Top Tweets for #IntegratedStressResponse
How is #Proteoglycan #Glycosaminoglycan accumulated in #ThoracicAorticAneurysm?😎
#AortaEd
An overactivation of #HexosamineBiosyntheticPathway-GAG-#IntegratedStressResponse #ERStress PERK eIF2α ATF4 cascade
Impressive evidence 🐭👤#MarfanSyndrome
Inactivating HBP (by 6-diazo-5-oxo-L-norleucine) or ISR (by ISRIB)▶️
⏬Ascending & Abdominal Aortic diameter by 7 days Repair broken elastin fibers & ⏬GAG deposits by 28 d in Fbn1C1049G/+🐭
This also implicates
1) A fascinating feedback-forward loop b/w GAG-ISR
2) A novel pathologic feature - overall upregulation of O-GlcNac
What is the transcriptional machine up GAG biosynthetic genes? In #SmoothMuscleCell?
Give it a read, Aorta aficionado😆
@MMittelbrunn @JorgeOller4 bioRxiv 2024
https://t.co/OWItlIl0Nb
'The integrated stress response in #neurodegenerative diseases'
Maria Astrid Bravo-Jimenez, Shivangi Sharma, Soheila Karimi-Abdolrezaee @KarimiLab @MB_MSResearch @umanitoba #IntegratedStressResponse
https://t.co/OLlDGKAEfu
#ERStress #IntegratedStressResponse #AbdominalAorticAneurysm
Targeted delivery of PERK inhibitor (GSK2656157) to 🐭#AAA using biomimetic nanoclusters
poly(amidoamine)-PLGA nanoparticles coated with platelet membrane
i.v. >100-fold enriched in aortic lesions vs liver/GI/kidney/spleen🤠
Lian-Wang Guo, Shaoqin Gong, Bowen Wang labs @BioactiveMat 2023 @lian_guo @GongShaoqin @NU_JEANSS
https://t.co/hLeoDxMacB
Cholesterol-induced #SmoothMuscleCell phenotytic plasticity
Activation of KLF4 & Acquisition of atherogenic Macrophage-like or Fibroblast-like features are mediated by #IntegratedStressResponse #ERStress #UnfoldedProteinResponse (PERK arm)
Dianna Milewicz lab @atvbahajournals 2021
https://t.co/vsn9iIBMfc
Check out our Research Highlight on recent work from Amy Lee's lab @HarvardCellBio https://t.co/gtgZLeh1bL #IntegratedStressResponse
✏️In October's issue, our editor Dr. Sabrya Carim (@cSabrya) highlights the recent work by
Amy S.Y. Lee & co published by @MolecularCell and reporting that #eIF3d controls #IntegratedStressResponse.
https://t.co/DjfDjUnO2M
https://t.co/chC1y0MxHk
✏️In October's issue, our editor Dr. Sabrya Carim (@cSabrya) highlights the recent work by
Amy S.Y. Lee & co published by @MolecularCell and reporting that #eIF3d controls #IntegratedStressResponse.
https://t.co/DjfDjUnO2M
https://t.co/chC1y0MxHk
Transcript-Proteomics of #PeripheralArteryDisease
29 Ctrl+31 Case
Gastroc biopsies
Discordant mRNA-protein profiles in PAD➡️
⏫#IntegratedStressResponse/#ERStress
⏬#Mitophagy
tRNA aminoacylation in #LimbIschemia?😯
Dr. Luigi Ferrucci lab @CircRes 2023
https://t.co/pbEMcBiBMS
#OpenAccess
A stay of execution: ATF4 regulation and potential outcomes for the integrated stress response
https://t.co/OOG4OH8NW5
@UoDMedicine
Graham Neill @GlennMasson
#ATF4 #IntegratedStressResponse #apoptosis #CellDivision #SynapticPlasticity
A cell-based chemical-genetic screen for amino acid stress response inhibitors reveals torins reverse stress kinase GCN2 signaling #IntegratedStressResponse #mTORC1 @jbiolchem https://t.co/6gOLiZC098
Small-Molecule Drug Reverses #NeuralEffects-of-#Concussion
#ISRIB, a small molecule that blocks the #IntegratedStressResponse,
can reverse the neural and cognitive effects of a concussion in mice weeks after a #BrainInjury has occurred.
https://t.co/gk6iMUlGCy
📢Online today! Activation of the #IntegratedStressResponse is a vulnerability for multidrug-resistant #FBXW7 -deficient cells
By @KP_twitt_llo, @LauSancBurgos & colleagues @CNIOStopCancer
#MultidrugResistance #IntegratedStressResponse #FBXW7
🗞️https://t.co/4pSuoKq6af
Related to the talks this afternoon at #CSHLprotein #heat22 is the Review "Canary in a coal mine: #collidedribosomes as sensors of cellular conditions"
#integratedstressresponse #mRNAsurveillance
https://t.co/yxjA4G4kxN
Online now - a Spotlight from @vinaybulusu @DurgaMahor1 @Pandeyr755 titled "#TCAcycle off, #ATF4 on for metabolic homeostasis".
#succinatedehydrogenase #fumaratehydratase #integratedstressresponse
https://t.co/NmI15q9cmg
🔎Viewpoint🔍
Stress granules: regulators or by-products?
🔗https://t.co/ROnjIdmVEq
🖋️By Daniel Mateju and Jeffrey Chao @ChaoLabFMI @FMIscience
#stressgranules #antiapoptoticsignaling #innateimmuneresponse #integratedstressresponse #mRNAtranslation
📯 Today our perspectives piece was accepted - 30 min after I submitted the last version! 🕺💃
Thanks to @NatureAging
and @MARZeditor
Great job @mderisbourg
and @HartmanMatias_
#aging #longevity #integratedstressresponse
New Atlas: Drug reboots protein production to reverse age-related cognitive decline.
#IntegratedStressResponse
#CognitiveHealth #nootropics
https://t.co/yegaqV6jp4
via @GoogleNews
Great @agingscitalks Symposium today on #Protein quality control: basic #Mechanisms and New Perspectives in the #biology of #aging! Dr. David Ron discussed targeting the #IntegratedStressResponse using #ISRIB and understanding its mechanisms through #elF2B. (1/4)
Inhibiting the #mevalonate pathway with a #statin (common #cholesterol-lowering drugs) preferentially induced the #IntegratedStressResponse and #apoptosis in this multiple myeloma subtype (2/4)
Our paper on how stress induces plasticity in breast cancer by enabling the translation of stem cell associated transcripts is out. #breastcancer #selectivetranslation #integratedstressresponse
https://t.co/Gg1FNbdCOx
eIF2B extends lifespan through inhibition of the #IntegratedStressResponse amazing speaker @MartinD79 not to be missed #aging #lifespan
New week new talks! Today is Martin Denzel @MartinD79, Max Planck Institute for Biology of Ageing, Cologne. eIF2B extends lifespan through inhibition of the integrated stress response. Monday, Apr 27 · 13:00–14:00
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