Top Tweets for #CDC42
When a single variant rewires an inflammatory pathway across 3 generations.
Fascinating work in @SciImmunology revealing how a #CDC42 variant drives #pyrin hyperactivation through the B30.2 domain, uncovering molecular mechanisms of human #autoinflammation.
Congratulations @sethmasters and colleagues!
https://t.co/oKtU9GDlmu
#Immunology #RareDisease #HumanGenetics
A CDC42 variant, which presents across three generations of a family with #autoinflammation, drives #pyrin hyperactivation by enhancing interactions via the B30.2 domain. @sethmasters
Learn more in Science #Immunology: https://t.co/0wuLBUYj1j
A new Science #Immunology study characterizes 265 mutations found in patients with familial Mediterranean fever, providing insight into how #CDC42 variants can enhance #pyrin and inflammasome activation during autoimmune disorders. https://t.co/jQiPXlSvlr
Arp2/3-dependent #endocytosis ensures #Cdc42 oscillations by removing Pak1-mediated negative feedback. From Marcus Harrell, Ziyi Liu, Maitreyi Das and colleagues: https://t.co/5ahvt7he86
📕 Part of “Collective Behaviors and Self-Organization in Cells”: https://t.co/opU1VabATh
Dr Honorine Ward highlights Adam Sateriale & colleagues’ recent @cellhostmicrobe article on a #virulence factor, #Cryptosporidium #MVP1, modulating #intestinal #microvilli by interacting with host #EBP50 & #CDC42. @TuftsMedicalCtr @TheCrick
https://t.co/oauRpKXVQF
Happy to present our story on how #actin and #CDC42 regulate #ectocytosis and #ciliaryvesicle shedding in #BardetBiedlSyndrome at 30th Cytoskeletal Club in Liblice🌞
Having cilialicious time in Dublin @EuroCilia2024 presenting our work on #ectocytosis #cdc42 #cilia #BardetBiedlSyndrome Thank to all the cilia lovers for great feedback 🤩 🥂
.@sciencemagazine highlight the recent study by @DasLab_Pombe and colleagues showing that #endocytosis regulates the oscillatory activity of #Cdc42 during the polarized growth of fission yeast: https://t.co/bQxNZkJdmv
Original study: https://t.co/XE2uPG27VK
.@sciencemagazine highlight the recent @JCellBiol study by @DasLab_Pombe and colleagues showing that #endocytosis regulates the oscillatory activity of #Cdc42 during the polarized growth of fission yeast: https://t.co/clFWcH5eYk
Original study: https://t.co/zQlX6caauX
Video shows GFP-CDC42b in migrating #astrocytes. @yamini_ravichan, @etiennemannevil et al. show that the distinct localization of #CDC42 isoforms is responsible for their specific functions during #migration. https://t.co/okSOyap4Wm
#Polarity #motility #Development
The distinct localization of #CDC42 isoforms is responsible for their specific functions during #migration, say Yamini Ravichandran (@yamini_ravichan), Jan Hänisch, Kerren Murra, Sandrine Etienne-Manneville @etiennemannevil @institutpasteur & colleagues: https://t.co/TjjykzAwkD
New study by Ravichandran (@yamini_ravichan), Hänisch, Murra et al. @etiennemannevil lab @institutpasteur illustrates how the specific subcellular localization of each #CDC42 isoform is responsible for their very different functions. https://t.co/tLh6XTBL5u
#Polarity #Migration
🎉Honored to be cited in @AgingCell
‼️Prof. Lu Zhang’s team’s results indicate that impaired #Cdc42 signaling regulated by #D2R plays an important role in spine loss and behavioral deficits in #PD.
@Brain_VTA offers AAV services
➡️
https://t.co/0VFK3uLWQQ
Check out the preprint by Sophie Tschirpke, Werner Daalman and myself where we use in vitro reconstitution to show that the GEF Cdc24 and the GAP Rga2 synergistically regulate the small GTPase #Cdc42 [1/n]
https://t.co/h24s1wpMA9
Are you a (bio)phycisist or (bio) chemist struggling with #protein_purification? Which tag to use, and where to put it? How to cleave of you tag, and how to check for activity?
Check out our guide for non-experts based on our experiences with #Cdc42:
https://t.co/ir0Dc66Bbj
Kreider-Letterman, @RhoPower et al. show that ARHGAP17 regulates the spatiotemporal activity of #Cdc42 at #invadopodia. https://t.co/xgqmJhh6ml
From our #Cancer Cell Biology collection: https://t.co/konGqg9mVo
#AACR23
Model of ARHGAP17 function in invadopodia. Kreider-Letterman, Garcia-Mata @RhoPower et al. describe a novel mechanism for the regulation of #Cdc42 dynamics at #invadopodia by the Cdc42-GAP ARHGAP17 https://t.co/xgqmJhh6ml
#Cytoskeleton #Migration #motility #Cancer
ARHGAP17 regulates the spatiotemporal activity of #Cdc42 at #invadopodia, say Gabriel Kreider-Letterman, Rafael Garcia-Mata @RhoPower and colleagues https://t.co/xgqmJhh6ml
#Cytoskeleton #Migration #motility #Cancer
Image shows cortical localization of Rga3, Rga4, and Rga6 in outgrowing cells. Wenfan Wei, Biyu Zheng, Chuanhai Fu and colleagues @USTCGlobal show that the #Cdc42 GAP Rga6 promotes monopolar outgrowth of spores. https://t.co/H0gwRHS2nK
#Polarity #Genetics #Cytoskeleton #GTPases
Regulatory mechanism of Cdc42p turnover, and its impact on fMAPK pathway activity. Beatriz González and Paul Cullen @CullenLab_UB show that regulation of Cdc42 protein turnover modulates the filamentous growth MAPK pathway. https://t.co/y8h480znUm
#Cdc42 #GTPases #CellSignaling
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