Top Tweets for #KL6
Phenotypic characterization and biomarker assessment in rheumatoid arthritis-associated interstitial lung disease
#Rheumatology #RheumatoidArthritis #InterstitialLungDisease #Biomarkers #MUC5B #KL6 #Telomeres
*From: Sullivan, D.I., Ascherman, D.P. Rheumatoid Arthritis-Associated Interstitial Lung Disease (RA-ILD): Update on Prevalence, Risk Factors, Pathogenesis, and Therapy. Curr Rheumatol Rep 26, 431–449 (2024).
🔗https://t.co/qAm1LSeLSp
🔥🔥Incorporating #KL6 and #MMP7 as routine #biomarkers for #RA-#ILD
📊 Results
Key Findings:
1⃣ KL-6 and hSP-D baseline levels significantly predicted ILD progression (HRs 1.37 and 1.51 per SD increase, respectively).
2⃣ Annual changes in KL-6 and MMP7 were strongly linked to progression (∆KL-6 HR 2.33, ∆MMP7 HR 1.69).
3⃣ hSP-D annual change showed no significant association.
Statistics:
▪️Patients in the highest KL-6 quartile (Q4) had the worst progression-free survival (HR 2.95 vs. Q1).
▪️Confidence intervals were narrow, indicating precision in estimates.
💪Strengths:
🔹Standardized measures (e.g., KL-6 via immunoturbidimetric assay).
🔹Rigorous follow-up and consistent assessment via CT scans and PFTs.
⚠️Limitations:
🔻Small sample size and single-country cohort (Korean population) limit generalizability.
🔻No explicit discussion of missing data or attrition rates.
🔻Biomarker variability or laboratory errors could influence findings.
🔑 Conclusions
✅KL-6 and MMP7 are promising biomarkers for predicting RA-ILD progression, particularly KL-6 for its baseline and dynamic changes.
✅These biomarkers provide actionable insights for risk stratification and monitoring in RA-ILD patients.
💡 Implications
Clinical Use: Serial KL-6 measurements should be incorporated into routine RA-ILD monitoring to guide treatment decisions.
Future Research: Multicenter studies with diverse populations are needed to confirm findings. Mechanistic studies on biomarker roles are also recommended.
⏩https://t.co/ulSbPLHinj
Dr. Rahul Banerjee with an outstanding keynote lecture #KL6 introducing his work on Covalent Organic Framework Nanotubes 😍 #EUROMOF2023
ഓഫീസിൽ ഇടുക്കിയിൽ നിന്നുള്ള പിള്ളേരുണ്ടെങ്കിൽ ഇങ്ങനെ ചില ഗുണങ്ങൾ ഒക്കെ ഉണ്ട്
#kl6
@lung_fibrosis 広島大 河野修興先生が発見された本邦発のbiomarkerですね。免疫チェックポイント阻害薬全盛の昨今では測定される機会が非常に増えておりますので、大事ですね(最近ではCOVID-19でさらに↑)。
命名には娘さんのお名前も関連しているというところに心くすぐられます。
#KL6
Maruti Suzuki XL6 Officially Launched in India: Everything you want to know
https://t.co/2x1WBMCbyK
#KL6 #MarutiSuzukiXL6 @NexaExperience
Horrible, Feo, Espantoso, Ridículo, Penoso, Trágico, Escandaloso, monstruosamente malo lo del líder de nuestro torneo ante el @ClubSantos
Se comió 6 en la #Concachampions el #Marathon
#kl6-2
Don’t work 8hrs for a company then go home and not work on your own goals. You’re not tired, you’re uninspired. #KL6 #ThisIsAmerica #Klassix #StayTrue #InMyFeelingsChallenge
Paloma Millán ready to present our data about #KL6 in CTD-ILD at #WASOG2018
@HospitalSantPau
@IIBSantPau
@reuma_santpau
@IvanCastellvi presenting our data about #KL6 and #systemicsclerosis at #SER18 Could it be a useful marker of early vascular involvement?
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