Top Tweets for #Compstatin

over 2 years ago

Happy 70th @LambrisJD!! Here holding his "brainchild" #compstatin #Cp40 right next to its target #C3, the complement protein whose evolution, structure and many functions John has pioneered for more than 40 yrs! @AegeanConf @ComplementSoc

dmastellos's tweet photo. Happy 70th @LambrisJD!!
Here holding his "brainchild" #compstatin #Cp40 right next to its target #C3, the complement protein whose evolution, structure and many functions John has pioneered for more than 40 yrs! @AegeanConf @ComplementSoc https://t.co/mD0eyoyX3A

1

22

3

0

666

Christina Lamers @ChristinaLamers

almost 3 years ago

Glad to see the two Phase III studies of #Syfovre in #GA patients completed and published! Witnessing the evolution of #Compstatin analog Cp05, discovered in my lab @Penn back in 2006, all the way from bench to bedside has been such a gratifying experience https://t.co/RpP7p1U33C

0

12

0

508

Martin Smieško @MSmiesko

about 4 years ago

Peculiarities of Complement C3 inhibition explained @NatureComms https://t.co/BxJZVRuNqX #complement #compstatin #complement #CompChem #DrugDesign

0

2

1

0

about 4 years ago

Happy to see our study published in @NatureComms on the fascinating cyclic peptide #compstatin Cp40 and its molecular determinants to high affinity. Such a great collaborative work with Daniel Ricklin, @LambrisJD and Piet Gros labs. #research #macrocycles #peptides #WomenInSTEM

about 4 years ago

Excited to share the latest chapter in the #compstatin saga now out in @NatureComms Great collaboration with Daniel Ricklin’s & Piet Gros’ groups! Insight into mode-of-action and structural determinants of the compstatin family! https://t.co/SG3BZBnygR

0

22

3

0

5

25

2

0

about 4 years ago

Excited to share the latest chapter in the #compstatin saga now out in @NatureComms Great collaboration with Daniel Ricklin’s & Piet Gros’ groups! Insight into mode-of-action and structural determinants of the compstatin family! https://t.co/SG3BZBnygR

0

22

3

0

about 4 years ago

Delighted to see our work finally out in @ScienceAdvances!New mechanistic and biological insights into systemic C3 inhibition with #compstatin #AMY101 in severe #COVID19 Clinical effort led by @PSkendros, Ritis & an international team of collaborators! https://t.co/t7vUGfLWfY

4

21

9

0

about 4 years ago

From our special issue on #C3 therapeutics: #Compstatin-based inhibitors are poised to revolutionize C3-targeted #therapy for #AMD #GA & other #ocular diseases! To get a grasp on the latest developments in this rapidly evolving field check out our review: https://t.co/AUSYEECXOM

0

5

1

0

over 4 years ago

Happy to share article #2 of our special issue w/ @dmastellos on #C3 #therapeutics! Mechanistic-clinical insights and prospects of C3-targeted host modulation with #compstatin-based #AMY101 in #periodontal & #peri_implant inflammatory diseases #oralhealth https://t.co/yYGbWLFAWK

0

9

5

0

over 4 years ago

Our latest review on the #compstatin class of clinical #C3 inhibitors now out @TrendsinPharma! With insights on #structure-#activity, #mode of action #PK/#PD aspects & the emerging therapeutic potential of #compstatins in chronic neurodegenerative diseases https://t.co/4BxNzz31P6

1

15

5

1

0

almost 5 years ago

Check out this video to learn more about the current state of play in #ComplementTherapeutics, the clinical progress of therapeutic #C3 inhibition, the challenges & misconceptions and the emerging prospects of #compstatin inhibitors in various indications https://t.co/xcr56pn2rL

0

16

4

0

almost 5 years ago

Complement C3 inhibition by #compstatin Cp40,but not C5 inhibition, broadly attenuates air-induced #thromboinflammation in a whole blood model of venous #air #embolism Great study @J_Immunol by Storm, @LambrisJD, Mollnes et al @ncrg_no #complementbiology https://t.co/KLgi9wn6bI

0

11

5

1

0

about 5 years ago

A game-changing development in the #ComplementTherapeutics field! #Compstatin therapeutic #APL-2 met its primary endpoint in a Ph III trial in #GA #dryAMD. https://t.co/bIN9ahtpFV See analysis by Umer Raffat and Jonnathan Miller below.

LambrisJD's tweet photo. A game-changing development in the #ComplementTherapeutics field! #Compstatin therapeutic #APL-2 met its primary endpoint in a Ph III trial in #GA #dryAMD. https://t.co/bIN9ahtpFV See analysis by Umer Raffat and Jonnathan Miller below. https://t.co/GGeTSjrQCY

1

11

6

0

over 5 years ago

@dmastellos Thank you Dimitri, Daniel, Georgia & Arvind for this emotional overview of the #compstatin story! This has only been possible through the insightful contributions of more than 130 scientists across the globe and the generous support of many funding agencies over the last 25 yrs!

0

10

1

0

aHUS Alliance Action @aHUSAllianceAct

over 5 years ago

A brief history of the #compstatin class of #complement #C3 inhibitors and...a special tribute to the visionary @LambrisJD & all colleagues that contributed to this fascinating scientific journey that brought C3 inhibition to the clinic! Happy 67th John! https://t.co/LMW1f893Xg

3

26

8

4

0

over 5 years ago

Great news for those with the #RareDisease #PNH, congratulations to all involved with #Compstatin #drugdiscovery & #clinicaltrials. We await positive progress on new #drugs to be approved for atypical HUS. #complement #aHUS #pharma

over 5 years ago

Thrilled that a #C3 therapeutic based on #compstatin discovered in our lab at #Penn, is approved by FDA for #PNH treatment https://t.co/q0foFPwctU

0

35

11

1

0

1

4

0

over 5 years ago

Here's to the first #FDA-approved complement #C3 inhibitor! A landmark decision that broadens the #ComplementTherapeutics spectrum! Massive congrats to @LambrisJD the discoverer of #compstatin-based C3 therapeutics for paving the way for this clinical approval! @ComplementSoc

over 5 years ago

Thrilled that a #C3 therapeutic based on #compstatin discovered in our lab at #Penn, is approved by FDA for #PNH treatment https://t.co/q0foFPwctU

0

35

11

1

0

1

18

6

0

over 5 years ago

Thrilled that a #C3 therapeutic based on #compstatin discovered in our lab at #Penn, is approved by FDA for #PNH treatment https://t.co/q0foFPwctU

0

35

11

1

0