Top Tweets for #IFNlambda
๐ข a fantastic talk from one of our @drdeannasanter #sisterlabs graduate students @OlamideOgungbo1 talking about the coolest IFNs #IFNlambda and their unique role in #IBD
Our latest paper is now online! We identify #USP22 as a negative regulator of #interferon, #ISG and type III interferon #IFNlambda expression in the control of #SARSCoV2 infection https://t.co/NIzOSwzZbY
#JI_TopRead from Murali Prakriya @NUFeinbergMed: #Histamine and Extracellular #ATP suppress #typeIIFN and #typeIIIIFN release | #IFN #IFNlambda #TLRs #RigI #ReadtheJI https://t.co/JG2Yuow0Nx
Me in COVIDland: so far, itโs like a moderate/bad cold, thanks to my 4 shots. Having OAS1 rs10774671-AA and rs1131454-AA genotypes, I am less likely to clear on my own (paper is coming soon!) and some help was needed. I would take an #IFNLambda shot but for now, Paxlovid it is!
Beyond good and evil: Molecular #mechanisms of type I and III #IFN functions by @adforu & @dowlja11 @OSUWexMed |#BriefReview in #JI_celebratediversity https://t.co/dwlStDiy19 #ReadTheJI #IFNlambda #cytokines
Maybe #IFNb is not the best way to treat #COVID19 patients. Given the mucosal tropism, #IFNlambda could be a better solution. But this requires proper testing.
#interferons & #COVID19: a new #doubleblind #randomised #trial proved no efficacy of subcute #IFNb + deleterious effects in critical patients. This is in total agreement with our findings and predictions https://t.co/ltgKrT4YMX IFN type & location matter! https://t.co/ymtKIYjkci
Summary data is in the press release related to virus clearance with publication hopefully soon. Congrats to all involved to reach this 1st milestone testing #IFNlambda against #SARS_CoV_2 with no safety issues. We look forward to further analyses with our @CIHR COVID19 grant 3/4
@JGPharmD @drdalidali @IDJClub Agree. And maybe a subQ injection option. Iโll be curious to see the #IFNlambda data. #IDJClub
Great study looking at various cytokines (esp IFNs) in #COVID19 as compared to #influenza. Especially important that greater #IFNlambda โก๏ธ faster viral clearance! #IFNL1trials ongoing... Looking forward Dr. Andreakos' Zoom talk Monday as part of our biweekly #IFNlambda meetings!
Untuned antiviral immunity in COVID-19 revealed by temporal type I/III interferon patterns and flu comparison https://t.co/mtQ6FMtJ1b
#IFNlambda is produced by thymic epithelial cells and regulates MHC I expression! Ifnlr1 KO mice develop autoantibodies later in life too... Still much more to uncover for how type III IFNs regulate immune responses, one of my favorite topics ๐
https://t.co/qmdLvJGqr3
Just realized today would have been my talk at #AAI in Hawaii but I am happy I can still give the talk next week to our weekly #IFNlambda zoom group. If anyone wants to hear an overview of my latest paper and/or want to join in on our discussion let me know- May 18th 11am EST
While it would be nice to celebrate our latest manuscript or have a bit of a break this weekend, instead I get to write a grant in just a few days for #CIHR - #IFNlambda and #COVID19 of course!๐ฉโ๐ป๐คExcited to start a new collaboration either way!
Honored to be a part of this amazing #IFNLambda expert group brought together by @prokuninaolsson to bring awareness to using IFN-lambda 1 in #COVID19 patients! Through zoom and online editing we were able to quickly put this together for @JExpMed https://t.co/C1SoZE8kSd
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