Top Tweets for #BioItaLEE
Die frühe Dynamik von ctDNA scheint ein vielversprechender Surrogat-Biomarker für die Behandlung zu sein.
#ribociclib #bioitalee #cdk #brustkrebs #hr+
https://t.co/1JRNAdibJW
The #BioItaLEE results in @AACR CCR establish a "One-Month Rule" for 1L ribociclib + letrozole. Achieving ctDNA clearance by C2D1 correlates with a 56% reduction in progression risk (HR=0.44), while persistent TP53 or MYC alterations identify primary refractory disease months before the first scan.
While the prognostic value is now settled, the predictive value of escalation is the new frontier. We must prove that intervening at C2D1 improves outcomes vs. waiting for radiographic progression. Next step: "Molecular Switch" trial designs using C2D1 non-clearance as a randomized trigger for escalation.
cc: @OncoAlert @h_rugo @dr_p_tarantino @AneesChagpar @NMatchar @SABCS @ER_ClinOnc
#OncTwitter #BCSM #BreastCancer #PrecisionMedicine #ClinicalTrials #ctDNA #MedEd
Role of ctDNA in predicting the outcome of patients with hormone receptor–positive, HER2-negative advanced breast cancer treated with first-line ribociclib and letrozole: BioItaLEE trial https://t.co/Ztww0Rq1aB
Lo studio BioItaLEE rappresenta “un segnale di vitalità della ricerca del nostro Paese, che dimostra di saper coinvolgere moltissimi centri in sperimentazioni complesse.” @SCinieri
https://t.co/jDOPwIOG4Z
#ricercaoncologica #aiom #bioitalee
#ASCO22 | #BioItaLEE è uno studio condotto per identificare potenziali biomarcatori in biopsia liquida per una combinazione di farmaci (#ribociclib e #letrozolo) e capire quali pazienti con #breastcancer HR+/HR2- traggono i maggiori benefici. @BianchiniGP
https://t.co/AudTdmZbOi
Enlightening data coming from the #BioItaLEE study on the longitudinal multiparametric #LiquidBiopsy characterization of #metastatic #BreastCancer. #ctDNA and #TKa are independent features that could be combined for a real-time definition of treatment benefit. #ASCO22 #bcsm #MBC
Presentati oggi al Congresso @ASCO i primi risultati dello studio #BioItaLEE, condotto in Italia e incentrato sulle potenzialità prognostiche e predittive della combinazione di due biomarcatori nelle pazienti con #tumore al #seno HR+/HER2-. #ASCO22
https://t.co/9umwFkW34G
He did it again @BianchiniGP 😉Italian research at its best #BioItaLEE @LMalorni @GraziaArpino #MichelinoDeLaurentiis 👏🏼 🇮🇹
General session 3 at #SABCS21: super 2nd oral presentation by the great @BianchiniGP of #BioItaLEE trial showing prognostic value and dynamics of #ctDNA in #HR+/#HER2- advanced #BreastCancer patients treated with 1st line #ribociclib and #letrozole
@OncoAlert #bcsm #ItalianPride
Very interesting results of the 🇮🇹 BioItaLEE study by @BianchiniGP @SABCSSanAntonio
🩸 ctDNA clearance: ⬇️ risk of progression
Could we use ctDNA monitoring not only for prognostic, but also to detect emerging targetable mutations and switch treatment accordingly? #SABCS21
General session 3 at #SABCS21: super 2nd oral presentation by the great @BianchiniGP of #BioItaLEE trial showing prognostic value and dynamics of #ctDNA in #HR+/#HER2- advanced #BreastCancer patients treated with 1st line #ribociclib and #letrozole
@OncoAlert #bcsm #ItalianPride
Alcuni posters da non perdere☝️#ESMO21
👉Association of QOL with OS in the #MONALEESA-3 and -7 trials
👉Thymidine kinase 1 activity as prognostic and predictive biomarker in the #BioItaLEE trial
👉Therapies after Alpelisib in the #SOLAR-1 trial
@BCancerAcademy @myESMO
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