Top Tweets for #Compstatin
Amid the dust settling from the 'explosion' of clinical approvals, here's our spotlight w/@LambrisJD on the first ever therapy for patients with geographic atrophy, the #compstatin based #C3 targeted drug #Syfovre #pegcetacoplan Now out in @TrendsinPharma https://t.co/JzAdCa1fv5

Happy 70th @LambrisJD!!
Here holding his "brainchild" #compstatin #Cp40 right next to its target #C3, the complement protein whose evolution, structure and many functions John has pioneered for more than 40 yrs! @AegeanConf @ComplementSoc

Glad to see the two Phase III studies of #Syfovre in #GA patients completed and published! Witnessing the evolution of #Compstatin analog Cp05, discovered in my lab @Penn back in 2006, all the way from bench to bedside has been such a gratifying experience
https://t.co/RpP7p1U33C
Peculiarities of Complement C3 inhibition explained @NatureComms https://t.co/BxJZVRuNqX #complement #compstatin #complement #CompChem #DrugDesign
Happy to see our study published in @NatureComms on the fascinating cyclic peptide #compstatin Cp40 and its molecular determinants to high affinity. Such a great collaborative work with Daniel Ricklin, @LambrisJD and Piet Gros labs. #research #macrocycles #peptides #WomenInSTEM
Excited to share the latest chapter in the #compstatin saga now out in @NatureComms Great collaboration with Daniel Ricklin’s & Piet Gros’ groups! Insight into mode-of-action and structural determinants of the compstatin family!
https://t.co/SG3BZBnygR
Excited to share the latest chapter in the #compstatin saga now out in @NatureComms Great collaboration with Daniel Ricklin’s & Piet Gros’ groups! Insight into mode-of-action and structural determinants of the compstatin family!
https://t.co/SG3BZBnygR
Delighted to see our work finally out in @ScienceAdvances!New mechanistic and biological insights into systemic C3 inhibition with #compstatin #AMY101 in severe #COVID19 Clinical effort led by @PSkendros, Ritis & an international team of collaborators!
https://t.co/t7vUGfLWfY
Happy to share article #2 of our special issue w/ @dmastellos on #C3 #therapeutics! Mechanistic-clinical insights and prospects of C3-targeted host modulation with #compstatin-based #AMY101 in #periodontal & #peri_implant inflammatory diseases
#oralhealth https://t.co/yYGbWLFAWK
Our latest review on the #compstatin class of clinical #C3 inhibitors now out @TrendsinPharma! With insights on #structure-#activity, #mode of action #PK/#PD aspects & the emerging therapeutic potential of #compstatins in chronic neurodegenerative diseases
https://t.co/4BxNzz31P6
Check out this video to learn more about the current state of play in #ComplementTherapeutics, the clinical progress of therapeutic #C3 inhibition, the challenges & misconceptions and the emerging prospects of #compstatin inhibitors in various indications https://t.co/xcr56pn2rL
Complement C3 inhibition by #compstatin Cp40,but not C5 inhibition, broadly attenuates air-induced #thromboinflammation in a whole blood model of venous #air #embolism Great study @J_Immunol by Storm, @LambrisJD, Mollnes et al @ncrg_no #complementbiology https://t.co/KLgi9wn6bI
A game-changing development in the #ComplementTherapeutics field! #Compstatin therapeutic #APL-2 met its primary endpoint in a Ph III trial in #GA #dryAMD. https://t.co/bIN9ahtpFV See analysis by Umer Raffat and Jonnathan Miller below.

@dmastellos Thank you Dimitri, Daniel, Georgia & Arvind for this emotional overview of the #compstatin story! This has only been possible through the insightful contributions of more than 130 scientists across the globe and the generous support of many funding agencies over the last 25 yrs!
A brief history of the #compstatin class of #complement #C3 inhibitors and...a special tribute to the visionary @LambrisJD & all colleagues that contributed to this fascinating scientific journey that brought C3 inhibition to the clinic! Happy 67th John! https://t.co/LMW1f893Xg
Great news for those with the #RareDisease #PNH, congratulations to all involved with #Compstatin #drugdiscovery & #clinicaltrials. We await positive progress on new #drugs to be approved for atypical HUS. #complement #aHUS #pharma
Thrilled that a #C3 therapeutic based on #compstatin discovered in our lab at #Penn, is approved by FDA for #PNH treatment https://t.co/q0foFPwctU
Here's to the first #FDA-approved complement #C3 inhibitor! A landmark decision that broadens the #ComplementTherapeutics spectrum! Massive congrats to @LambrisJD the discoverer of #compstatin-based C3 therapeutics for paving the way for this clinical approval! @ComplementSoc
Thrilled that a #C3 therapeutic based on #compstatin discovered in our lab at #Penn, is approved by FDA for #PNH treatment https://t.co/q0foFPwctU
Thrilled that a #C3 therapeutic based on #compstatin discovered in our lab at #Penn, is approved by FDA for #PNH treatment https://t.co/q0foFPwctU
Thrilled that a #C3 therapeutic based on #compstatin discovered in our lab at Penn, shows impressive clinical results in comparison to #eculizumab and gets close to approval, validating the broader efficacy of #C3 vs #C5 inhibition in PNH https://t.co/ZYa4359Jlx
@2Scottish Yes!!! #Compstatin is what I thought could be appropriate treatment for complications associated with #COVID19 & #influenza. :)
#Platelet research matters!!!
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