Top Tweets for #MrDM
This highlights why we shouldn't automatically accept #international decisions without question. We need to reflect critically, consider scientific research emerging from #India, and adopt an India-focused perspective—esp. since most "#MRDM" cases have been reported from India.
Nice article by @docanoopmisra, @AskDrShashank and @DrAmbrishMithal explaining why more research is needed before we accept Type 5 diabetes as a new entity. Our own data suggests that it was just one end of the spectrum of type 2 diabetes.
To read the article, click here: https://t.co/HWSI7HT0Qw.
Malnutrition-related #diabetes mellitus (MRDM) was once seen as a distinct type linked to #undernutrition and low #BMI. There is paucity of robust data, and calling #MRDM “Type 5 diabetes” isn’t justified today. PDF: email anoopmisra@gmail,com
@AskDrShashank @DrAmbrishMithal
Malnutrition related diabetes mellitus #MRDM is a poorly defined entity. It was included in the classification in the 1980s and then withdrawn. No new data has emerged that merits it's re- emergence.
To call it type 5 when type 3 and type 4 are vaguely classified and are not in common use, even among experts seems strange.
Our opinion on this subject - thanks- lead author @docanoopmisra, coauthor @AskDrShashank
#diabetes #type5diabetes.
"Type 5 diabetes” lacks sufficient modern evidence, biological clarity, and practical utility- concluds new review
@docanoopmisra @AskDrShashank
@DrAmbrishMithal @singhak_endo
@kamleshkhunti @IndiaESI @banshisaboo
@IntDiabetesFed
@Rssdi_official @scottisaacsmd @DanielJDrucker @deepduttaendo
@drsreenivasa
Malnutrition-Related Diabetes Mellitus (MRDM) by Misra, Joshi, and Mithal (2025):
🩺 Clinical Pearls: Malnutrition-Related Diabetes Mellitus (MRDM)
🧠 Historical Context
📌 First described in the 1950s in tropical developing regions as a distinct diabetes form in chronically undernourished individuals.
🏥 Characterized by:
• Low BMI
• Onset in youth or early adulthood
• High insulin requirements
• Ketosis resistance despite insulinopenia
🧾 WHO acknowledged MRDM in 1985 but withdrew it from classification in 1999 due to poor evidence and diagnostic inconsistency.
📉 Diagnostic Limitations
❌ No specific biomarkers—diagnosis mostly by exclusion.
⚖️ Low BMI alone is not a reliable indicator of undernutrition, especially in constitutionally lean populations like in South Asia.
🔄 Clinical features significantly overlap with lean type 2 diabetes, atypical type 1 diabetes, and pancreatic diabetes.
🧬 Pathophysiological Uncertainty
🧪 Mechanisms behind MRDM remain unclear—insulin secretory defects have been suggested but not confirmed in robust, modern studies.
📉 No proven distinct molecular or autoimmune pathway.
🧑🔬 A 2022 study showed some insulin deficiency, but it had serious limitations (e.g., all male sample, no follow-up).
🌍 Epidemiological Shift
🍛 Global nutrition patterns have changed—undernutrition has declined, while obesity and type 2 diabetes have surged.
🔄 Malnutrition is now being seen more as a consequence of diabetes (due to glucose wasting, catabolism, GI dysfunction) rather than a cause.
🚫 “Type 5 Diabetes” Classification: Not Justified
❓ Type 3 (e.g., Alzheimer’s-linked) and Type 4 (age-related insulin resistance) lack formal status—Type 5 is premature.
⚠️ Introducing “Type 5” could create confusion without improving clinical outcomes or therapeutic guidance.
📚 Reclassification should be based on modern pathophysiology, not outdated or loosely defined phenotypes.
🧭 Clinical & Research Implications
🧠 Be cautious in labeling lean, insulin-requiring patients as MRDM without autoimmune markers or pancreatic damage.
🧪 Need for prospective, large-scale studies with genetic, metabolic, and immunological profiling.
🌐 Future diabetes classification should focus on precision medicine, not anthropometry or historical constructs.
🔚 Bottom Line
Malnutrition-Related Diabetes Mellitus is not a clearly distinct entity in today’s metabolic landscape. The proposal to classify it as “Type 5 diabetes” lacks sufficient modern evidence, biological clarity, and practical utility.
https://t.co/29ewdoiwDA
@francishylton & I very excited to announce that we #IncognitoDJs open for @BlueLabBeats🔥🔥🔥 Can't wait to meet them all @NAO_WORLDWIDE @______mmk______ @MaoSone1 #AkihaNakajima @bluenote_place 🔗 https://t.co/uINOju3U0U #NKOK #MrDM #opening #bluenote #jeanpaulmaunick
05.10.19
Officially OMPT 🎓🎉
Master in Riabilitazione dei Disordini Muscoloscheletrici
#physiotherapy #ompt #mrdm #sportsphysio #ebp
Judasgedrag is het van zowel instellingsbesturen als van #MRDM
Gebeurt nu voor de 3e keer... #DIS #ROM #MRDM
@GGZNEDERLAND en @PatientenNL doen niks
MIJN expliciete toestemming via MIJN behandelaar is vereist voor doorlevering van MIJN medische data
https://t.co/brQ3C0wF4O
"Legaal?
Het bedrijf #MRDM stelt dat alles volkomen legaal gebeurt. In haar persbericht staat dat het #zorgdata verwerkt in opdracht van de partij die #wettelijk_verantwoordelijk is voor die #data, met een vooraf afgestemd #doel. >
Wegduikende Autoriteit Persoonsgegevens @toezicht_AP faciliteert weer massale overdracht van medische data. Handhaaft niet bij hergebruik bijzondere persoonsgegevens zonder toestemming van de patiënt. #DIS, #ROM, MRDM, het maakt niet uit. @KNMG @ADnl @nrc https://t.co/QC3BzEVdOa
Hergebruik v #medische #gegevens vr #benchmarkingen en #onderzoek (dat #MRDM doet) is discutabel. t is ook n fluitje v n cent om de gepseudonimiseerde data naar n persoon te herleiden
#MedicalData honderdduizenden patiënten in stilte naar Google verhuisd https://t.co/PPlP6m25Sg
Vandaag #AD #Datamacht #Google #MRDM:
https://t.co/IVIS5GxxRh .Mijn bijdrage: "Je kunt met Google samenwerken, maar het is een partij die je goed in de klauwen moet houden, controleren, kritisch volgen. Het zou goed zijn als de @#AutoriteitPersoonsgegevens
#onafhankelijk toetst
C’est Officiel/it’s Official #mrdm #rollerderby #montreal #rollerderby #mrda #rollerskating #skating #rollerskate #roller #instagood #skates #derby #athlete #rollerblade #fitness #instagram #quadskates #rollerderbygirls #rollerderbyguys#sport #skater @m… https://t.co/DuulyiTWH8
Estás en Bahía Blanca? Este fin de semana pasa a visitarnos por el Encuentro Nacional de Juegos de Mesa!
#witty #panzadewitty #geekout #mrdm #juegosdemesa https://t.co/DWoNI8HVsx
நாட்டின் சிறந்த பொறியியல் கல்வி நிறுவனங்களுக்கான பட்டியலில் ஐஐடி சென்னை முதலிடம்: மத்திய மனிதவள மேம்பாட்டுத்துறை அமைச்சகம் தகவல்
#MHRD #MRDM #IIT #chennaiiit #IISC #AnnaUniversity @HRDMinistry
المخضرم #ماكسي_لوبيز يسجل هدفين في مرمى #سمبدوريا ويساهم في فوز #أودينيزي الكبير برباعية نظيفة.
#AraArgFL #MrdM
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