Top Tweets for #Bach2
Paper identifies (3) features of better T-cell fitness:
1. Restrained chronic #TCR signalling
2. Avoidance of #NFAT→#TOX/#NR4A exhaustion
3. Preservation of #BACH2/memory-state programs
These align very well w/ effects of selective #ITK inhibition and paper somehow misses this connection.
Paper explicitly argues for an optimal TCR signalling window, avoiding chronic/high-intensity TCR signalling which is a core exhaustion driver. Concept fits #soquelitinib particularly well as it allows this signal modulation.
I modified image from paper to show central role ITK plays in Signal 1 TCR signaling and how it can effect key downstream pathways: NF-κB, AP-1, NFAT.
Review @sigtrans_sttt
T cell senescence and exhaustion: molecular mechanisms and immune rejuvenation for cancer immunotherapy
https://t.co/oqmplU3HqF
$CRVS oral ITKi #soquelitinib dual effect for high efficacy + durability seen in AD:
1. Initial: Direct Suppression of #Th2/#Th17 signaling main MOA
2. Secondary: SQL Increases #BACH2 may be the MOST important durability MOA component of SQL acting as switch to increase stable FOXP3+ iTregs
Paper showing BACH2 may be a novel therapeutically accessible “cell-fate controller” capable of making induced regulatory T cells (iTregs) more stable and clinically useful
https://t.co/kAaNsXTzYZ
(this is what soquelitinib new SID data showed, novel therapeutic effect)
Corvus SID presentation w/ SQL increasing BACH2 and soquelitinib switching Tregs from Th17
https://t.co/5kcSF8lWeX
Concluding thoughts:
Soquelitinib appears to be the first clinical-stage oral small molecule showing human evidence of engagement of BACH2, an exciting new target w/ therapeutic potential for more effective immune-modulating therapies and improved patient outcome
SQL raises BACH2 in iTregs, reducing pathogenic/inflammatory Th17/RORγt activity, and promotes persistent iTreg expansion that may support durable control of autoimmune disease
A great piece in ACIR discussing the there papers on #BACH2 dosing for T cell therapy of cancer recently out in @NatImmunol https://t.co/7jyY1laWNL
What are the characteristics of lymphocytes that prolong #atopic #dermatitis? The presence of T cells with low-levels of #Bach2 contributes to the worsening and/or prolongation of allergic dermatitis symptoms. https://t.co/YaCxQUBtA3
@QI_Tsinghua’s team discovers that B cells epigenetically record stimulation history, which controls the balance of #BLIMP1 and #BACH2 and dictates how likely memory B cells become plasma cells upon restimulation. #InnovativeTsinghua @Nature More: https://t.co/5BpNpXGKpN
Today's #GeneOfTheDay is #Bach2. Human diseases associated with this gene include Immunodeficiency 60 and Autoimmunity (IMD60). Mice with this gene inactivated exhibit abnormal immune cell activity, hyperactivity and thrombocytosis. More data here: https://t.co/7rk8ToWOd6.
Super-killer CTLs are generated by single gene deletion of Bach2
Philippa R. Barton, Gillian M Griffiths, and Colleagues
#CTL #BACH2 #cytotoxicity
https://t.co/VcAcpD6U3g
We are back at City Hall!
Rascal presents “Brawl at City Hall II”
Featuring @RobbieEagles_
Also featuring the rematch between @MatDiamond and @DunedooDazza
Tickets in bio —-> #BACH2
Offre de #stage pour #étudiants #Bach2 #MGE2 #césure @ESCClermont
Si les questions de #mobilité #innovation #territoire #navetteautonome vous intéressent, postulez !
N°2 : site de #Néris #Montluçon
https://t.co/10fpfYCGlQ
Offre de #stage pour #étudiants #Bach2 #MGE2 #césure @ESCClermont
Si les questions de #mobilité #innovation #territoire #navetteautonome vous intéressent, postulez !
N°1 : site de #Gergovie
https://t.co/yBAwZmW45v
Today, I've used #BeautifulPeople by Ed Sheeran, with my #Bach2 class. They are as beautiful as the two protagonists. Simple people, authentic ones vs appearance. 😃 https://t.co/kKRvTianPt
Preparing sessions for next week with my #Bach2 I discover a video about bees and their importance for the Planet. Hope my students may find it as relevant and interesting as I do. 🌏🌺🐝 #Teaching #Sustainability @future_spain
Mis amigas hicieron tan buen team que ya prometimos celebrar el aniversario de este viaje dentro de un año 🇲🇽✨🥳
#LMP2A
#Latentmembraneprotein2A
#EBウイルス の感染により発現する #EBウイルス由来膜タンパク質
通常のEBウイルス感染B細胞では
#胚中心B細胞
https://t.co/VGaQ4O9olx
においてのみ発現
#BCRシグナル
https://t.co/jyJ8qzppck
を模倣し、B細胞の生存を促進することが明らかとなっていた
⇨続く
We identify #BACH2 as a susceptibility locus for postoperative recurrence of Crohn's disease in our cohort. https://t.co/Rzxg6vY8vj @UAlberta_DoM
Nyt kelpaa vähän paukutella henkseleitä: paremman puoliskon #postdoc-kauden #tutkimus julkaistu @NatImmunol -lehdessä! #immunologia #BACH2 https://t.co/UQnoD7FYa4
Human BACH2 immunodeficiency illustrates an association between super-enhancers and haploinsufficiency https://t.co/Wd4qkfl55N
#ImmunoDeficiency | #BACH2 association with SuperEnhancers | Afzali @NIH & Cooper @imperialcollege @NatImmunol https://t.co/irh9K39ljr
#ImmunoDeficiency | #BACH2 association with SuperEnhancers | Afzali @NIH & Cooper @imperialcollege @NatImmunol https://t.co/fgNn8u3Rtw
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