Top Tweets for #ActivityMetabolomics
Discovery of a family of bile acid-methylcysteamines @Nature @Cornell @group_Schroeder #activitymetabolomics
A nuanced interplay between host and microbiota in regulating bile acid signaling pathways through FXR with a new target for metabolic disorders https://t.co/VvnLBbGJ9A
Sexual communication signals identified by @AndiFischer10 using untargeted #ActivityMetabolomics @SciReports https://t.co/kflmnC4Jcn https://t.co/g1FPWRn3Kc #XCMS @AndiFischer10 narrows down the active pheromones in spiders. Nice work Andi!
Hydroxyproline in fibrotic tumors may contribute to immune suppression. #Activitymetabolomics w @SHSpangenberg & @Amelia_Palermo @CellChemBiol show hydroxyproline enhances IFN-g-induced PD-L1 expression in cancer & immune cells, and inhibits autophagy https://t.co/j9o3qFQiJj
"a map of intestinal metabolism" helping to "identify metabolite–microbe associations, which provide a basis to connect the spatial occurrence of bioactive compounds" using longitudinal #activitymetabolomics @NatMetabolism @ETH_en Nice work Uwe Sauer team https://t.co/fe6s5tfbB6
Active vs Inactive metabolites @Metabolon with a focus on #ActivityMetabolomics although I would have expanded this concept beyond drugs and to endogenous metabolites @MartinGiera @JuliJivanisevic @mrins01
https://t.co/kflmnC4Jcn
https://t.co/iEdbtkUiEF
Drug-Initiated #ActivityMetabolomics (DIAM) at its best @Nature
https://t.co/UItkbEo7tW
https://t.co/hGsFYqwi5w
https://t.co/TpneDFzKll
Microbe derived metabolite identified as a means to improve chemotherapy efficacy
Bioactive metabolites, a favorite topic, and this time a new screening approach for the lipid variety by @RobPlumb @WatersCorp https://t.co/HhiPGvlyCc
Nice work Rob! @JProteomeRes #activitymetabolomics #activitylipidomics
A refreshing metabolite-based approach to cancer therapy #Matterhorn https://t.co/dtCZByFX6X
https://t.co/bMdu6wNXuJ
This could fall into the category of “allosteric regulation of receptors”
in the ID of bioactive metabolites using #activitymetabolomics
https://t.co/5pXnzYIDMu
Drug-Initiated #ActivityMetabolomics (DIAM) for brown fat conversion. These biological projects take forever but the end result (myristoylglycine) was worth it. Excellent work by Carlos Guijas! https://t.co/OY8jlJncIa
Researchers led by @kadzuis & Calibr have uncovered a metabolite that converts white fat (“bad” fat) to brown fat (“good” fat) cells. The finding offers a potential way of addressing metabolic conditions like obesity & type 2 diabetes https://t.co/JLeWZsLPPw @MetabolitesMDPI
FDA approves the use of endogenous metabolites for ALS disease. #ActivityMetabolomics at its most clinical. Thank you @CaymanChemical and @AvantiLipids for helping to populate #METLIN for such research. https://t.co/MKWbQh4LPf.
Another endogenous human metabolite used as a drug, bile acid tauroursodeoxycholic acid combined with phenylbutyrate has recently been approved for ALS in Canada. Both available as supplements #ActivityMetabolomics drug discovery https://t.co/5pXnzYIDMu https://t.co/znphJHUF2x
Carlos Guijas's Drug-Initiated #ActivityMetabolomics (DIAM) cleverly used stable isotopes to decipher the origins of myristoylglycine in #BAT generation. Combining a variety of technologies to identify an active endogenous metabolite, nicely done Carlos! https://t.co/hGsFYqeGGW
Drug-Initiated Activity Metabolomics (DIAM) identifies human endogenous metabolite myristoylglycine as a promoter of brown adipose tissue (BAT). Identifying active metabolites #activitymetabolomics using known drugs. Carlos Guijas absolutely beautiful work
https://t.co/70VhY7RNI2
Drug-Initiated #ActivityMetabolomics (DIAM) paper offers a #Pharma roadmap to
1. Discover synergistic endogenous metabolite - drug interactions
2. Improve safety/toxicity (e.g., endogenous CoQ10 inhibited by statin)
3. Potential to improve efficacy
https://t.co/70VhY7RNI2
Drug-Initiated Activity Metabolomics (DIAM) identifies human endogenous metabolite myristoylglycine as a promoter of brown adipose tissue (BAT). Identifying active metabolites #activitymetabolomics using known drugs. Carlos Guijas absolutely beautiful work
https://t.co/70VhY7RNI2
Drug-Initiated Activity Metabolomics (DIAM) identifies human endogenous metabolite myristoylglycine as a promoter of brown adipose tissue (BAT). Identifying active metabolites #activitymetabolomics using known drugs. Carlos Guijas absolutely beautiful work
https://t.co/70VhY7RNI2
Microbial metabolite & immunosuppression. Indole propionic acid’s negative immune-modulation effect of interest for modulation of cytotoxic T lymphocytes response in autoimmune diseases, type I diabetes or COVID. #activitymetabolomics with the microbiome
https://t.co/Nll18lpZHi
Untargeted isotope-based metabolomics & proteomics, followed by administration of lysine to human patients and healthy volunteers @NatureComms https://t.co/hlgASFZOYP. Spear-headed by @mrins01
@staruschenko & a large cohort of collaborators. A model #ActivityMetabolomics study
IPA microbial metabolite is certainly the most important molecule out of our lab @PNASNews
https://t.co/ypGsPV32CM with hundreds of subsequent studies, our latest #activitymetabolomics showing (unsurprisingly for a microbe) IPA induces immunosuppression https://t.co/Nll18lpZHi
Microbial metabolite IPA continues to show interesting activity @Nature today https://t.co/Lkup3td37G, this time in nerve #regeneration.
#activitymetabolomics showing up again from @PNASNews finding https://t.co/YqfJeXSMyv
@Robert_S_Jansen @ben_warth Interesting how responsive the companies are to good science @longlabstanford. All around a good week #activitymetabolomics
#activitymetabolomics at its best. Did anyone start synthesizing yet?
Exercise #activitymetabolomics in plasma reveals an endogenous metabolite that suppresses feeding https://t.co/3MFNokrDFP
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