Top Tweets for #exopher
Online now! Yang et al. show that inhibition of early-acting autophagy genes in neurons extend C. elegans lifespan, improve proteostasis, and increase #exopher formation via the autonomous WD40 domain-related function of ATG-16.2. @kumsta @thehansenlab https://t.co/mZD6EzcxyV
40 minutes captured and displayed in 4 seconds. How does the neuron lose more than half its volume?!? #exopher #AlzheimersDisease #cellbiology
C. elegans neurons have intermediate filament-bound aggresome organelles. Stress-sensitive. Yes, they can get thrown out of the cell in an exopher, BUT — they also *regulate* general exopher trash ejection. #proteostasis #aggresome #Alzheimers #exopher https://t.co/7ddwxtFIqW
Do you study neurons, neurodegeneration, or aggregate diseases? Check out this preprint on the C. elegans aggresome - a stress-sensitive aggregate containing organelle: https://t.co/7ddwxtFIqW #exopher #Alzheimers #aggresome
Timelapse of an mCherry-tagged neuron (bottom right) featuring a recent exopher. the exopher is being actively degraded — wild tubulations and material transfer. ~3 hours. #exopher #degrading #aggregate #AlzheimersDisease
Recent paper from #Monica_Driscoll lab published in @PNASNews describing how different stress stimuli affect to #exopher formation in neurons from C. Elegans. Also, they provide some data in the molecular machinery involved in these events. Pure gold!
https://t.co/vnCLUxoiBB
Very interesting study from @wojtek_pokrzywa lab, introducing novel functions for exophers apart from quality control. Importantly, they confirm the release of aberrant mitochondria through these structures and the connection with autophagy pathway. #exopher field is a THING!
The August issue is online. Have a read here:
https://t.co/3EJ0g1qIal
The cover features work by @Michal_R_Turek and @wojtek_pokrzywa @UniWarszawski @IIMCB_Poland
and co-workers showing that exophers promote reproductive fitness.
-> https://t.co/VcDZ2e0W8n…

You can now find our detailed protocol to purify cardiac #exophers in @STARProtocols . Please, take a look if you are interested in this new type of mechanism of cellular fitness.
https://t.co/blhNdEZ6Tj

I really liked Ángel's point about how you just CAN'T afford to lose certain cells like neurons, cardiac cells...so they might be willing to take this drastic step of #exopher release to stay alive and in their role. Really amazing.
It is amazing how intelligent the body system to get rid of the damaged cellular components properly! I remember my first impression of EV function as 'just to pack some garbadge in '. This JUST is so meaningful and complex. Insightful talk👀 #EVJouranalClub #Exopheres #heart
C. elegans neurons have Lewy body- like inclusions that grow with proteostress and regulate trash ejection from the cell. #aggresomes? #exopher #worm19 #850C
Check out what my team and I have been up to and read this review on neuronal exophers and protein degradation strategies! #exopher
https://t.co/oruwO4Y5iS

Alternative pathways for neurological toxicity over alternate facts. Any day. #exopher #thatwassocool #worm17
#exopher https://t.co/aVvRE1LJzu
Adult neurons from C. elegans extrude membrane-surrounded vesicles that can contain protein aggregates & organelles https://t.co/mtRoldCk3n

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