Top Tweets for #ASH2026
๐ง๐๐ฟ๐ป๐ถ๐ป๐ด ๐ฃ๐ฎ๐ด๐ฒ๐ ๐ง๐๐ฒ๐๐ฑ๐ฎ๐ | #ASH2026 edition
๐ญ๐ฌ ๐บ๐๐ฒ๐น๐ผ๐บ๐ฎ ๐ฎ๐ฏ๐๐๐ฟ๐ฎ๐ฐ๐๐ ๐โ๐บ ๐๐ฎ๐๐ฐ๐ต๐ถ๐ป๐ด ๐ณ๐ฟ๐ผ๐บ ๐๐ป๐ฑ๐ถ๐ฎ
With teclistamab (Tec), elranatamab (Elra), talquetamab (Tal) and SC Dara in our toolkit, my questions are about sequencing, duration, safety and access.
๐ญ. ๐ ๐ผ๐ป๐๐บ๐ฒ๐ป๐ง๐๐-๐ฒ | #426
At 13.4 monthsโ median follow-up, Tec+Tal vs EPd/PVd: PFS HR 0.11; Tal+Pom also improved PFS/OS. ~80% were anti-CD38-refractory. Watch the planned 26-cycle bispecific cap and immunoglobulin replacement burden.
๐ฎ. ๐ ๐ฎ๐ด๐ป๐ฒ๐๐ถ๐๐ ๐ -๐ฑ | #424
Elra vs DPd: PFS HR 0.56. Only 5.9% had prior anti-CD38 exposure: important when interpreting this for Dara-refractory relapse.
๐ฏ. ๐ช๐ต๐ถ๐ฐ๐ต ๐ฏ๐ถ๐๐ฝ๐ฒ๐ฐ๐ถ๐ณ๐ถ๐ฐ ๐ป๐ฒ๐
๐? | #2205
In a retrospective 187-patient series, 136 target-switchers had median PFS ~4 months with the second bispecific. Activity remains possible; the best order is unresolved.
๐ฐ. ๐๐ฎ๐ป ๐๐ฒ ๐๐๐ผ๐ฝ ๐ฏ๐ถ๐๐ฝ๐ฒ๐ฐ๐ถ๐ณ๐ถ๐ฐ๐? | #845
43 selected responders stopped; 12-month treatment-free PFS was 85.4%. Relevant to financial and infectious toxicity; selection bias limits conclusions.
๐ฑ. ๐๐ป๐ณ๐ฒ๐ฐ๐๐ถ๐ผ๐ป ๐ฝ๐ฟ๐ฒ๐๐ฒ๐ป๐๐ถ๐ผ๐ป | #2275
Modelled 1-year grade โฅ3 infection risk: 21.0% with continuous vs 38.3% with observed immunoglobulin replacement. Supportive care belongs in the budget; replacement was not randomized.
๐ฒ. ๐ช๐ต๐ผ ๐๐ต๐ผ๐๐น๐ฑ ๐ฟ๐ฒ๐ฐ๐ฒ๐ถ๐๐ฒ ๐ง๐ฎ๐น? | #934
Among 43 IHC-evaluable Tal patients, none of 19 with low/negative GPRC5D responded. Could pretreatment IHC improve selection? Retrospective data need validation.
๐ณ. ๐ฃ๐๐ฅ๐ฆ๐๐จ๐ฆ | #111
After ASCT, 236 patients stopped Dara per protocol; lenalidomide continued. Eligibility required โฅ24 months maintenance, โฅCR and โฅ12 months sustained MRD negativity by serial NGS.
๐ด. ๐๐ค๐จ๐๐๐ | #112
In high-risk smoldering MM, 7-year OS: 87.8% vs 78.7% with 3 years of SC Dara vs monitoring. Risk definitions and reliable follow-up are central before treating asymptomatic patients.
๐ต. ๐๐ฒ๐น๐ฎ๐ป๐๐ฎ๐บ๐ฎ๐ฏ ๐ฒ๐๐ฒ ๐บ๐ผ๐ป๐ถ๐๐ผ๐ฟ๐ถ๐ป๐ด | #419
A 30-patient BelaRd study in newly diagnosed MM tests symptom-guided dosing. Both groups still had eye examinations. A practical implementation question for belantamab.
๐ญ๐ฌ. ๐๐ซ๐๐๐๐๐๐๐ฅ-๐ฅ๐ฅ๐ ๐ : ๐ถ๐ฏ๐ฒ๐ฟ๐ฑ๐ผ๐บ๐ถ๐ฑ๐ฒ | #114
IberDd vs DVd: 10โปโต flow MRD-negative CR, 41.1% vs 20.7%. PFS results await presentation. A CELMoD future-access watch: 84.3% grade 3/4 neutropenia; anti-CD38-refractory patients excluded.
For MRD, 10โปโต is not 10โปโถ; matching sensitivity also does not automatically make flow and NGS interchangeable for a trialโs treatment decisions.
These are abstracts to examine closely, with fuller data still to come.
#TurningPagesTuesday #MMsm

๐ฉธ Join HemeHub this December for our Post ASH 2026 live webinar series!
Explore the latest updates in Leukemia, Lymphoma, Classical Hematology, and Myeloma through expert-led sessions.
๐ Register: https://t.co/TJfE4YDEpq
#HemeHub #ASH2026 #ASH26 #Hematology #HematologyOncology #HemeOnc #Myeloma #Leukemia #Lymphoma
๐ฉธ Schedule Update for HemeHubโs Post-ASH 2026 Live Webinar Series!
Our Myeloma session will now take place on December 23, while the Leukemia, Lymphoma, and Classical Hematology sessions remain scheduled for December 21.
๐ Register: https://t.co/TJfE4YDEpq
#HemeHub #ASH2026 #PostASH2026 #Hematology #HematologyOncology #Myeloma #Leukemia #Lymphoma
๐ฉธ #ASH26 | #AML Abstracts to Watch (Oral)
My current list of 11 AML abstracts to watch at #ASH2026 ๐ #leusm
A mix of potentially practice-changing frontline trials, menin inhibitors, MRD, and novel approaches in both younger and older patients.
1๏ธโฃ Ivosidenib + intensive chemotherapy in newly diagnosed IDH1-mutated AML
HOVON150/AMLSG29-18, phase 3
Superior event-free survival
๐ Abstract 0001, Press Program
๐
Sun Dec 13 | 7:00 AM CT
โ ๏ธ Oral/plenary slot not yet confirmed
๐ https://t.co/HAiAem9IzK
2๏ธโฃ Gilteritinib vs midostaurin in newly diagnosed FLT3-mutated AML
Subgroup analysis from HOVON156/AMLSG28-18/pasha
๐ Abstract 56 | Session 615
๐
Sat Dec 12 | 9:30 AM
๐ Great Hall BC
๐ https://t.co/vnNwomzMZ7
3๏ธโฃ Bleximenib in R/R AML with KMT2A rearrangements or NPM1 mutations
Topline results from phase 2 CAMELOT-1
๐ Abstract 661 | Session 616
๐
Sun Dec 13 | 4:30 PM
๐ Hall B
๐ https://t.co/Das1necevM
4๏ธโฃ Cladribine + LDAC + venetoclax vs intensive chemotherapy (7+3)
Patients โฅ60 years with newly diagnosed AML
๐ Abstract 57 | Session 615
๐
Sat Dec 12 | 9:30 AM
๐ Great Hall BC
๐ https://t.co/vuvS9OfmdF
5๏ธโฃ Can we stop HMA + venetoclax?
Discontinuation of hypomethylating agent + venetoclax in newly diagnosed AML with undetectable MRD
๐ Abstract 1009 | Session 617
๐
Mon Dec 14 | 4:30 PM
๐ Great Hall AD
๐ https://t.co/MiP4Z7F5BL
6๏ธโฃ Sonrotoclax + azacitidine across ELN 2024 genetic risk groups
Treatment-naive AML unfit for intensive chemotherapy
๐ Abstract 60 | Session 615
๐
Sat Dec 12 | 9:30 AM
๐ Great Hall BC
๐ https://t.co/gU3WGMcyAm
7๏ธโฃ Venetoclax + 3-day multi-frequency decitabine vs AZA + VEN
Older adults with newly diagnosed AML, updated randomized results
๐ Abstract 1012 | Session 617
๐
Mon Dec 14 | 4:30 PM
๐ Great Hall AD
๐ https://t.co/L7cHhkZ4IF
8๏ธโฃ Whole-genome-informed AML MRD testing
Prospective multicenter validation, MEASURE
๐ Abstract 390 | Session 619
๐
Sat Dec 12 | 4:00 PM
๐ Great Hall AD
๐ https://t.co/XPb38cdFAW
9๏ธโฃ VEN + AZA vs daunorubicin + cytarabine induction
Young adults with ELN adverse-risk AML, phase 2b
๐ Abstract 1010 | Session 617
๐
Mon Dec 14 | 4:30 PM
๐ Great Hall AD
๐ https://t.co/T8URfhrzzg
๐ Ziftomenib + gilteritinib in R/R NPM1- and FLT3-co-mutated AML
First results from phase 1 KOMET-008
๐ Abstract 66 | Session 617
๐
Sat Dec 12 | 9:30 AM
๐ Great Hall AD
๐ https://t.co/nTnyI2myj8
11/12
1๏ธโฃ1๏ธโฃ FLAI-G frontline in younger FLT3-mutated AML
Fludarabine + high-dose cytarabine + idarubicin + gilteritinib
First interim analysis, phase 2 GIMEMA AML2924
๐ Abstract 903 | Session 617
๐
Mon Dec 14 | 2:45 PM
๐ Great Hall BC
๐ https://t.co/OwFJZBjAnr
Lots to watch at #ASH26 in AML.
Particularly interested in the randomized frontline data, evolving role of menin inhibition, MRD-guided treatment decisions, and whether lower-intensity approaches can continue challenging conventional intensive chemotherapy.
Which AML abstracts are on your must-see list?
#AML #Leukemia #ASH26
#ASH2026: Pullarkat et al report real-world outcomes with duvelisib in a real-world cohort of 328 patients with nodal PTCL:
- ORR 46%, CRR 32%
- In TFH lymphoma: ORR 58%, CRR 46%
- Median duration of response 250 days
- 16% proceeded to alloSCT
https://t.co/UHtl0KGBoX
#ASH2026: Eche-Ugwu et al & the PETAL consortium report the first study to report HRQL outcomes in patients with PTCL. Rates of pre-treatment HRQL similar to other lymphoma subtypes. Congratulations to the authors for working to address this important gap.
https://t.co/ABFDRgupEA
#ASH2026 iMMagine-1 update: Anito-cel in RRMM (n=117, median follow-up 18 mo). ORR 96%, CR/sCR 75%, MRDโ (10โปโถ) 76% of evaluable pts, 24-mo PFS 58%, OS 84%, ICANS 8%, No delayed/non-ICANS neurotoxicity reported
#ASH2026 NMDP/CIBMTR present:
OPTIMIZE: โฌ๏ธ dose PTCy delivered 88.7% 1-yr survival in mismatched unrelated donor transplants
MEASURE: Genome-informed AML MRD testing achieved 97% sensitivity v. 31% standard care
CIBMTR: MCW-NMDP research collab. https://t.co/qSPPFnyd3k

Fellow #myeloma patients!
I'll be attending #ASH2026 with the @IMFmyeloma Patients at ASH team! โค๏ธ
Follow me for the latest research updates, key takeaways, and the patient perspective.
Have questions you'd like me to explore? Let me know!
#IMFASH26

๐ฉธ Mark your calendars for HemeHubโs Post-ASH 2026 live webinar series this December!
Join us for expert-led updates in Leukemia, Lymphoma, Classical Hematology, and Myeloma.
๐ Register: https://t.co/TJfE4YEceY
#HemeHub #ASH2026 #ASH26 #Hematology #HematologyOncology #HemeOnc #Myeloma #Leukemia #Lymphoma
๐ฉธ Schedule Update for HemeHubโs Post-ASH 2026 Live Webinar Series!
Our Myeloma session will now take place on December 23, while the Leukemia, Lymphoma, and Classical Hematology sessions remain scheduled for December 21.
๐ Register: https://t.co/TJfE4YDEpq
#HemeHub #ASH2026 #PostASH2026 #Hematology #HematologyOncology #Myeloma #Leukemia #Lymphoma
๐ข Exciting News - Abstracts for #ASH2026 are posted!!!
We are proud to be presenting our research this year investigating our mass spectrometry (MS) based assay for the quantification of soluble B-cell maturation antigen (sBCMA) in multiple myeloma (MM) serum samples.
๐ก The study found that our MS-based assay had good correlation to sBCMA ELISA in MM patients, demonstrating the potential to monitor disease burden in MM patients, regardless of their M-protein type.
In addition, we collaborated on a study with Washington University School of Medicine in St. Louis, to describe post-chimeric antigen receptor (CAR) T cell M-protein kinetics, using clonotypic mass spectrometry (CT-MS).
๐กย Findings demonstrate that CT-MS is highly sensitive for relapse, with detectable and increasing M-protein in 100% of relapse samples. Achieving undetectable CT-MS was highly dependent on M-protein half-life.
Read the full abstracts here:
4067: Mass Spectrometry Assay to Quantify B-Cell Maturation Antigen in Serum of Patients with Multiple Myeloma: https://t.co/zuok9rRida
4071: M-Protein Kinetics via Clonotypic Mass Spectrometry Following BCMA-Directed CAR T Cell Therapy: https://t.co/0Kpb6dbijn
#MultipleMyeloma #MM #MRD #MinimalResidualDisease #MMSM #CART #BCMA #MassSpec

@mghpetal has 5 abstracts accepted to the 2026 @ASH_hematology Annual Meeting!
๐ธ Read more: https://t.co/Qn3azNF4vm
#ASH2026
At ASH, drugmakers to showcase early data for three-pronged cancer therapies https://t.co/Z2t74F90x7 @ByJonGardner #ASH2026 $ABBV $JNJ
Nurix will report new and updated efficacy and safety data from the ongoing Phase 1a/1b study evaluating our investigational oral BTK degrader, bexobrutideg, in patients with relapsed/refractory CLL/SLL in a poster session at #ASH2026.
More details here: https://t.co/koJdGNMnDR

Our #ASH2026 abstract is now online
How does limited access to molecular testing affect AML risk stratification and outcomes?
We explored this question using 10 years of real-world data from Colombia.
๐จ๐ด Abstract #4579
https://t.co/tgXAl2juYJ
@VerismoTx to Present P-I (CELESTIAL-301) Data of SynKIR-310 for R/R B-Cell Non-Hodgkin Lymphoma at ASH 2026.
#VerismoTherapeutics #SynKIR310 #ASH2026 #Phase1Trial #Pharmashots #CellTherapy #Oncology #Hematology
https://t.co/8BoXkusq4T
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