Harkness Group

Molecular Biophysics Group at the University of Guelph
We put curves through data points.
Biophysics | Biomolecular dynamics

[Harkness Group @harkness_group]

We are live! Accepting applications for undergraduate and graduate studies. https://t.co/1w6zDeMDgx

[Vahidi Lab@UofGuelph 🇨🇦 @VahidiLab]

1/🧵Human ClpP protease is targeted in cancer therapy with the activator ONC201 @chimerix Yet all structures of ClpP have captured it in its inactive state, even when bound to activators! ClpP is paradoxically activated by inhibitors at low concentrations before inhibition starts

[Cezar Khursigara @CMKhursigara]

Biochemistry - https://t.co/Eh6rFHp9mj

[Cezar Khursigara @CMKhursigara]

Immunology - https://t.co/RA85pfWxAC

[Cezar Khursigara @CMKhursigara]

Molecular and Cellular Biology at the University of Guelph is hiring THREE new tenure-track Assistant Professors!

Join our world-class, multidisciplinary environment where you’ll collaborate with excellent people and contribute to groundbreaking research and education.
⬇️. .

[Harkness Group @harkness_group]

1/4 Interested in hydrodynamics, cryo-EM, and proteins that form cages around cargo molecules? Check out our latest preprint https://t.co/UU5ZmNTV7l.

[Harkness Group @harkness_group]

4/4 The ability to form these cage ensembles may be relevant for capturing clients of very different sizes within the periplasm. @JustinDiTrani @LEK_Lab

[Y. Toyama @y_toyama_nmr]

Our new paper is out in PNAS. Here, we used an NMR method to measure de novo electrostatic potential developed by @IwaharaLab, and applied the method to the intrinsically disordered region of CAPRIN1, which phase separates upon the binding to ATP.
https://t.co/5oZArI9L27

[Kurt Buhler @kurtbuhler]

New post: How #PowerBI can bring value to academic research

https://t.co/LDh0LlUoqk

How a scientific research department could benefit from a Power BI solution with self-service analytics & reporting, and why this could be valuable for researchers & society.

[Magnetic Resonance News @nmr900]

At @ENC_Conf @Bruker introduces the new Heliosmart Recovery solution, a compact, easy-to-site system that can be retrofitted to collect helium gas boil-off from installed NMR magnets https://t.co/JvcRaZK0ZE #NMRnews #NMRchat #NMR #ENC2022

[Y. Toyama @y_toyama_nmr]

I am happy to announce that our new paper focusing on the dynamic interaction between human HtrA2 protease and a model protein substrate has been published!
Many thanks to @robharkness_ and @LEK_Lab.
https://t.co/WgGb1PBbEX

[Kay Lab @LEK_Lab]

Our lab has post-doctoral position(s) available in biomolecular NMR application and methods development!

Please RT.

[Ben Nashman @ben_nashman]

MRIs and NMR machines require incredibly uniform magnetic fields, not varying in strength by more than a fraction of a part-per-million (equivalent to looking at the thickness of a piece of paper from a mile away!)

How can you possibly build magnets that accomplish this??

[Y. Toyama @y_toyama_nmr]

The review focusing on the methyl-TROSY application to the allosteric interactions in oligomeric proteins has been published!
https://t.co/uDZVougWpH

[Y. Toyama @y_toyama_nmr]

Our new paper has just been published in https://t.co/MkjohYxOsY

If you are interested in protein folding and chemical exchange saturation transfer (CEST)!

[Harkness Group @harkness_group]

@y_toyama_nmr Really excellent work Yuki!

[Y. Toyama @y_toyama_nmr]

Our latest paper came out! If you are interested in inter-protomer allosteric communications in oligomeric proteins...
https://t.co/mVsQguof12