#Exopher - Twitter Hashtag

over 2 years ago

Online now! Yang et al. show that inhibition of early-acting autophagy genes in neurons extend C. elegans lifespan, improve proteostasis, and increase #exopher formation via the autonomous WD40 domain-related function of ATG-16.2. @kumsta @thehansenlab https://t.co/mZD6EzcxyV

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Meghan Lee Arnold @meghanlarnold

over 3 years ago

40 minutes captured and displayed in 4 seconds. How does the neuron lose more than half its volume?!? #exopher #AlzheimersDisease #cellbiology

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Meghan Lee Arnold @meghanlarnold

almost 4 years ago

C. elegans neurons have intermediate filament-bound aggresome organelles. Stress-sensitive. Yes, they can get thrown out of the cell in an exopher, BUT — they also *regulate* general exopher trash ejection. #proteostasis #aggresome #Alzheimers #exopher https://t.co/7ddwxtFIqW

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Meghan Lee Arnold @meghanlarnold

almost 4 years ago

Do you study neurons, neurodegeneration, or aggregate diseases? Check out this preprint on the C. elegans aggresome - a stress-sensitive aggregate containing organelle: https://t.co/7ddwxtFIqW #exopher #Alzheimers #aggresome

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Meghan Lee Arnold @meghanlarnold

almost 4 years ago

Timelapse of an mCherry-tagged neuron (bottom right) featuring a recent exopher. the exopher is being actively degraded — wild tubulations and material transfer. ~3 hours. #exopher #degrading #aggregate #AlzheimersDisease

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Meghan Lee Arnold @meghanlarnold

almost 4 years ago

A neuron throws out its trash …. Then what?? #exopher #neuron https://t.co/0lhGfa1tk9

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Jose Angel Nicolas Avila @NicolasAvilaJA

almost 5 years ago

Recent paper from #Monica_Driscoll lab published in @PNASNews describing how different stress stimuli affect to #exopher formation in neurons from C. Elegans. Also, they provide some data in the molecular machinery involved in these events. Pure gold! https://t.co/vnCLUxoiBB

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Jose Angel Nicolas Avila @NicolasAvilaJA

almost 5 years ago

Very interesting study from @wojtek_pokrzywa lab, introducing novel functions for exophers apart from quality control. Importantly, they confirm the release of aberrant mitochondria through these structures and the connection with autophagy pathway. #exopher field is a THING!

EMBO Reports @emboreports

almost 5 years ago

The August issue is online. Have a read here: https://t.co/3EJ0g1qIal The cover features work by @Michal_R_Turek and @wojtek_pokrzywa @UniWarszawski @IIMCB_Poland and co-workers showing that exophers promote reproductive fitness. -> https://t.co/VcDZ2e0W8n…

emboreports's tweet photo. The August issue is online. Have a read here:
https://t.co/3EJ0g1qIal

The cover features work by @Michal_R_Turek and @wojtek_pokrzywa @UniWarszawski @IIMCB_Poland
and co-workers showing that exophers promote reproductive fitness.
-> https://t.co/VcDZ2e0W8n… https://t.co/Cg8rxIlffL

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Kenneth W Witwer (he/him)

@KennethWWitwer

over 5 years ago

Have a look at this #protocol for #Exopher separation. #ExtracellularVesicles @IsevComms

Jose Angel Nicolas Avila @NicolasAvilaJA

over 5 years ago

You can now find our detailed protocol to purify cardiac #exophers in @STARProtocols . Please, take a look if you are interested in this new type of mechanism of cellular fitness. https://t.co/blhNdEZ6Tj

NicolasAvilaJA's tweet photo. You can now find our detailed protocol to purify cardiac #exophers in @STARProtocols . Please, take a look if you are interested in this new type of mechanism of cellular fitness.
https://t.co/blhNdEZ6Tj https://t.co/o3SmSMW6Y9

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Kenneth W Witwer (he/him)

@KennethWWitwer

over 5 years ago

I really liked Ángel's point about how you just CAN'T afford to lose certain cells like neurons, cardiac cells...so they might be willing to take this drastic step of #exopher release to stay alive and in their role. Really amazing.

. @LiliiaPaniushk1

over 5 years ago

It is amazing how intelligent the body system to get rid of the damaged cellular components properly! I remember my first impression of EV function as 'just to pack some garbadge in '. This JUST is so meaningful and complex. Insightful talk👀 #EVJouranalClub #Exopheres #heart

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Meghan Lee Arnold @meghanlarnold

about 7 years ago

C. elegans neurons have Lewy body- like inclusions that grow with proteostress and regulate trash ejection from the cell. #aggresomes? #exopher #worm19 #850C

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Meghan Lee Arnold @meghanlarnold

over 8 years ago

Check out what my team and I have been up to and read this review on neuronal exophers and protein degradation strategies! #exopher https://t.co/oruwO4Y5iS

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