#NeuralProgenitorCell - Twitter Hashtag

over 1 year ago

#TransposableElement #SETDB1 SETDB1-mediated H3K9me3 deposition repress transcription of evolutionary young, full-length LINE-1 retrotransposons (human-specific L1HS & hominoid-specific L1PA2/3) in👤#NeuralProgenitorCell Sai2 No effect on proliferation, neural identity, stemness in 10 days post-CRISPR KO of SETDB1 Any exaggerated responses to inflammatory or genotoxic stress?😁 SETDB1-H3K9me3 formation on L1 elements is independent of KAP1 or HUSH🤓 @KarlssonOfelia @JakobssonLab bioRxiv 2025 https://t.co/5PgerWhRvB

HaoYin20's tweet photo. #TransposableElement #SETDB1

SETDB1-mediated H3K9me3 deposition repress transcription of evolutionary young, full-length LINE-1 retrotransposons (human-specific L1HS & hominoid-specific L1PA2/3) in👤#NeuralProgenitorCell Sai2

No effect on proliferation, neural identity, stemness in 10 days post-CRISPR KO of SETDB1
Any exaggerated responses to inflammatory or genotoxic stress?😁

SETDB1-H3K9me3 formation on L1 elements is independent of KAP1 or HUSH🤓

@KarlssonOfelia @JakobssonLab bioRxiv 2025
https://t.co/5PgerWhRvB

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Hao Yin

@HaoYin20

over 1 year ago

Optimize the time window for cell therapy for #Stroke Photothrombosis Rag2-/-🐭 hiPSC-#NeuralProgenitorCell intracerebral injection 7 days (vs 1 d) post injury➡️ ⏫NPC proliferation ~20-fold⏫survival by 7-wk dpi ↔️neuron vs astrocyte differentiation Any functional benefits?😁 @CTackenberg @rust_ruslan bioRxiv 2025 https://t.co/xtu7lMPCKG

HaoYin20's tweet photo. Optimize the time window for cell therapy for #Stroke

Photothrombosis
Rag2-/-🐭
hiPSC-#NeuralProgenitorCell
intracerebral injection

7 days (vs 1 d) post injury➡️
⏫NPC proliferation
~20-fold⏫survival by 7-wk dpi
↔️neuron vs astrocyte differentiation

Any functional benefits?😁

@CTackenberg @rust_ruslan bioRxiv 2025
https://t.co/xtu7lMPCKG

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Hao Yin

@HaoYin20

almost 2 years ago

Modeling #AlzherimersDisease Vasculopathy & Amyloidopathy in #NeuroVascularUnitOnAChip #BBB Primary #EndothelialCell #Pericyte #Astrocyte in Fibrin gel Immortalized #NeuralProgenitorCell-derived Neuron + Astrocyte in Matrigel -/+ Familial AD mutations (APPSL, PSEN1ΔE9) PDMS #Microfluidics Adding neural compartment to tricellular BBB ⏬permeability by ~50% FAD neural cells▶️ 1⃣Vessel: ⏬diameter ⏫length density ⏫branching ⏬Pericyte coverage ⏫permeability (3 & 40 kDa at day 30) 2⃣Amyloidβ: ⏫in both neural & vascular compartments, preceding permeability increase; ⏫sarkosyl-soluble & -insoluble Aβ42 @georgios_pavlou @PramottonFranci @mejorfi @RudyTanzi @kamm_lab @Biomaterials_ 2024 https://t.co/vUnbJ0tr0j

HaoYin20's tweet photo. Modeling #AlzherimersDisease Vasculopathy & Amyloidopathy in #NeuroVascularUnitOnAChip

#BBB Primary #EndothelialCell #Pericyte #Astrocyte in Fibrin gel

Immortalized #NeuralProgenitorCell-derived Neuron + Astrocyte in Matrigel
-/+ Familial AD mutations (APPSL, PSEN1ΔE9)

PDMS #Microfluidics

Adding neural compartment to tricellular BBB ⏬permeability by ~50%

FAD neural cells▶️
1⃣Vessel: ⏬diameter ⏫length density ⏫branching ⏬Pericyte coverage ⏫permeability (3 & 40 kDa at day 30)
2⃣Amyloidβ: ⏫in both neural & vascular compartments, preceding permeability increase; ⏫sarkosyl-soluble & -insoluble Aβ42

@georgios_pavlou @PramottonFranci @mejorfi @RudyTanzi @kamm_lab @Biomaterials_ 2024
https://t.co/vUnbJ0tr0j

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Pediatrics Med J @pediatricsresj

over 7 years ago

Modeling human pregnancy-associated developmental neurotoxicity in vitro using pluripotent stem cell-derived neurons and astrocytes Read More: https://t.co/4LOmd8ObiC #Developmentalneurotoxicity #Pluripotentstemcell #Highthroughputscreening #Neuralprogenitorcell

pediatricsresj's tweet photo. Modeling human pregnancy-associated developmental neurotoxicity in vitro using pluripotent stem cell-derived neurons and astrocytes
Read More: https://t.co/4LOmd8ObiC
#Developmentalneurotoxicity #Pluripotentstemcell #Highthroughputscreening #Neuralprogenitorcell https://t.co/sHRqVZTtwW

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J SysBio Proteome @Sysbio123

about 8 years ago

#Neuroproteomics in #stemcell #differentiation #Proteomeprofiling #Neuralstemcell #Neuralprogenitorcell

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