Top Tweets for #ORF8
A hidden viral protein may be one of the key drivers of severe COVID-19 lung damage.
➡️ Researchers found that #ORF8, an accessory protein secreted by SARS-CoV-2, can “reprogram” lung macrophages, making them more susceptible to infection and triggering pyroptosis—a highly inflammatory form of cell death. 1/
whenever #Mitochondria comes up I always wonder why no one talks about how they're inherited from mum... seems important to me if they're altered during infection, cos, you know, HIV does similar... #Orf8 #Orf10 if expressed
Health Rising: “The Mitochondria in Long COVID Pt. I: Are Core Problems Being Uncovered?”
“..Nath believes this shift plays a central role in ME/CFS.”
https://t.co/7buIomsPlL
Positive selection underlies repeated knockout of ORF8 in SARS-CoV-2 evolution https://t.co/JBvdTT7bl0
Based on the #seroprevalence of #ORF8 antigen antibodies relative to the no. of reported cases at different times, @CUHKMedicine estimated that ~2.5 million people in HK were infected with #COVID during the #Omicron wave. Among them, one in two were unrecognised. https://t.co/2HBPQ0fbjY
📖@EIDjournal: https://t.co/nKcyTlaOP3
SARS-CoV-2’s accessory protein #ORF8 modulates lung inflammation and clinical disease progression!
The ORF8 protein of SARS-CoV-2 is the most divergent accessory protein from SARS-CoV-1, with the proteins only possessing 40% amino acid identity. 1/
The enigma of ORF8 gene of SARS2!
A recent tweetorial by @LongDesertTrain has rekindled my interest in this accessory protein of SARS2.
During the early stages of the Covid pandemic, there was a lot of speculation on the exact role of ORF8 gene. 1/
https://t.co/TKvY3XgBWK
ORF8 out of the box was/is the primary weapon system of SARS-CoV-2 as we illustrated here in early 2020. This below from Topol is more elucidation on the severity factor caused by ORF8.
#SARSCoV2 is missing a piece and it doesn't even care
A quick tweetorial from @PeacockFlu
H/T @siamosolocani @LongDesertTrain
#ORF8 #AccessoryProtein #COVID19
https://t.co/ztqzjZWunx
Studie: #SARSCoV2 greift in die Epigenetik ein
Das pandemische #Coronavirus greift in die Verpackung der #DNA ein und verhindert so, dass die Zelle Immungene korrekt abliest #ORF8 #H3
https://t.co/atcQ5FAM9M
https://t.co/pB0ZFD7N8W
Fresh from the press: SARS-CoV-2 #ORF8 encodes for a protein that distrupts host epigenetic regulation via histone mimicry
https://t.co/QgRnX0w4Zj
SARS-CoV-2 ORF8 protein binds to dendritic cells and induces a hyper-inflammatory cytokine storm https://t.co/aC7zxfYPXR #Cytokine #SpikeProtein #SARSCoV2 #Coronavirus #Disease #COVID #ORF8 #CytokineStorm @biorxivpreprint @UniCologne @UManitoba
SARS-CoV-2 variants are not evolving to escape from T cell-mediated immunity https://t.co/3yzgC9kOcx #TCell #Immunity #SARSCoV2 #Coronavirus #Disease #COVID #ORF8 @biorxivpreprint @YaleMed @HHMINEWS @Yale
SARS-CoV-2 & ORF8
a very nice summary of a very interesting publication
30kb CoV2 payload consists of 29 proteins: 16x nonstructural, 4x structural & 9 accessory (incl. ORF8)
ORF8?
flooded into bloodstream by infected cells & directly involved with pathogenic cause of covid-19
Cannabidiol may improve innate immune response against SARS-CoV-2 https://t.co/kVSJrFMaJ7 #Cannabidiol #CBDOil #ImmuneResponse #SARSCoV2 #Coronavirus #COVID #ORF8 #ORF10 #Mprotein @UWaterloo @biorxivpreprint
“This sub-lineage harbors extra mutations within the nucleoprotein, spike protein, and open-reading body 8 (ORF8).”
#orf8
Media Coverage of GBRC Work on COVID
https://t.co/Q9KDRGE80D
@vnehra @ChaitanyaGJoshi @madhvijoshi
@gsbtm
#COVID19 #DeltaVariant #protein #orf8
Last Seen Hashtags on Sotwe
Omegle() + filter:videos
Seen from Switzerland
Teenage() +filter:native_video
Cleavage
Seen from Israel
mujdear
Seen from Turkey
رقص_منزلي
Seen from Egypt
momson filter:videos
Seen from Germany
jellybeanbrain
Seen from Turkey
esMarketingOnline
Seen from United Kingdom
reshmarechu
uksluts
Seen from Ireland
Most Popular Users
Elon Musk 
@elonmusk
240.9M followers
Barack Obama
@barackobama
119.2M followers
Donald J. Trump
@realdonaldtrump
111.8M followers
Cristiano Ronaldo
@cristiano
111.6M followers
Narendra Modi
@narendramodi
107M followers
Rihanna
@rihanna
97.9M followers
NASA
@nasa
92.2M followers
Justin Bieber
@justinbieber
91.1M followers
KATY PERRY
@katyperry
88.2M followers
Taylor Swift
@taylorswift13
82.1M followers
Lady Gaga
@ladygaga
73.6M followers
Virat Kohli
@imvkohli
70.8M followers
Kim Kardashian
@kimkardashian
70M followers
YouTube
@youtube
68.7M followers
Bill Gates
@billgates
64.2M followers
Neymar Jr
@neymarjr
63.6M followers
The Ellen Show
@theellenshow
62.4M followers
CNN
@cnn
61.8M followers
Selena Gomez
@selenagomez
61.3M followers
X
@x
60.8M followers