Vahidi Lab@UofGuelph 🇨🇦

Assistant Professor @uofg | Biochemist | Structural Biologist | Mass spectrometry | NMR spectroscopy

[Vahidi Lab@UofGuelph 🇨🇦 @VahidiLab]

1/🧵Human ClpP protease is targeted in cancer therapy with the activator ONC201 @chimerix Yet all structures of ClpP have captured it in its inactive state, even when bound to activators! ClpP is paradoxically activated by inhibitors at low concentrations before inhibition starts

[Irina Bezsonova @IrinaBezsonova]

Please share:
Hot off the press in NAR @OxfordJournals

We solve the structure of the elusive “pixel” domain within human PML protein that looks like a nuclease but is not.
Very proud of this collaboration with the Weller and Hao labs at UConnHealth.

https://t.co/RNKsjtgBn9

[Vahidi Lab@UofGuelph 🇨🇦 @VahidiLab]

Huge collaborative work with @OICR_news , @UHN_Research , and @NatalieZeytuni @McGill_ACB

[ShorterLab @ShorterLab]

Allosteric inhibition of human mitochondrial ClpP by hijacking the dordaviprone (ONC201) binding site: https://t.co/9HY9xRO1h1

[ShorterLab @ShorterLab]

Allosteric inhibition of human mitochondrial ClpP by hijacking the dordaviprone (ONC201) binding site: https://t.co/9HY9xRO1h1

[University of Toronto @UofT]

#UofT researcher Lewis Kay awarded 2026 Royal Medal by U.K.'s Royal Society 🏆 https://t.co/b6B5hmLECm

[MCB at UofG @UofG_MCB]

📢CONGRATULATIONS TO DR. MADISON TURNER on successfully defending her thesis on "Allosteric regulation of the Mycobacterium tuberculosis proteasome"👏👨‍🎓🥂🎉
🗓️August 20th
🔬Vahidi Lab

[MCB at UofG @UofG_MCB]

📢CONGRATULATIONS TO DR. BRADLEY DAVIS on successfully defending his thesis on the "Substrate engagement mechanism of the bacterial proteasome activator Bpa"! 🎉👏🥳
🗓️August 13th
🔬Vahidi Lab

[MCB at UofG @UofG_MCB]

📣CONGRATULATIONS TO DR. MONICA GONCALVES on successfully defending her thesis on "Mechanisms of allosteric regulation in human mitochondrial ClpP protease"!👏👏🍾🎉
🗓️August 25th
🔬Vahidi Lab

[The Hospital for Sick Children (SickKids) @SickKidsNews]

SickKids' Sr. Scientist Dr. Lewis Kay has received a prestigious 2026 Royal Medal from The Royal Society.

In a new Q&A, Dr. Kay opens up about his journey, priorities and legacy ⬇️

https://t.co/SsZO1fORNb

[MCB at UofG @UofG_MCB]

📣CONGRATULATIONS TO JACQUELYN OGATA-BEAN on successfully defending her thesis on "De novo design and characteri-589! of human mitochondrial ClpP activators"!👏👏🍾🎉
🗓️August 18th
🔬Vahidi Lab

[Rosenzweig Lab @lab_rosenzweig]

After a while not posting, happy to share our latest paper on how the different J-domains interact with the various HSP70s! Proud of Roni and of the outcome🏆 @PNASNews
https://t.co/zX63iqVlnF

[U of T News @UofTNews]

#UofT Professor Raquel Urtasun and John Rubinstein, senior scientist at @SickKidsNews and professor at @uoftmedicine, have been elected 2026 Fellows of the @royalsociety, the U.K.'s national academy of sciences https://t.co/TvER10KPFu

[Journal of Biological Chemistry @jbiolchem]

The ubiquitous biology of intracellular protein degradation: a tribute to Alfred L. (“Fred”) Goldberg. The review articles in this series highlight key areas shaped and inspired by his enduring contributions.
https://t.co/MSmwZbe0jt

[Magnetic Resonance News @nmr900]

Researchers at the University of Guelph & University of Toronto, led by Siavash Vahidi @VahidiLab and Lewis E. Kay @LEK_Lab together with Waters Corp, used NMR to identify a potential drug target in the tuberculosis stress-response system https://t.co/Ro438o5kqi #NMRchat #NMR 🧲

[MCB at UofG @UofG_MCB]

CONGRATULATIONS to our Phillips Scholarship Winners, Nicholas Gervais (Shapiro Lab) and Bradley Davis (Vahidi Lab)!!👏👏👏🎉🥳🎈

[Konermann Lab @KonermannLab]

Can enzymes retain catalytic activity in the gas phase? Using tandem MS, molecular dynamics simulations, and enzyme variants courtesy of the @VahidiLab, Kirsty (@kirstynyk) uncovers new insight towards this question.

Now published in JACS (@J_A_C_S)!

https://t.co/7GQLvBTEdy

[Carolina Tropini, PhD @CTropini]

CIHR funding rate: 13.6%.
Early 2000s: 30%+.

Canada’s new $1.7B Impact+ program recruits talent — but without increased Tri-Council base funding, we risk further strain on an already stretched system.

We’re calling for $1B over 5 years.
Support here: https://t.co/iknRwlOqvM

[Dougan Lab @DouganLab]

Molecular mechanisms of mitochondrial AAA+ proteases - Journal of Biological Chemistry https://t.co/tRmNOf5auw

[Biophysical Society @BiophysicalSoc]

Join 2026 BPS Lecturer Lewis Kay on Tuesday, February 24, 2:00 PM - 3:00 PM at #bps2026 for an informal discussion. Dr. Kay will share insights from his scientific career—from pioneering discoveries to lessons learned along the way—and reflect on how the field continues to evolve

[Cezar Khursigara @CMKhursigara]

MCB @ U of Guelph is hiring (again)! 🎉
Tenure-track Assistant Professor in Biochemistry
Part of our strategic cluster hire.

Apply now 👉 https://t.co/rj68ZBWlbs

#Biochemistry #FacultyJobs #AcademicTwitter #MolBio

[Irina Bezsonova @IrinaBezsonova]

Out in @pnas today
Showcasing the power of NMR!

NMR and enzyme kinetics show USP7 enzyme transiently sampling a low-populated active state, and its disease-causing variant enhancing these dynamics
https://t.co/g1SmP4nBox

Stellar work by students Gabi Valles and Emilie Korchak