#kl6 - Twitter Hashtag

almost 2 years ago

Phenotypic characterization and biomarker assessment in rheumatoid arthritis-associated interstitial lung disease #Rheumatology #RheumatoidArthritis #InterstitialLungDisease #Biomarkers #MUC5B #KL6 #Telomeres *From: Sullivan, D.I., Ascherman, D.P. Rheumatoid Arthritis-Associated Interstitial Lung Disease (RA-ILD): Update on Prevalence, Risk Factors, Pathogenesis, and Therapy. Curr Rheumatol Rep 26, 431–449 (2024). 🔗https://t.co/qAm1LSeLSp

alb_giraldo's tweet photo. Phenotypic characterization and biomarker assessment in rheumatoid arthritis-associated interstitial lung disease

#Rheumatology #RheumatoidArthritis #InterstitialLungDisease #Biomarkers #MUC5B #KL6 #Telomeres

*From: Sullivan, D.I., Ascherman, D.P. Rheumatoid Arthritis-Associated Interstitial Lung Disease (RA-ILD): Update on Prevalence, Risk Factors, Pathogenesis, and Therapy. Curr Rheumatol Rep 26, 431–449 (2024).
🔗https://t.co/qAm1LSeLSp

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Alfredo Pachas @AlfredoPachasMD

almost 2 years ago

🔥🔥Incorporating #KL6 and #MMP7 as routine #biomarkers for #RA-#ILD 📊 Results Key Findings: 1⃣ KL-6 and hSP-D baseline levels significantly predicted ILD progression (HRs 1.37 and 1.51 per SD increase, respectively). 2⃣ Annual changes in KL-6 and MMP7 were strongly linked to progression (∆KL-6 HR 2.33, ∆MMP7 HR 1.69). 3⃣ hSP-D annual change showed no significant association. Statistics: ▪️Patients in the highest KL-6 quartile (Q4) had the worst progression-free survival (HR 2.95 vs. Q1). ▪️Confidence intervals were narrow, indicating precision in estimates. 💪Strengths: 🔹Standardized measures (e.g., KL-6 via immunoturbidimetric assay). 🔹Rigorous follow-up and consistent assessment via CT scans and PFTs. ⚠️Limitations: 🔻Small sample size and single-country cohort (Korean population) limit generalizability. 🔻No explicit discussion of missing data or attrition rates. 🔻Biomarker variability or laboratory errors could influence findings. 🔑 Conclusions ✅KL-6 and MMP7 are promising biomarkers for predicting RA-ILD progression, particularly KL-6 for its baseline and dynamic changes. ✅These biomarkers provide actionable insights for risk stratification and monitoring in RA-ILD patients. 💡 Implications Clinical Use: Serial KL-6 measurements should be incorporated into routine RA-ILD monitoring to guide treatment decisions. Future Research: Multicenter studies with diverse populations are needed to confirm findings. Mechanistic studies on biomarker roles are also recommended. ⏩https://t.co/ulSbPLHinj

AlfredoPachasMD's tweet photo. 🔥🔥Incorporating #KL6 and #MMP7 as routine #biomarkers for #RA-#ILD

📊 Results
Key Findings:
1⃣ KL-6 and hSP-D baseline levels significantly predicted ILD progression (HRs 1.37 and 1.51 per SD increase, respectively).
2⃣ Annual changes in KL-6 and MMP7 were strongly linked to progression (∆KL-6 HR 2.33, ∆MMP7 HR 1.69).
3⃣ hSP-D annual change showed no significant association.

Statistics:
▪️Patients in the highest KL-6 quartile (Q4) had the worst progression-free survival (HR 2.95 vs. Q1).
▪️Confidence intervals were narrow, indicating precision in estimates.

💪Strengths:
🔹Standardized measures (e.g., KL-6 via immunoturbidimetric assay).
🔹Rigorous follow-up and consistent assessment via CT scans and PFTs.

⚠️Limitations:
🔻Small sample size and single-country cohort (Korean population) limit generalizability.
🔻No explicit discussion of missing data or attrition rates.
🔻Biomarker variability or laboratory errors could influence findings.

🔑 Conclusions
✅KL-6 and MMP7 are promising biomarkers for predicting RA-ILD progression, particularly KL-6 for its baseline and dynamic changes.

✅These biomarkers provide actionable insights for risk stratification and monitoring in RA-ILD patients.

💡 Implications
Clinical Use: Serial KL-6 measurements should be incorporated into routine RA-ILD monitoring to guide treatment decisions.

Future Research: Multicenter studies with diverse populations are needed to confirm findings. Mechanistic studies on biomarker roles are also recommended.

⏩https://t.co/ulSbPLHinj

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ビルくんのmama @RiePokegoTL45

over 2 years ago

今日は🏥大学病院で定期診察の日でした。肺の数値(KL-6)が前回(2023年11月9日)は713でしたが、今日は764でした。横ばいの数値だったので安心しました。 #全身性強皮症 #間質性肺炎 #KL6

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EuroMOF 2023 @Euromof2023

almost 3 years ago

Dr. Rahul Banerjee with an outstanding keynote lecture #KL6 introducing his work on Covalent Organic Framework Nanotubes 😍 #EUROMOF2023

Euromof2023's tweet photo. Dr. Rahul Banerjee with an outstanding keynote lecture #KL6 introducing his work on Covalent Organic Framework Nanotubes 😍 #EUROMOF2023 https://t.co/IphhVerTvh

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まみ @lal_mami

about 3 years ago

今日は明日の受診の前の採血。来れる人は受診前日の午後に来てくれたら待ち時間がないよ〜って事で。お昼食べてから行くんだけど、がっつりボリューム系のランチは避けた方が良いかなぁ🧐 #皮膚筋炎 #採血 #KL6 #下がってて

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Struggling Rebel @AlIlluminatti

about 4 years ago

ഓഫീസിൽ ഇടുക്കിയിൽ നിന്നുള്ള പിള്ളേരുണ്ടെങ്കിൽ ഇങ്ങനെ ചില ഗുണങ്ങൾ ഒക്കെ ഉണ്ട് #kl6

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TNT @DrChamallo

almost 5 years ago

Quand on tient la version papier, c’est que c’est concret #Covid_19 #IL6 #KL6

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バン@内科医のジレンマ @lostphysicianYB

about 5 years ago

@lung_fibrosis 広島大　河野修興先生が発見された本邦発のbiomarkerですね。免疫チェックポイント阻害薬全盛の昨今では測定される機会が非常に増えておりますので、大事ですね(最近ではCOVID-19でさらに↑)。命名には娘さんのお名前も関連しているというところに心くすぐられます。 #KL6

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呼吸器内科医とっと

@lung_fibrosis

about 5 years ago

はてなブログを更新しました！ #間質性肺炎 #KL6 間質性肺炎で調べる血液検査：KL-6 - 呼吸器専門医の間質性肺炎ブログ https://t.co/6D0P6vGpNy

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いなかの薬剤師 @vK1ypqSCGldQbs3

about 6 years ago

#間質性肺炎と #癌について～ #KL6 の基準値や臨床的意義～ | いなかの薬剤師 https://t.co/pdHigm1kyK @vK1ypqSCGldQbs3より意外と抜けてませんか？難しい・・・ #拡散希望 #リツイート希望 #肺癌

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Check on Road Price @CRP_India

about 7 years ago

Maruti Suzuki XL6 Officially Launched in India: Everything you want to know https://t.co/2x1WBMCbyK #KL6 #MarutiSuzukiXL6 @NexaExperience

CRP_India's tweet photo. Maruti Suzuki XL6 Officially Launched in India: Everything you want to know

https://t.co/2x1WBMCbyK

#KL6 #MarutiSuzukiXL6 @NexaExperience https://t.co/xGyf89R9Q0

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Kike Lanza @kikelanza10

over 7 years ago

Horrible, Feo, Espantoso, Ridículo, Penoso, Trágico, Escandaloso, monstruosamente malo lo del líder de nuestro torneo ante el @ClubSantos Se comió 6 en la #Concachampions el #Marathon #kl6-2

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Albin Mathew @Albinrichu

almost 8 years ago · Kerala

#കട്ടപ്പനക്കാരൻ #insta #kl6 #ktpna @ Kattapana, India https://t.co/PXb3Hdbvg2

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Albin Mathew @Albinrichu

almost 8 years ago · Kerala

#കട്ടപ്പനക്കാരൻ #KL6 @ Kattapana, India https://t.co/IsGKYRL3t3

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JK @jayce2fast

about 8 years ago

Don’t work 8hrs for a company then go home and not work on your own goals. You’re not tired, you’re uninspired. #KL6 #ThisIsAmerica #Klassix #StayTrue #InMyFeelingsChallenge

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