Top Tweets for #JAKStat
Is #JAKSTAT a friend or foe in #SolidTumors?
This review reveals paradoxical roles, showing how direct inhibition fuels immune exhaustion and proposes system‑level targeting to overcome the impasse. @zzu_china
#GenesAndDiseases: https://t.co/fO5Gua7zEf
New preprint 🔥 showing that blocking JAK1/2 with ruxolitinib boosts food intake, preserves fat, and extends survival in lung cancer–associated cachexia. @eze_dantas https://t.co/n9FER7D3C9
#CancerMetabolism #Cachexia #LungCancer #JAKSTAT
“When one organ is wounded, how does the rest of the body know to protect itself?” We explored exactly this question in our latest preprint 👇
🔗 https://t.co/120fzkqELX
#Preprint #JAKSTAT #Regeneration #Drosophila #ImmuneSignaling #GutHomeostasis
Excited to share our new AI-based platform, PB-scope, for phenotypic screening of P-body morphology. We discovered that the JAK/STAT pathway regulates P-body structure, revealing a previously unknown mechanism! #AI #CellBiology #PBody #JAKSTAT https://t.co/RwIedXTv8i
😷Incluso un Covid leve puede dejar secuelas duraderas.
🧬28 meses después,tu cuerpo aún muestra inflamación y cambios celulares.🔍La ciencia avanza,pero el virus sigue dejando huella.Lee el estudio👉 https://t.co/2HnniVvCq4
#LongCovid #CovidPersistente #JAKSTAT #Salud #Ciencia
#GUTImages from the paper by Shi et al on
"Butyrate-producing Faecalibacterium prausnitzii suppresses natural killer/T-cell lymphoma by dampening the JAK-STAT pathway" via
https://t.co/apGovk3iV3
#JAKSTAT #Microbiota
#GUTImages from the paper by Shi et al on
"Butyrate-producing Faecalibacterium prausnitzii suppresses natural killer/T-cell lymphoma by dampening the JAK-STAT pathway" via
https://t.co/apGovk3iV3
#JAKSTAT #Microbiota
#GUTImages from the paper by Shi et al on
"Butyrate-producing Faecalibacterium prausnitzii suppresses natural killer/T-cell lymphoma by dampening the JAK-STAT pathway" via
https://t.co/apGovk3iV3
#JAKSTAT #Microbiota
Has anyone here with ME/CFS, dysautonomia, or Long Covid, tried a JAK STAT inhibitor medication and found it helpful or hurtful? If yes, which med and what dose and how long were you on it? Thx!
Super collab - #Derm #allergy 🙌 👌Important session from @CouncilEczema informing us all about #JAKStat pathway-mechanisms, safety & RW data - day 2 morning lift off #EAACI2024
Double strike today with our paper in @NatImmunol https://t.co/ZRHylsWj3u and our paper together with T. Deckers lab of the @MaxPerutzLabs+@MedUni_Wien in @embojournal https://t.co/YbjiA8xUlO - a companion published as part of the @FWF_at funded SFB consortium. #JakStat forever!
An amazing 7 year journey now finally materialising! So proud of our whole team! Special thanks to @Nik_Fortelny, who went with me through several highs and lows; M. Müller, T. Decker and @BockLab, and the institutions including the @FWF_at for their support! #JakStat forever!
Full story at @NatImmunol: https://t.co/P92IFUFnId (#OpenAccess). Joint work with Vienna JAK-STAT consortium led by M. Müller (@VetmeduniVienna) & T. Decker (@MaxPerutzLabs). Analysis led by @Nik_fortelny (now PI @PLUS_1622). Experiments led by @MFarlik (now PI at @MedUni_Wien).
Excited to share our latest work with the #JAKSTAT research network led by @richard_moriggl @VetmeduniVienna in @jclinicalinvest! We show that hyperactive #STAT5 mimics TCR signaling in T-ALL, identifying STAT3/5 degraders & ZAP70 inhibitors as a synergistic therapeutic strategy!
@YaleMed student Rachel Jaber Chehayeb presents our work: using explainable AI/ML to id top cytokine features and pathways of pts w/#ICImyocarditis & immunosuppression resistant ICImyocarditis #JAKStat pathway is a top pathway @YaleCardiology @YaleCancer @YaleMed #cardioonc
A newly identified 45-kDa JAK2 variant with an altered kinase domain structure represents a novel mode of JAK2 kinase inhibitor resistance
🔗https://t.co/04cv6zTFkH
#JAKSTAT #Kinase #Ruxolitinib #MyeloproliferativeNeoplasm
Congratulations to Joseph for receiving an @american_heart (AHA) predoctoral fellowship!
@LSUHS @LSUHSResearch @LSUHS_PhD
#virology #JAKSTAT #science #HCMV
#herpesisforever
The #CNS Bernard Sachs #Award is given annually to honor an internationally recognized leader in #neuroscience & #childneurology research. This year’s recipient @Brooks_Kayal_MD @UCDavisHealth has done groundbreaking research in #epilepsy #neurotransmitters #JAKSTAT.
🌤️Our June issue is out ⛱️
🔓https://t.co/hmX7NZvTUR
📘Cover: Highlight on the partnership between our journal and the EACR
🔎Explore Articles on #CancerMetabolism #CancerPolicy #SyntheticBiology #NSCLC #CRCSM #TargetedTherapy #GeneFusion #PP2A #TNBC #PARPi #JAKSTAT #LYLSM
Excited to have helped discover this #autoinflammatory disease w colleagues @UCSDHealth @NHGRI, here @PittRheum, and @ChildrensPgh. Could #jakstat inhibitors be effective for other forms of scleroderma/fibrosis? #immunodeficiency #RareDisease #genetics https://t.co/gQJW952Mlo
Our new @NatImm paper is out today! We found that JAK/STAT-induced bystander activation causes Th9-driven allergic inflammation. Th9 instability is a negative checkpoint on this mechanism that breaks down in allergy, so Th9 cells “mark” responsiveness to JAK inhibitors. A🧵1/10
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