Rm
We hope to see you there!
#SYStem2025

[Developmental Cell @Dev_Cell]

Online now: Initiation and maintenance of the pluripotent epiblast in pre-implantation human development is independent of NODAL signaling https://t.co/BLQEIceQDu

[Hansong Ma @Hansong_Ma]

Looking for a postdoc position? We are hiring!

https://t.co/VsQFORCEIO

Apply before the 4th Oct deadline!

[Günesdogan Lab @guenesdoganlab]

Check out this fantastic work by @ReikLab @C_D_Todd. Big thank you for this great collaboration!

[Reik Lab @ReikLab]

Preprint alert! 🎉 @C_D_Todd and the team used multi-omic profiling of human and mouse embryonic development to identify a conserved program of epigenetic priming at lineage specific enhancers for all three germ layers within the epiblast.

https://t.co/bSMkpnlfuE

[Epigenetics Podcast @epigenetics_pod]

In the most recent episode we spoke to @TeifLab from the University of Essex about his work on nucleosome positioning in #cancer #diagnostics. #podcast #epigenetics

Listen here: https://t.co/sSlXoNejpM

[Marta Shahbazi @Marta_Shahbazi]

📢📢New paper alert! The work of Aly, the first PhD student in my lab is out! We have explored the mechanisms of germline entry in the mouse and identified integrin signaling as a new roadblock of primordial germ cell specification. Keep reading: https://t.co/S8vKSZIbXG

[LifeScienceAlliance @LSAjournal]

Don't miss this article in our Special Collection on Stem Cells!
Generation of marmoset primordial germ cell–like cells under chemically defined conditions @guenesdoganlab @uniGoettingen @DPZ_eu
https://t.co/HdkI7KEzmf

[Bedzhov lab / Embryonic Self-Organization @emselor]

Just as sci-fi heroes enter stasis for space travel, embryos can pause their development in a state of dormancy. We present the single-cell atlas of embryo dormancy revealing its dynamics & the role of the microenvironment. Congrats to Rui Chen & the team! https://t.co/94mGsirrFr

[Gurdon Institute @GurdonInstitute]

🎉Three cheers for Prof Sir Tony Kouzarides who’s been awarded a knighthood for his services to healthcare innovation and delivery! Tony said: “I am delighted to receive this honour, which reinforces the importance of translating basic research into therapies by engaging academic researchers with healthcare businesses."

[Evgeny Kvon @evgenykvon]

How do enhancers work over distances that sometimes exceed megabases? Excited to share our work led by @gracecbower where we uncover a unique sequence signature globally associated with long-range enhancer-promoter interactions in developing limb buds: https://t.co/n0p7BdxSdq 1/

[Magdalena Zernicka-Goetz @ZernickaGoetz]

What is the origin of our body? Our paper @CellCellPress shows that when a human embryo is one day old and comprises just two cells, only one cell will create most of the fetus in addition to placenta, while the other cell will create placenta.
https://t.co/88l48YezzA

[Jamie Hackett @hackettlab]

How do chromatin modifications quantitatively impact gene expression?

How do sequence variants or combinatorial marks influence relationships?

We developed a modular #EpigenomeEditing toolkit to systematically test these Q, published today 🧵…

https://t.co/2p4W0J50Oc

[Jamie Hackett @hackettlab]

The gut microbiome influences metabolites, hormones and immune function

Perturbing gut microbiota therefore impacts homeostasis across somatic tissues

Could it also affect the reproductive system - and even offspring?

See our results👇& tweetorial🧵

https://t.co/lb6w6BjoW7

[Ramiro Alberio @AlberioRamiro]

📢we are recruiting postdocs to study #germcell biology and in vitro #gametogenesis together with @TomBurdon @roslininstitute and @IanAdamsLab. More details here: https://t.co/ghQ035Sw1H🐃🐂🐂.. @UoNBiosciences

[Günesdogan Lab @guenesdoganlab]

@mz_science Congratulations! Great news!!

[Vicki Metzis @metzisv]

Preprint alert! With Irene Amblard @CroBeaver @BorisLenhard @ImperialMed @MRC_LMS we dissect a regulatory circuit that operates during mouse caudal body dev to control Cdx2

Spoiler alert - a single motif switch converts a silencer into an enhancer: https://t.co/3FgZdHsQmu

[Tommaso Cavazza @CavazzaLab]

🚨 Job Alert for Postdoc!
We are looking for a passionate and motivated postdoc to join our team and work on the mechanism and functions of 🐄 embryo cell size regulation.

Check the image for more details on the position, the project, and how to apply. (1/2⬇️)

[Marta Shahbazi @Marta_Shahbazi]

Extremely happy to share the first manuscript of the lab! 🥳🥳🥳In this paper, we have looked at the coupling between delamination and differentiation at gastrulation. If you are interested in pluripotency, gastrulation, and mouse embryos keep reading! https://t.co/PIe2KmoiNn

[Günesdogan Lab @guenesdoganlab]

Great meeting to celebrate the discovery of genomic imprinting and to reunite with the alumni of Azim Surani's lab!

[Harry Leitch @HGLeitch]

40 years ago today!