Top Tweets for #Cachexia
ICYMI: What drives metabolic dysfunction and body wasting in cancer #cachexia?
https://t.co/PHjO2GthRb
Here, Pauline Morigny @MorignyPauline Maria Rohm @RohmMaria & team @HelmholtzMunich find high circulating ceramides define cancer cachexia in mice and patients. And targeting ceramide synthesis counteracts mitochondrial dysfunction, impaired energy homeostasis, and muscle atrophy in cachectic mice.
The image: In primary hepatocytes, ceramides interfere with mitochondrial branching and junctions, inducing cachexia-like phenotypes.
#Metabolism #Ceramide
Learn more about how #cancer affects #muscles in this #ArticleinPress, Dietary supplementation with ursolic acid preserves skeletal muscle mass and strength in mouse models of cancer #cachexia (Jeremy B. Ducharme et al. @UF):
https://t.co/TUrKFcqQl1
What drives metabolic dysfunction and body wasting in cancer #cachexia?
https://t.co/PHjO2GthRb
Here, Pauline Morigny @MorignyPauline Maria Rohm @RohmMaria & team @HelmholtzMunich find high circulating ceramides define cancer cachexia in mice and patients. And targeting ceramide synthesis counteracts mitochondrial dysfunction, impaired energy homeostasis, and muscle atrophy in cachectic mice.
The image: In primary hepatocytes, ceramides interfere with mitochondrial branching and junctions, inducing cachexia-like phenotypes.
#Metabolism #Ceramide
Happy to share our latest paper showing that liver-derived #ceramides drive #muscle dysfunction in #cancer #cachexia . Study led by @MorignyPauline at
@helmholtz_diabc
I hope you’ll enjoy reading it !
Link to the paper below 👇
https://t.co/qXNbmIRot9
Associated comment 👇
https://t.co/Zvffbha6uo
#Cachexia is a multifactorial syndrome prevalent in advanced illness.
Guidelines rarely integrate the relational, multidimensional perspective of #palliativecare (PC). Addressing this gap is essential to optimize care.
🔗https://t.co/LBxsRe6UBA
#delphiforum
The 👑 of #cachexia @EdReznik is revealing the deep biological insight from the emperor of all maladies. 🦀
Really exciting work from @EdReznik @MSKCancerCenter revealing deeper biological insight into cancer cachexia, one of the most complex and clinically meaningful paraneoplastic syndromes in oncology.
This is the beginning of deciphering multidimensional molecular and clinical data that may ultimately help define biologically distinct cachexia subtypes and guide future therapeutic strategies.
Our cachexia group is also studying how these processes affect clinical outcomes and quality of life.
@jmsongmd @MichaelMayMD @MarcHilmi @EileenMOReilly #sPARKlab
#psychooncology #immune #cachexia #HBP
@NatPancFdn @PanCAN @letswinpc @MSK_DeptOfMed @CpcrMsk
Our starting point was anatomy, and we wanted to bring it back to the molecular phenotype of the tumor itself. Using single cell data from the POLAR trial led by @CentralParkWMD, we found that Type A patients demonstrated ++inflammatory signaling specifically in tumor cells
A grant from @TheVFoundation will allow Hollings researcher Dr. Denis Guttridge to investigate the inflammatory signals driving #Cachexia in #PancreaticCancer.
Learn more: https://t.co/ejgsyy5pmE
#CancerResearch #Oncology #TranslationalResearch #VFoundation
Handgrip strength-based cachexia index with frailty in cancer survivors: Evidence from health and retirement study https://t.co/a8QTtdDApp @WilliamDale_MD @myCARG #GeriOnc #OlderAdults #OncoAlert #SIOG #YoungSIOG #Elsevier #HandgripStrength #Cachexia
#Frailty
Combined Effect of Sarcopenia and Impaired Respiratory Function on All-Cause Death: A Nationwide Cohort Study
https://t.co/gbiTsVM7Xz
サルコペニアと呼吸機能障害の併存が全死亡に及ぼす影響：全国コホート研究
#physiotherapy #physicaltherapy #musclewasting #cachexia #frailty
AWGC criteria identify a previously unrecognized subgroup (“A-only”) with shorter survival despite similar progression-free survival, suggesting a potential window for early intervention.
https://t.co/1JnPzGX06P
#IARN #RehabNutrition #Cachexia
cAMP and mitochondrial dysfunction in cancer cachexia: Trends in Molecular Medicine https://t.co/9WSauNJcFh Time to try #apremilast or #roflumilast in #cancer #cachexia ?
Dympna Waldron, et al. had their recent publication in Hospice & #Palliative #Medicine International Journal, titled Overriding policy on intravenous opioids versus subcutaneous route on rare occasions...view more
https://t.co/gADvP73FKv
#plasma #Cachexia #oncology #Oradispersa
AWGC-based cachexia risk classification in dysphagia patients predicted mortality (~8× higher in cachexia) and was associated with sarcopenia and malnutrition. Early risk identification may guide rehabilitation nutrition.
https://t.co/l0dE6wLLLF
#IARN #RehabNutrition #Cachexia
One disease classically associated with #cachexia is #rheumatoid #arthritis (RA), affecting about two-thirds of patients. Two forms of cachexia occur in RA: rheumatoid cachexia with normal BMI (low muscle mass and increased fat mass) and classic cachexia with low BMI (low muscle mass and low fat mass).
Classic cachexia is rarely seen in RA but is associated with severe systemic inflammation, increased cardiovascular disease (CVD) risk and poor RA outcome. Rheumatoid cachexia has features of both classic cachexia and obesity and might represent the ‘worst of both worlds’ with respect to cardiovascular outcomes.
There is a lack of agreed diagnostic criteria for rheumatoid cachexia and this hampers research into the prevalence and importance of this condition. In addition, it is underdiagnosed in routine clinical practice, since unlike other cachexias, total weight may not decrease drastically, but body composition changes: muscle is lost and fat increases, especially in early stages (sarcopenic obesity).
Treatment with methotrexate or biologic DMARDs like tumor necrosis factor inhibitors has not yet been shown to reverse rheumatoid cachexia, although exercise therapy is likely to be beneficial.
Which disease can lead to such cachexia?
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