Top Tweets for #CodeBreak300
#Sotorasib (+ Panitumumab) now @US_FDA approved for mCRC w/ KRAS G12C after 5FU, Oxali, and Irin based off #CODEBREAK300:
- 960mg QDay
- PFS 5.6mos (vs 2mos), ORR 26%, OS not significant
- Adagrasib (+ Cetux) ✅ based off #KRYSTAL1
#gism #OncTwitter #MedTwitter #crcsm

FDA approves sotorasib with panitumumab for KRAS G12C-mutated colorectal cancer
https://t.co/Ile5FhDjjX
#OCENewsBurst
#ESMO23 GI Highlights w/ @rachnatshroff
- #CodeBreak300
- #CABINET
- #GASTFOX
Full 📢:
- https://t.co/oO0ErxWu5B
- https://t.co/bqb1o0FiD7
- Also on the “Oncology Brothers” podcast
#MedTwitter #OncTwitter @myESMO #gism #crcsm @TargetedOnc
#ESMO23 | @FilippoPietran4 reports on key results on the #CodeBreak300 phase 3 study: sotorasib + panitumumab vs standard-of-care for chemorefractory KRAS G12C-mutated #mCRC
#ESMO23 | @ChiaraCrem1: “The combination of sotorasib and panitumumab will likely become a new standard of care for KRAS G12C mutant #mCRC patients”.
#CodeBreak300
@FilippoPietran4 @myESMO @GillSharlene @CarmeloPozzo @IstTumori @Unipisa
@FilippoPietran4 excellent talk!!! Soto+Pani improves PFS and RR vs standard therapy in chemorefractory KRAS G12C mCRC patients. Fil you are the number one #ESMO23 #codebreak300 #nejm

#ESMO23
📢Presidential2 @myESMO
#CODEBREAK300 Sotorasib 960mg/240mg + Panitumumab vs IC TAS/Rego for #KRASG12C #CCR
🗣️ @FilippoPietran4
📌 mPFS 5.6m/3.6m HR 0.49/0.58
📌 ORR 26/6% mDor 5.8
☣️ >G3 35/30%
@ASCO @OncoAlert @OncBrothers @_SEOM
Discussed by Dr. Koopman

@FilippoPietran presenting the #CodeBreak300 with EGFR/KRAS double 🎯🎯 & dose-optimization clinical trial in advanced #CRC at #ESMO23
👇🏻👇🏻👇🏻

#ESMO2023 Late Breaking Abstracts
#CodeBreaK300 - Sotorasib plus panitumumab versus standard-of-care for chemorefractory KRAS G12C-mutated metastatic colorectal cancer
⬆️ PFS
⬆️ efficacy signal in higher dose sotorasib (960 mg)
⏱️ OS pending

< 3 weeks to #ESMO23, here is a📝 of 🔑abstracts for general onc that could change our SoC!
- #ALINA
- #LIBRETTO431
- #TROPIONLung01
- #MARIPOSA
- #Ev302
- #CM901
- #LITESPARK005
- #KN756
- #CABINET
- #CODEBREAK300
#BCSM #GISM #LCSM #MedTwitter #GUSM #OncTwitter @myESMO

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