Top Tweets for #ACTIV6
@CovidAnalysis @NIHDirector_Jay The way repurposed drugs were tested during pandemic was catastrophic, e.g. @NIH funded #activ6 trial that destroyed evidence of 5 drugs by including patients already healed at baseline in all treatment arms.
https://t.co/toCM8iHJpr
These RCTs designed to fail are not science.
@SabinehazanMD The miracle drug doesn't work if you are already healed.
You should tell #activ6 investigators... They gave IVM to people who already recovered after 13 days of illness.
And they wonder why the results are not very positive.
DB RCT lover @VPrasadMDMPH seems to love only RCTs in which some patients received the drug when they were already healed #activ6, not well conducted ones showing repurposed drugs are far more efficient than vaccines to prevent infections (NNT=2.6)
https://t.co/E736bzeuvc
🤔
⏰⏰⏰ @VPrasadMDMPH , @GidMK and the anti-IVM squad.
https://t.co/E736bzeuvc
How do you feel knowing you took part in the disinformation campaign about efficacy of IVM for covid prophylaxis leading to millions avoidable infections?
JE suis le premier au monde a avoir alerté sur le fait qu'il manquait plus de 15% des participants à l'essai clinique #Activ6 IVM 600 dans l'étude publiée dans @JAMANetwork :
https://t.co/PyS7gdTFhV
https://t.co/ihG5mG4Sgt
pendant que les PUPH partageaient sans rien voir.
2/n
This is a farce.🤬
In the @JAMANetwork, authors claim that 1334 participants were randomized and 1206 received the drug when enrollment was stopped.
On clinicaltrials, they claim that 1459 participants were randomized and 1432 received the drug !
Ok, more details. So, #Activ6 investigators have data not collected on 46 participants FOR THE PRIMARY OUTCOME of ivm 600 arm.😱
This didn't happen in the ivm 400 arm.
What is the time between symptom onset
and receipt of drug for those, we don't know.
1/2
Ok, it seems that it's "just" missing data:
Strangely, all these 46 participants are part of the 226 wrongly excluded from first analysis, because there was no missing data in the first publication.🤔
#activ6: still 46 patients lost in this diagramm...
https://t.co/J87jwlhp5H
They claim to have 708 and 724 at baseline.🤔
@ACTIV6study are your statisticians burned out?😱
While #Activ6 ivm trial authors fixed a mistake (they forgot to include >15% of participants in the analysis🤪 #GoldStandard), the revised version reveals more inconsistencies.😱
https://t.co/klezayBDAW
WTF these people in clinical research are doing with their data???🤔
While #Activ6 ivm trial authors fixed a mistake (they forgot to include >15% of participants in the analysis🤪 #GoldStandard), the revised version reveals more inconsistencies.😱
https://t.co/klezayBDAW
WTF these people in clinical research are doing with their data???🤔
#Activ6 trial, ivermectin 600 μg/kg arm. As I pointed in november 2023, the investigators had wrongly excluded 226 patients from analysis in the @JAMANetwork publication. This issue (the trial has many other issues) has finally been fixed.
https://t.co/QTZfDUoBKT
1/n
https://t.co/yhNg5uHcUj
While I continue to be insulted by academicians defending the pharmaceutical cartel, #Activ6 investigators addressed and fixed the first point: they forgot to include 15% of participants in the analysis.😱
Still waiting answers of 4 other points.
1/n
#Activ6 trial, ivermectin 600 μg/kg arm. As I pointed in november 2023, the investigators had wrongly excluded 226 patients from analysis in the @JAMANetwork publication. This issue (the trial has many other issues) has finally been fixed.
https://t.co/QTZfDUoBKT
1/n
Ivermectin: Time to recovery improvement in young people: look how the results are consistent in #activ6 trial (0.4mg and 0.6mg arms) HR=1.18, HR=1.2 and #principletrial HR=1.19
https://t.co/XNkdLrtFkn
https://t.co/Ck5N0Cj0Jz
https://t.co/uVYi7tWzLQ
Far better than paracetamol😀
I bet the issue comes from the fact #Activ6 investigators rushed the publication of results of their trial before publication of #prinicipletrial which had a slightly better protocol and positive result on primary outcome.
2/n
#Activ6 trial, ivermectin 600 μg/kg arm. As I pointed in november 2023, the investigators had wrongly excluded 226 patients from analysis in the @JAMANetwork publication. This issue (the trial has many other issues) has finally been fixed.
https://t.co/QTZfDUoBKT
1/n
This is a farce.🤬
In the @JAMANetwork, authors claim that 1334 participants were randomized and 1206 received the drug when enrollment was stopped.
On clinicaltrials, they claim that 1459 participants were randomized and 1432 received the drug !
That's what happens in the clinical trials that are qualified as the most serious by medical community.
In the #ACTIV6 trial arms testing ivermectin,
https://t.co/ViiK0t45Ge
https://t.co/J87jwlhp5H
resp. 6.85% and 5.72% of participants had no more symptom when treatment started.
Principle trial: https://t.co/Oti5RwGfCf
They tried to recrute late stage patients (like #Activ6 trial) to hide positive results, but, even if the treatment was delayed compared to molnupiravir/paxlovid RCTs, they kinda failed, and then tried to hide significant positive data.
On comprend les résultats négatifs des essais #activ6 sur l'ivermectine, la fluvoxamine, etc... dans lequel les patients étaient traité après un délai outrageusement long (certains étaient déjà guéri au moment où ils recevaient le médicament).
6/n
We still have no explanation about large discrepancies of data of #activ6 trial between results published on clinicaltrials website and results published in the @JAMANetwork 😱
#ScienceIsFake
This is a farce.🤬
In the @JAMANetwork, authors claim that 1334 participants were randomized and 1206 received the drug when enrollment was stopped.
On clinicaltrials, they claim that 1459 participants were randomized and 1432 received the drug !
@CKellyUAP Incompetent or corrupt?
The answer about #activ6 investigators is CORRUPT, because the answer was in the literature they referenced as rationale for dosage.
https://t.co/oG82cpTZQl
2/ They especially specify that drug should be taken on an empty stomach, knowing from Krolewiecki et al. that this is the key factor that lead to low levels of mean IVM plasma concentration, thus the less chance of seeing an antiviral effect.
10/n
The anti-IVM squad who was not able to spot a single bias in Together trial, #Activ6 trial and Lopez-Medina et al., 😱is working on "the development of a tool to
identify problematic randomised controlled trials in
systematic reviews".🤡
https://t.co/EIxMJMdQ84
@alexandrosM
Congrats to the @ncats_nih_gov #N3C team for receiving the @HHSGov Secretary's Award for Distinguished Service and to Sarah E. Dunsmore for her HHS Secretary’s Commendation for her leadership of the #ACTIV6 clinical trials! Learn more: https://t.co/K1feiWRceM #CTSAProgram
#Ivermectin #Activ6: participant flow https://t.co/pKqTyCrkqw vs JAMA publication
Ivermectin 400 ✅
https://t.co/RPXyDRxXzt
https://t.co/ViiK0t45Ge
1/3⤵️
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