Top Tweets for #DownwardLab
The past years at @TheCrick have been an incredible journey. I’m immensely grateful to my mentors and colleagues for their support and collaboration.
It would be impossible to mention everyone here, but I particularly want to thank @JulianDownward and the #Downwardlab.
Many thanks to Megan Cole, @F_vanMaldegem, @molina_arcas, @CharlesSwanton, @TheCrick, @CRUKresearch, @HorizonEU, #DownwardLab
Interested on how to combine #KRAS inhibitors with immunotherapies? Check out the last paper of the #Downwardlab and @F_vanMaldegem
https://t.co/n1B55vWxks
T cells receive regulatory signals from close neighbours, through ligand-receptor interactions and cytokines. Therefore we dived into the local neighbourhoods of CD8 T cells to investigate why a lung cancer model was resistant to KRAS-G12C-i + a-PD1.
Fantastic opportunity to join the #downwardlab! Great science with amazing people. I couldn’t recommend it more (a bit biased here). Please share!
We are looking for a post-doc with a background in immunology to work on the impact of RAS oncogenic signaling on the interaction of lung cancers with the immune system. Fully funded four year position at Francis Crick Institute in London. #Crick https://t.co/RFbqyRoLft
Check out the last paper from the #downwardlab. It is great to see it finally out. Congratulations @gorantomich and the rest of the authors
Just published in @CellReports #OpenAccess. We show that the palmitoyl transferase ZDHHC20 mediates metastasis of pancreatic cancer in vivo. https://t.co/vEOuZ5h3yk
Fantastic session highlighting the breadth of cancer immunology questions being addressed by early-stage researchers at the future leaders lightning talk session at #CancerHostTI24 (NC) ⚡️⚡️
It was a pleasure to present the #downwardlab data of how we can engage the immune system to target #KRAS G12C inhibitor resistant cells at #AACR2024 Work led by the talented @MonaTomaschko
Here at #AACR24 we're ready to hear from @molina_arcas on investigating therapeutic strategies to promote immune rejection of KRASG12C inhibitor-resistant subpopulations in lung #cancer 🦠👩🔬
@TheCrick | #CRUKfunded
Another preprint from the #Downwardlab! Combining RAS G12C(ON) and SHP2 inhibition sensitizes immune cold lung tumors to PD1 inhibition. Great work by @Anastap78 and co.!
Our last preprint is now online #Downwardlab @JulianDownward. Combining RAS G12C(ON) and SHP2 inhibitors we sensitise anti-PD1 refractory tumours to immune checkpoint blockade. Led by the talented @Anastap78 https://t.co/cfyM8qKdvy
Our last preprint is now online #Downwardlab @JulianDownward. Combining RAS G12C(ON) and SHP2 inhibitors we sensitise anti-PD1 refractory tumours to immune checkpoint blockade. Led by the talented @Anastap78 https://t.co/cfyM8qKdvy
In an international collaboration between @bivonaLabUCSF and @HarrisLabUTHSA in the USA and @Drmcaswell @SwantonLab and #DownwardLab at the Crick, researchers found that the mutagenic enzyme APOBEC3B can contribute to targeted cancer therapy resistance
https://t.co/0kPBfRjK9w
The applications for the 2024 PhD programme at the Francis Crick Institute are opened! And the #Downwardlab has one position.
Fantastic PhD programme positions open at the Francis Crick Institute, including one in my lab.
Check out this work led by @jboumelha describing COX2 as a mediator of immune evasion in NSCLC. Another must-read from the #downwardlab!
Our latest preprint is now online @JulianDownward ! Using in vivo CRISPR screening we show that oncogenic KRAS signalling promotes COX2/PGE2 signalling in NSCLC driving immune evasion and immunotherapy resistance. https://t.co/mkag4Brlaw
Just started as a postdoc in @JulianDownward laboratory at @TheCrick 💂🏼♀️Very much looking forward to be part of the lab and contribute to the improvement of lung cancer therapies.
Important study from the @SwantonLab on how air polutants promote lung cancer in non-smokers. With the collaboration of the #Downwardlab. Congratulations to everybody involved!
Today our important study on air pollutants in the promotion of lung cancer has been published in @Nature led by @WillHilliam @LimEmilia @DrClareWeeden @SwantonLab ...Thread below🧵https://t.co/q1ICykmVox
Check out the new preprint from the #Downwardlab
Interested in how cancers control the immune system? We have a PhD studentship open at the Francis Crick Institute in London to study KRAS oncogene mutant lung cancer and immunotherapy. Apply to join our team by 10 November. #Downwardlab @TheCrick https://t.co/GUVZAhPIMu
Great resource for the lung cancer community! The #downwardlab has generated an immunogenic mouse model of KRAS-G12C lung cancer to study responses to targeted drugs and ICB, check it out!
Lots more on the way using this preclinical model so stay tuned ! Thanks to everyone else involved @mattcoelho3 @EdurMugarza @molina_arcas @harrislab @CharlesSwanton #Downwardlab
Check out the last work from the #Downwardlab
Our work with @philipeast and @JulianDownward on #KRAS oncogenic signalling and resistance to therapy in lung adenocarcinoma (#LUAD) is out in @NatureComms! Tweetorial 🧵
Please share 🙂
https://t.co/oZAIAcOukO
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