HackAging.ai

News about technology, money, and decisions shaping how long people live

[HackAging.ai @HackAgingAI]

Vadim Gladyshev of @harvardmed told @ARDD_Meeting that compounds picked by matching longevity gene signatures lengthened old mice's lives five times in ten. Counted strictly it is four of nine plus an earlier hit, two worked only in males, and a second round is doing worse.

[HackAging.ai @HackAgingAI]

https://t.co/AbC3d9YCrj

[HackAging.ai @HackAgingAI]

Cells that stop dividing with age tend to swell, and a preprint in human retina cells suggests the swelling can itself keep them stopped: giant cells skipped part of the MDM4 message, loosening the leash on p53, which held them before copying their DNA.

[HackAging.ai @HackAgingAI]

https://t.co/kwAzjufa1s

[HackAging.ai @HackAgingAI]

The UK @cabinetofficeuk has launched an AI Biosecurity Lab to spot outbreaks and speed vaccines sooner: £100 million in public money plus up to £200 million in model credits from @OpenAI and @AnthropicAI. It names no first project yet, and no measure of success.

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https://t.co/Bg5wBUaQRW

[HackAging.ai @HackAgingAI]

The same blood test can read five years older on one aging clock and three years younger on another. @Skoltech researcher Dmitrii Kriukov explains why: each clock restates the inputs and target its maker chose, so only one checked in new people can guide anti-aging trials.

[HackAging.ai @HackAgingAI]

https://t.co/2zMnaAqQlG

[HackAging.ai @HackAgingAI]

To find why some mammals live many times longer than others, @MaxUnfried of @TTIScience proposes a shared freezer bank of tissue from about 200 species, young to old, all stored and measured the same way, so lab quirks stop passing for biology. For now it is a plan.

[HackAging.ai @HackAgingAI]

https://t.co/daxvVspAHh

[HackAging.ai @HackAgingAI]

Immortalist @andreypnfrv proposes that people in cryostasis keep a box of dated traces, boarding passes, notes and photos, to rebuild their life story if revival ever leaves memory gaps. Like a memory patient's notebook, it could restore the order of a life, not the memories.

[HackAging.ai @HackAgingAI]

https://t.co/x9TvUhZZXw

[HackAging.ai @HackAgingAI]

Two hours of darkness can push a plant's daily clock earlier, later or not at all, depending on the hour. A team including @umichkim used a neural network on old glow recordings to map that sensitivity hour by hour, then predict what longer nights would do.

[HackAging.ai @HackAgingAI]

https://t.co/goyLhJN7dt

[HackAging.ai @HackAgingAI]

An atlas of about 375,000 vessel-lining cells from 12 human tissues, published in @NatureAging, finds that with age inflammation genes rise in every tissue while each organ adds its own changes, and veins lose the most of the genes that grow new vessels.

[HackAging.ai @HackAgingAI]

https://t.co/1AmvY14cyU

[HackAging.ai @HackAgingAI]

Aging researcher Saul Newman, in an AMA opened by @mitpress for his book Morbid, says a supplement that truly slowed aging would show up in an ordinary trial: an eight-year rewind needs about 460 people per group. A small slowing would need millions, or real illness counted.

[HackAging.ai @HackAgingAI]

https://t.co/fEq8HqO1h4

[HackAging.ai @HackAgingAI]

Former OpenAI executive @kevinweil and co-founders raised $215 million for @warpsciences, a US lab that makes and tests drug molecules for other companies and records every step so AI can learn from real experiments. It owns no drug, and its speed is still unshown.

[HackAging.ai @HackAgingAI]

https://t.co/49TTD9jiHq