Top Tweets for #IL7R
Tγδ cells.😤screwed.
#TCRcomplex #MHCmolecules #Tαβ #IL2 #Interleukins #Signalling #JAK3kinase #SCID #IL7R #CD132 #CD4 #CD8 #VaccinesKill
Listen Lovelies -- if you are vaccine injured and your T cell count is up shit creek - I hate to be the one to break it to ya mate.... but you might be on borrowed time.
For successful reconstruction of T cell immunity in the vaccine injured, it might be essential that the bone marrow donor and the vaccine injured recipient, match at least one HLA allele for MHC-I and one allele for MHC-II.
The reasons are twofold:
Firstly, we know that T cells are 'positively selected' in the thymus (epithelial cells) CD3 (DN) and not derived from the bone marrow, therefore proper 'positive selection' must occur on the host MHC allotypes.
Secondly, the Antigen-Presenting Cells necessary for T cell activation in the periphery and B lymphocytes, also derive from donor bone marrow, so in order for a donor-derived APC to activate a donor-derived T cell that's been 'positively selected' on the recipient's MHC, both donor and recipient's HLA allotypes must match.
What that means is - you need a twin.
Unless you've got 5 siblings because one in four of you should be a match. But it's long shot for us Westerner's to have big families these days, much less be on talking terms with them all.
So I think the elephant in the room needs addressing and maybe us adults, can put him on the table, that way if anyone wanting to discuss it, they don't feel they have to self censor.
You might end up considering that your only valid treatment option is 'genetic therapy' to reverse engineer this nightmare. Or perhaps there's a monoclonal antibody treatment that'll reactivate your silent pathways.
I got asked about this subject a couple of years ago from one of my favourite followers -- I explained to her that I'll fight to the death to abolish vaccines, I'll do everything in power to stop that evil.... but I'm never going to stop another human being from choosing a treatment or therapy for their own life & their own circumstances.
For the record, I am 100% certain, that every immunogenetic deficiency the mRNA technology will attempt to fix, was caused by vaccines in the first place.
But there's a big difference from injecting vaccines into brand new, beautiful, perfectly healthy, bundles of baby joy, for no reason at all - compared to someone personally choosing a therapy for a sickness, disease or ailment that they are suffering through and want treated. And I think this difference might be lost on a lot of people. Nobody is good with nuance these days.
Anyway that's my 2 cents for now 😊
Figure 1 :
The MHC molecules are glycoproteins encoded in a large cluster of genes located on chromosome 6. They were first identified by their potent effect on the immune response to transplanted tissue.
For that reason, the gene complex was termed the ‘‘major histocompatibility complex.’’ MHC genes (called the H-2 complex in mice)were first recognised in 1937 as a barrier to transplantation in mice.
In humans, these genes are often called human leukocyte antigens (HLA), as they were first discovered through antigenic differences between white blood cells from different individuals.
MHC is the term for the region located on the short arm of chromosome 6p21.31 in humans and it contains more than 200 of our genes. (mice chromosome 17)
Figure 2
Schema of activation of a T cell producing IL-2 when it receives two signals. Panel B: In contrast, a T cell receiving only signal 1 and not signal 2 acquires a state of anergy with no production of IL-2.
Antigen-Independent T Cell Development
T Lymphocytes Develop in the Thymus
#JI_TopRead from @Vera22380790 @IGCiencia | #IL7R drives Early T lineage Progenitor expansion #ReadtheJI #Immunology #TCellDevelopment #IL7 #Interleukin7 #AdaptiveImmunity #TCells https://t.co/rm5nn1x8Y4
Although >40% of malignant pleural #mesothelioma (MPM) cells from patient samples expressed IL-7R, IL-7 had no effect on their signaling
Th effect of IL-7 on survival of MPM patients was different in pleural effusions vs tumours
🔗https://t.co/1FnE6uBwzJ
#IL7R #ImmunoTwitter
@InflamResCen @jldvib @CarlyEWhyte @singhkailash04 Took some beautiful #flowcytometry experiments from @olivertburton to show that #IL2 production was causing downregulation of #IL7R in CD4 T cells, placing a "metabolic tax" on the production of IL2. Another neat negative feedback cycle! 10/17
Took some beautiful #flowcytometry experiments from @olivertburton to show that #IL2 production was causing downregulation of #IL7R in CD4 T cells, placing a "metabolic tax" on the production of IL2. Another neat negative feedback cycle! 10/17
RT @CIR_AACR: An engineered T cell specific for two antigens shows anti-#AML activity. Combining #CD123 recognition and #IL7R activation enhances antitumor activity and T-cell survival in preclinical models. #DualTargeting #Tcells #AntitumorResponses https://t.co/NrL0Op5HNt
An engineered T cell specific for two antigens shows anti-#AML activity. Combining #CD123 recognition and #IL7R activation enhances antitumor activity and T-cell survival in preclinical models. #DualTargeting #Tcells #AntitumorResponses https://t.co/lutO3zYnMw
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