Top Tweets for #APHINITY
🚨 #APHINITY Trial • #ESMOBreast25🚨Perjeta+ Herceptin + chemo significantly improves long-term survival for people with HER2-positive early-stage #breastcancer, especially those with lymph node involvement or hormone receptor–positive tumors. 🔗 https://t.co/YrnU7QyuFw #BCSM
#ESMOBreast25 Updates!
Final OS analysis of #APHINITY (11.3y)
Significant reduction in risk of death (-21%; HR 0.79) in N+ HER2+ eBC for addition of pertuzumab to trastuzumab/chemo
10y OS of 89.6% vs 86.9% (Δ=2.7%) in N+ HER2+ BC
@OncoAlert #bcsm
Agree with this for TNBC and HER-2 at least. #APHINITY data - took us over 11 YEARS to see the OS benefit of adj pertuzumab.
Luckily it was already approved, how many pts would have missed out on cure waiting 11 years for OS to catch up?
#ESMOBreast25
#ESMOAmbassador
@myESMO
What u think about this @oncology_bg @5_utr @dr_yakupergun @stolaney1 @myESMO @Timothee_MD #ESMOBreast25 @OncoAlert
💫Sub-analysis of #APHINITY shows overweight/obesity (BMI≥25) at diagnosis linked to worse iDFS (aHR 1.27), DRFI (1.32), OS (1.38), 🆚normal weight.
Weight change at 2 yrs had no impact.
🔗https://t.co/6PVtZyaP63
@OncoAlert @matteolambe @ElisaAgostinett @E_de_Azambuja
#APHINITY final OS at 11.3y: In N+ HER2+ eBC, adding pertuzumab to trastuzumab/chemo reduced death risk by 21% (HR 0.79), with 10y OS of 89.6% vs 86.9% (Δ=2.7%)
IDFS also improved (HR 0.79), with 10y IDFS of 87.2% vs 83.8% (Δ=3.4%)
@myESMO
#ESMOBreast25
No benefit of adjuvant Trastuzumab and Pertuzumab in Node negative disease in the #Aphinity #IAmAPractisingOncologist
Final, 11-year OS analysis of #APHINITY, showing a significant benefit in OS with adjuvant pertuzumab, fully driven by the N+ group. Benefit irrespective of hormone receptor status. No reduction in CNS recurrences. #ESMOBreast25 #ESMOAmbassadors
Proffered paper session at #ESMOBreast25 with final results from #APHINITY trial at 11.3 years median follow-up addressing the addition of adjuvant #pertuzumab to #trastuzumab plus #chemotherapy in patients with #HER2+
@myESMO #ESMOAmbassadors @OncoAlert #bcsm @E_de_Azambuja
Final, 11-year OS analysis of #APHINITY, showing a significant benefit in OS with adjuvant pertuzumab, fully driven by the N+ group. Benefit irrespective of hormone receptor status. No reduction in CNS recurrences. #ESMOBreast25 #ESMOAmbassadors
#SABCS23 Highlights w/ @StoverLab on HER2+ #breastcancer
- #APHINITY
- #KATHERINE
- #HER2Climb02
Full discussion:
- https://t.co/geINkCn6cO
- https://t.co/ngOz4BeM83
- Also on the “Oncology Brothers” podcast
#MedTwitter #OncTwitter #bcsm @SABCSSanAntonio @TargetedOnc
Does the benefit of trastuzumab and pertuzumab change according to HER2 and ER expression⁉️
At #SABCS23 I discussed with @Medi_Mix the results of our sub-analysis of the #APHINITY trial
@JulesBordet @BIGagainstBC @OncoAlert
⬇️⬇️⬇️
Explore the APHINITY trial's new horizons with Dr @ElisaAgostinett at #SABCS2023. Discover the nuanced benefits of pertuzumab in early HER2+ breast cancer treatment. 👀 https://t.co/yCP1Rcta4n
#Oncology #BreastCancerResearch #MediMix
And now it’s time for @ElisaAgostinett from @JulesBordet on the #SABCS23 stage presenting interesting data from the #APHINITY trial on #pertuzumab benefit according to ER and HER2 expression 👏🤩🇮🇹🔝
@BIGagainstBC @SABCSSanAntonio @OncoAlert
@ElisaAgostinett presenting on the analysis of ER and HER2 expression in #aphinity @JulesBordet @BIGagainstBC @ULBRecherche @OncoAlert
The #OncoAlertTopTweet #SABCS23 DAY1⃣
Tweet @OncoAlert 🚨 Faculty @ElisaAgostinett
Join us TODAY Wednesday for the Poster Spotlight Discussion on HER2+ #breastcancer!
Discussing intriguing results from the #APHINITY trial 📍Room Stars at night ballroom 1-2 at 5,30 pm
Best, @weoncologists
Join us tomorrow at #SABCS23 at the Poster Spotlight Discussion on HER2+ #breastcancer!
We will discuss intriguing results from the #APHINITY trial
📍Room Stars at night ballroom 1-2 at 5,30 pm CT time🇺🇸
@OncoAlert
Join us tomorrow at #SABCS23 at the Poster Spotlight Discussion on HER2+ #breastcancer!
We will discuss intriguing results from the #APHINITY trial
📍Room Stars at night ballroom 1-2 at 5,30 pm CT time🇺🇸
@OncoAlert
Just out in @ESMO_Open the cardiac❤️🩹 safety analysis of #APHINITY:
➡️Dual HER2-blockade with #pertuzumab and #trastuzumab does not⬆️the risk of cardiac events in patients with #breastcancer after >6 years of follow-up❤️👇🏻
@E_de_Azambuja @OncoAlert
https://t.co/822jRv4VSV
Just out our safety cardiac analysis on #pertuzumab and #trastuzumab in patients with #breastcancer in the #Aphinity trial @ESMO_Open @ElisaAgostinett @matteolambe @noam_ponde @Carmela_surgery @sdent_duke @JulesBordet @BIGagainstBC @escardio @ICOSociety
https://t.co/3PjGYyuxss
#Pertuzumab #APHINITY #ScienceLink
Ca. de mama temprano HER2+: Pertuzumab reduce riesgo de recurrencia de la enfermedad, estudio APHINITY
https://t.co/5H3N6YCxiq
Great discussion of #APHINITY OS update by @JavierCortesMD! Shoutout to @stolaney1’s APT/ATEMPT practice-changing de-escalation trials & to @prat_aleix’s HER2DX assay. The future of HER2+ breast cancer will be increasingly tailored to patient’s and tumor’s characteristics.
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