Joseph Longo

CIHR Postdoctoral Fellow 🇨🇦 studying cancer & immunometabolism @VAInstitute 🇺🇸. Previously @pmcancercentre, @UofT & @McMasterU.

[Joseph Longo @jlongo92]

I’m excited to share our preprint, where we describe a critical fate of glucose in physiologically activated CD8+ T cells. @DrRGJonesLab @VAIMetabolism https://t.co/06Qm0wX08W

[Ilaria Panzeri (she/her) @Bi0lilla]

Excited to share our work from the @PospisilikJ lab, now in #NatureCancer!

#Epigenetic heterogeneity via Trim28, arising early in #development, shapes long-term #cancer risk.

Check it out: https://t.co/CVjjqXHQiQ

[Joseph Longo @jlongo92]

@OwenJ457 @AnnualReviews Congrats Owen!

[Zewen (Owen) Jiang, PhD @OwenJ457]

1/ 🌟 Excited to share our latest review in Annual Review of Pathology: Mechanisms of Disease! @AnnualReviews 🌟

Obesity isn’t just a metabolic disorder—it’s a fundamentally altered immunological state.

Read it here:
https://t.co/xKfpafluy6

[Chaoran Li @ChaoranLiEmory]

Thrilled to share our latest study in @SciImmunology! We reveal the critical role of Srebf2-dependent cholesterol metabolism in the clonal expansion of insulin-sensitizing ST2hi VAT Treg subsets, and how obesity disrupts this process. https://t.co/RchThAsAk4

[Russell Jones @DrRGJonesLab]

Happy to announce our collaboration with @Tcellogic on metabolic features of exhausted T cells is now out in @ScienceMagazine. TL;DR they can't use acetate to fuel their function. Great work by Shixin Ma and Mike Dahabieh. https://t.co/5skqGae52x

[Brandon Oswald @BrandonOswald3]

I am proud to share the @DrRGJonesLab most recent preprint and the bulk of my thesis project. We show that T cells mediate the anti-tumor effects of dietary restriction. @VAInstitute @VAIMetabolism
https://t.co/cmlU5aJVYk

[Stefan Mereiter @SMereiter]

1/
Did you know? Glycans—complex sugar structures—decorate almost every protein processed by the ER/Golgi. These N-glycans coat our cells, playing critical roles in cell interactions and immune processes. 🍬

Curious about how they vary?

Let’s dive in!

[Delgoffe Lab @DelgoffeLab]

I've been on a Twitter moratorium for the last week given the.. news, but I'm happy to announce a new story from our group @NatImmunol describing a metabolic sensitivity of exhausted T cells to lactic acid in tumors! 1/ https://t.co/3xdR54q1AM

[Long Lab @longlabstanford]

Today in @CellCellPress we report a new pathway of ketone metabolism. This BHB shunt generates an orphan family of anorexigenic ketone metabolites that are chemical cousins of exercise-inducible Lac-Phe. Congratulations @mariadolores_mg @Stanford_ChEMH
https://t.co/dGgAzdtGUw

[Joseph Longo @jlongo92]

@isaac_s_harris Congrats, Isaac!!

[Evan Lien @eclien]

New pre-print from the lab! We describe an alternative route for β-hydroxybutyrate metabolism that allows it to bypass the TCA cycle to support fatty acid synthesis in cancer cells. Check it out! 👇
https://t.co/5VVchI08kB

[Eric Taylor @Mitoverse]

Have you ever wondered how mitochondrial and cytosolic pathways for de novo lipogenesis (DNL) interact?

We did!

Published Online today (https://t.co/l05A4qyCx1) and led by first-author @adam_rauckhorst, we traced 13C-labeled lactate/pyruvate, acetate, the ketone acetoacetate, and leucine in several mouse models of disrupted hepatic mitochondrial and cytosolic acetyl-CoA generating pathways.

Surprisingly, deleting the mitochondria citrate carrier (CiC) increased DNL from both exogeneous and leucine-generated acetoacetate. Overall, our findings delineate a mitochondrial-cytosolic DNL substrate supply network that may guide more accurate therapeutic development for MASLD and T2D.

Many thanks to our expert collaborators: No X Ryan Sheldon, now leading metabolomics at the @VAInstitute, who helped start the project and develop the necessary mass spec methods with @adam_rauckhorst; for @StanislawDeja and @Isotopomer for deuterium tracing by NMR and careful contibutions to quantitatively framing our mass spec data; and Tom Vallim of @TarlingVallim for guidance with in vivo gene deletion by AAV CRISPRs.

Please also see the exciting co-published manuscript from @WellenLab and Christian Metallo Labs (https://t.co/Wq1JH6AXZS) showing that bempadoic acid does more than just inhibit ACLY!

@FOEDRC, @UIowaResearch, @UIMolecPhysBio

[Fabio Hecht @fabiohecht]

🚨 Preprint alert! Our new work uncovering that glutathione (GSH) boosts tumor growth by supplying amino acids is now available at @bioRxiv!

Check it out 👇🏼and follow along for the #tweetorial (1/10)

https://t.co/RpyACVbufW

[Evan Lien @eclien]

Excited to share the first research publication from our lab! Lipid availability influences ferroptosis sensitivity in cancer cells by regulating polyunsaturated fatty acid trafficking
https://t.co/Pnp5ML5nWm

[FrezzaLab @FrezzaLab]

Catabolism of extracellular glutathione supplies amino acids to support tumor growth https://t.co/okWA1YNNsO

And a very exciting piece of work from @isaac_s_harris & team!

[bioRxiv Immunology @biorxiv_immuno]

Glucose-dependent glycosphingolipid biosynthesis fuels CD8+ T cell function and tumor control https://t.co/WyU7ZOvxp6 #biorxiv_immuno

[Joseph Longo @jlongo92]

This work was made possible by our outstanding core facilities @VAInstitute and the help of our collaborators. Please pass along any thoughts or feedback you may have!

[Joseph Longo @jlongo92]

I’m excited to share our preprint, where we describe a critical fate of glucose in physiologically activated CD8+ T cells. @DrRGJonesLab @VAIMetabolism https://t.co/06Qm0wX08W

[Joseph Longo @jlongo92]

Taken together, we propose that GSL biosynthesis tethers CD8+ T cell-mediated immune responses to glucose availability, and that targeting GSL metabolism in T cells may be an effective strategy to modulate T cell function.