Top Tweets for #LyTACs
Read the Editorial: Induced proximity in biology and therapeutics, learn more about #PROTACs #RNATACs #Therapeutics #Velcrins #Wnt #KEAP1 #MolecularGlues #Bifunctional #PPI #Epigenetics #glycoRNA #photocatalytic #TPD #LyTACs https://t.co/jXQ0dF7JHX
Excited to see this in print! I’m grateful for the incredible support and mentoring from @CarolynBertozzi and @StevenMBanik as well as my amazing collaborators @CaitlynBioE @riley_nm1 and Jennifer Cochran! #LYTACs
In a new paper, @Green_Ahn, @CarolynBertozzi and colleagues expand LYTACs-based targeted protein degradation methods to a new ligand-receptor system. Free to read: https://t.co/RTexeaA6iq. https://t.co/C502a8tKKc
Congrats to @Green_Ahn for driving this work! Establishes tissue specific #LYTACs, as well a whole range of new degraders. Great to dig into the lysosomal health effects of LYTACs and the potential for PK modulation in vivo, and set the stage for new mechanistic questions!
‼️Phenomenal‼️ talk from @CarolynBertozzi today for the @umichmedicine #Biochemistry series (work by @StevenMBanik, @Green_Ahn). If you haven't heard of #LYTACs, gotta check these out 🤯 Even more impactful hearing "in person"; 1st virtual talk to hold my attention for an hour 👏🏼
#LYTACs Ingredients: 1. Antibody 2. Target of the antibody 3. Mannose tail 4. Mannose receptors 5. lysosomes. Stick 3 to 1, mix with 2 and 4 and watch them travel to 5 all together. Voila!
How lucky are we to have access to these exciting seminars from the #danafarber #dfci this time featuring #CarolynBertozzi?! There a few benefits to #COVID19, but virtual meetings are def the upside, esp. for us #downunder! Check out her talk on #LYTACs! https://t.co/vp9hkSmcZC
.@StevenMBanik, co-director
@CarolynBertozzi, and team develop molecules called #LYTACs for targeting and degrading proteins that help #AlzheimersDisease and #cancer evade immune regulation.
More on this excellent study: https://t.co/eaM7KQWorU
Lysosome-targeting chimaeras #lytacs for degradation of extracellular proteins by @CarolynBertozzi @StevenMBanik
https://t.co/HlSxZUKSWA
@StevenMBanik might be a better scientist but I’m definitely a better (mouse) surgeon. Huge congrats to Steven and @CarolynBertozzi on their new paper out in @nature on #LYTACs https://t.co/8URkVGWbhg
Shout out to my fellow Yale Chemical Biology colleagues on their new #targetedproteindegradation approach- all small molecule #LYTACs! @DASpiegel256 https://t.co/xyjHFrNpjX
Happy to see this in print! Great team with @KayvonPedram, Simon Wisnovsky, @Green_Ahn, and @riley_nm1! Stay tuned for the next big story from @Green_Ahn (soon!). Loads of unanswered questions on the biology side and unique synthetic conjugates remain to explore #LYTACs!
Congratulations @CarolynBertozzi and welcome to the #targetedproteindegradation field! #LYTACs are a great complement to #PROTACs to address extracellular proteins. Wishing you and Lycia much success.
Targeting proteins that #PROTACs can’t !
#LYTACs #LysosomeTargetingChimeras #ProteinDegradation #TPD #undruggable #NextGenerationPROTACs
Congrats @CarolynBertozzi for launching Lycia Therapeutics with $50M to tackle protein degradation with LYTACS!! https://t.co/szpahR1uPY
Great talk today @MIT @ChemistryMIT by @StevenMBanik from @Stanford. With @CarolynBertozzi he developed
#LYTACs as "next generation" #PROTACs for the targeted degradation of extracellular and membrane proteins.
https://t.co/7bfIx7GRTK
How to extend the concept of targeted degradation by #PROTACs to extracellular targets? After #LYTACs by @CarolynBertozzi now introducing #ENDTACs courtesy of @CraigMCrews: proof-of-concept by equipping a CXCR7 agonist with a HaloTag warhead: @ACSCentSci https://t.co/5rJ4z6Oa2X
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