Top Tweets for #ArterialCalcification
Metabolo-Epigenetic coupling #SmoothMuscleCell #ArterialCalcification
NR4A3 (⏫in calcified👤🐭aortas ) as a direct transcriptional activator of Glycolysis (target genes ALDOA PFKL) & indirect activator of calcific program
🤓Lactate production▶️Histone Lactylation H3K18la of PHOSPHO1 gene promoter, perhaps Wnt5a Wnt7b as well
🐭aortic & SMC calcification⏫by Exogenous lactate, ⏬by NR4A3 KO FX-11 (inhibitor of LDHA)
CUT&RUN NR4A3 + RNAseq NR4A3 KO➡️
297 genes controlled by NR4A3-mediated histone lactylation🤠
@CircRes 2024
https://t.co/3iGA2DfyCb
mTOR #ArterialCalcification
#Rapamycin almost Doubles lifespan 🤠 (T50 35->61 days) of Mgp KO🐭
An ectopic arterial calcification model with premature death
🤓WITHOUT impacting Aortic
1⃣Calcification: CT shows unaltered calcific volume but a ~10% down aortic mineral density)
2⃣Medial elastin
3⃣Osteogenic vs Contractile phenotype (Runx2 Acta2 Myh11)
4⃣Autophagy (LC3)
Inactivation of mTORC1 (Raptor KO) or mTORC2 (Rictor KO) in SMC does NOT prolong Mpg KO🐭lifespan
Very interesting & important findings even SMC-independent!😄
👉Does rapa modify causes of death?
👉How is mTOR signaling (pS6K1 or p4EBP1) inhibited in aortic SMC/endothelium or other tissues by rapa?
👉How rapa impact arteries/arterioles in other Mgp KO organs?
@StHilaireLab bioRxiv 2024
https://t.co/uCDB9wX6G5
📣 Our latest publication on incidental finding of arterial calcification on #mammography and risk of cardiovascular diseases in women is available on Clinical Imaging journal @CI_Journal @jpenamd
#arterialcalcification #womenhealth #calcification @WCMPopHealthSci
NIH News Week of April 1st: https://t.co/Tul37d424o
#cancer #CancerTreatment #ColorectalTumors #skin #SkinBiopsy
#ParkinsonsDisease #GeneticDisease #ArterialCalcification #sleep #teenagers
#SleepStudies #ScienceNews #research #ScienceAdvancements #NIH
#SmoothMuscleCell MMP3 mediates #ArterialCalcification in mice+Vitamin D3 (How?🧐)
MMP3 is the only MMP upregulated in calcifying rat aortic SMCs (Pi/Ca2+)
Raul Guzman lab #CardiovascRes 2024
https://t.co/0WAQoyfty9
In loving memory of Adam, whose brief but precious life continues to inspire and touch the hearts of those who love and remember him.
#gaci #InfantLoss #ArterialCalcification
#PalmiticAcid suppresses Sirt6 to promote #SmoothMuscleCell Apoptosis+#Calcification
An important signaling pathway for #HighFatDiet-induced #ArterialCalcification
Dr. Biao Ding & Xiang Li labs J Hypertens 2023
https://t.co/0H2UfBjRkj
Remember to wear your red and white tomorrow! Tag us @gaciglobal and use the hashtag #gaciarhr2awarenessday!
#enpp1deficiency #abcc6deficiency #gaci #arhr2 #raredisease #circulatinghope #arterialcalcification #rickets
Prenatal treatment may be an option to help minimize the progression of GACI.
#enpp1deficiency #abcc6deficiency #gaci #arhr2 #raredisease #circulatinghope #arterialcalcification #rickets
This can pose serious risks to infants with GACI as it increases their risk of high blood pressure, stroke, and heart attack.
#enpp1deficiency #abcc6deficiency #gaci #arhr2 #raredisease #circulatinghope #arterialcalcification #rickets
Clinical trials for enzyme replacement therapy are ongoing in adults diagnosed with ENPP1 Deficiency and ABCC6 Deficiency. We are hopeful that there will be pediatric trials in the future.
#enpp1deficiency #abcc6deficiency #gaci #arhr2 #circulatinghope #arterialcalcification
To connect with a family who has experienced prenatal treatment for GACI or if medical contacts are needed, please email GACI Global at [email protected].
#enpp1deficiency #abcc6deficiency #gaci #raredisease #circulatinghope #arterialcalcification
If you have previously had a child diagnosed with GACI, prenatal genetic testing via CVS or amniocentesis can be beneficial in terms of developing an appropriate treatment plan.
#enpp1deficiency #abcc6deficiency #gaci #raredisease #circulatinghope #arterialcalcification
It is important to know the signs of respiratory distress in an infant with GACI so that you can get them proper treatment as soon as possible.
#enpp1deficiency #abcc6deficiency #gaci #arhr2 #raredisease #circulatinghope #arterialcalcification #rickets #respiratorydistress
Calcification can occur in arteries throughout the body. Ultrasound imaging may be used to evaluate vessels further away from the heart, such as in the head or connecting to the kidneys.
#enpp1deficiency #abcc6deficiency #gaci #raredisease #arterialcalcification
Raelynn's mother shares, "Our sweet girl is missed everyday. She fought hard for 6 months. 6 months I got to hold her in my arms and love her. Now it's 6 years that she's been carried in our hearts."
#enpp1deficiency #gaci #raredisease #arterialcalcification
Today we wish a happy 7th Birthday to Sir'Savion! He has battled many complications as a result of GACI and is a warrior through and through!
#abcc6deficiency #gaci #arhr2 #raredisease #circulatinghope #arterialcalcification
Today we remember sweet Arden on what should be her 2nd birthday. Arden fought bravely, surrounded by those her love her, but her fight against GACI ended when she was just shy of 7 months old.
#enpp1deficiency #gaci #arhr2 #raredisease #arterialcalcification #rickets
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