Top Tweets for #Disitamab
🌟 #Disitamab Vedotin + #Toripalimab in #HER2-Expressing Advanced Urothelial Cancer
NEJM, Oct 2025 RC48-C016🌟
🔶 Phase III trial in previously untreated HER2-expressing (IHC 1+/2+/3+) locally advanced or metastatic urothelial cancer
🔶 PFS doubled vs chemotherapy: 13.1 vs 6.5 months (HR 0.36; P<0.001)
🔶 Overall survival significantly improved: 31.5 vs 16.9 months (HR 0.54; P<0.001)
🔶 Objective response rate: 76.1% vs 50.2% with chemotherapy
🔶 Favorable safety profile: grade ≥3 TRAEs 55.1% vs 86.9% with chemo
🔶 Positions ADC + PD-1 combination as a new first-line standard for HER2-expressing advanced urothelial cancer. @DrChoueiri @PGrivasMDPhD
@Sonpavde @TiansterZhang
@DrDanielHeng @Silke_Gillessen
@montypal @drenriquegrande
@shilpaonc @AndreaNecchi @neerajaiims
@NEJM @theNCI @ASCO @myESMO @OncoAlert #MedicalWatchPapers #UrothelialCancer #BladderCancer #HER2 #ADC #Immunotherapy #PrecisionOncology #OncoTwitter
https://t.co/DZKCFrpsVY
#Disitamab #vedotin-#tislelizumab combination showed promising tumor downstaging (70%) and nephron preservation (75%) in high risk #UTUC with favorable safety profile w/ #DrJiweiHuang #ESMO25
@TiansterZhang
phase II RC48-C017 trial- #perioperarive #disitamab #vedotin + toripalimab for #MIBC showed promising efficacy with significant #pCR, particularly high #HER2 expressing cohort (overall 63.6%, 84.6% in HER2 IHC3). Safely profile manageable, OS remains immature Dr.Xinan Sheng
Dr. Elizabeth Plimack (@ERPlimackMD) highlighted the progress of #ADCs in #bladdercancer research. Updates on the effectiveness of #trastuzumab #deruxtecan and #disitamab #vedotin anchor her discussion. Learn more: https://t.co/FuANdIOxv7
Interested in new treatments being developed for advanced (urothelial) bladder cancer? - Earle Burgess
#Cancer #BladderCancer #Disitamab #UrothelialCancer #Vedotin #OncoDaily #Oncology
https://t.co/syda2NdIKf
#Disitamab vedotin (trade name: #Aidexi®, research code: #RC48) was approved to market for the treatment of locally advanced or #MetastaticGastricCancer in China. https://t.co/GtNGqRKbzZ
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