#OpenSourceDrugDiscovery - Twitter Hashtag

almost 5 years ago

COVID-19 restrictions have kept us out of the lab, so unfortunately we don't have any more current synthetic work to discuss right now. But that doesn't stop you from getting involved - #OpenSourceDrugDiscovery projects are larger than a single lab!

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Open Source TB @OpenSourceTB

almost 5 years ago

..but we had way more trouble with this one than expected - read about our trials and tribulations on @GitHub: https://t.co/c9YuEbJfQh #OpenSourceTB #OpenSourceDrugDiscovery #OpenScience

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Open Source TB @OpenSourceTB

almost 5 years ago

This fab illustration of the 6 laws of #OpenSourceDrugDiscovery features our sister project @O_S_M but the same principles apply to our work, too! If you're curious about them, read the paper here: https://t.co/gttU2HgC3k #OpenScience

#UniteHealth Social Media Awards @socmed4good

over 10 years ago

A vision in orange, #Malaria #Innovator @MatToddChem as envisioned by @_dangerouscake https://t.co/nEL2ZDxYin

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Open Source TB @OpenSourceTB

almost 5 years ago

Series 4 of #OpenSourceTB has a focus on diversity-oriented synthesis. Here’s one of the routes we planned to install a non-activated alkene. Our first reaction (acylation) had great yields… #MedChem #ChemTwitter #OpenSourceDrugDiscovery #OpenScience

OpenSourceTB's tweet photo. Series 4 of #OpenSourceTB has a focus on diversity-oriented synthesis. Here’s one of the routes we planned to install a non-activated alkene. Our first reaction (acylation) had great yields…

#MedChem #ChemTwitter #OpenSourceDrugDiscovery #OpenScience https://t.co/iiKiTTAwIq

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Open Source TB @OpenSourceTB

almost 5 years ago

We're also not the only ones trying to make #DrugDiscovery more open! Read about Huntington's disease reasearcher Dr Rachel Harding's experiences with #OpenScience here: https://t.co/drtwUqaRQb | @PLOSBiology #OpenSourceDrugDiscovery

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Open Source TB @OpenSourceTB

almost 5 years ago

Check out our @GitHub wiki to see what compounds we've made already and which ones we need help with - we'd love your suggestions or advice! #DrugDiscovery #OpenScience #OpenSourceDrugDiscovery https://t.co/WUjDwqNQyy

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Open Source TB @OpenSourceTB

almost 5 years ago

Right before lockdown got in the way, #OpenSourceTB were working towards this cyclam derivative with #ferrocene pendant groups: #OpenSourceDrugDiscovery #DrugDiscovery #ChemTwitter #Tuberculosis #MedChem

OpenSourceTB's tweet photo. Right before lockdown got in the way, #OpenSourceTB were working towards this cyclam derivative with #ferrocene pendant groups:

#OpenSourceDrugDiscovery #DrugDiscovery #ChemTwitter #Tuberculosis #MedChem https://t.co/GPpiPvaEYE

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Open Source TB @OpenSourceTB

almost 5 years ago

As mentioned, we wanted to try #adamantane as a hydrophobic pendant group on cyclam. Our proposed route was a click-coupling reaction between the bis-propargylated cyclam and azide-functionalised adamantane. #OpenSourceDrugDiscovery #OpenSourceTB #DrugDiscovery #ChemTwitter

OpenSourceTB's tweet photo. As mentioned, we wanted to try #adamantane as a hydrophobic pendant group on cyclam. Our proposed route was a click-coupling reaction between the bis-propargylated cyclam and azide-functionalised adamantane.

#OpenSourceDrugDiscovery #OpenSourceTB #DrugDiscovery #ChemTwitter https://t.co/jTBOtPHpgP

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Open Source TB @OpenSourceTB

almost 5 years ago

@Klemistry: Plus, I’m drawn to this more equitable approach to #DrugDiscovery. BC it’s not market-driven like big pharma, #OpenSourceDrugDiscovery can tackle #ntds (neglected tropical diseases) like #Tuberculosis that are less profitable, but still affect millions of people.

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Open Source TB @OpenSourceTB

almost 5 years ago

@Klemistry: #OpenSourceDrugDiscovery appeals to me because it acknowledges the collaborative effort that science is – and should be. Working together instead of on parallel tracks just makes sense – I'm hopeful that #OpenScience will save us time and money in the long run.

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Open Source TB @OpenSourceTB

almost 5 years ago

If you're interested in any of our #OpenSourceTB work so far, it's all available here on @github - you can find data on compounds, synthetic routes and all our publications in one spot! https://t.co/GtW4DfybDK #OpenSourceDrugDiscovery #DrugDiscovery #OpenScience #MedChem

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Open Source TB @OpenSourceTB

almost 5 years ago

Next up...the @GSK library furnished yet another lead compound for #OpenSourceTB Series 3. In 2015, OSTBS83 was identified by the Nathan lab (@WeillCornell) as a potent + selective Mtb inhibitor with low HepG2 toxicity. #Tuberculosis #DrugDiscovery #OpenSourceDrugDiscovery 1/

OpenSourceTB's tweet photo. Next up...the @GSK library furnished yet another lead compound for #OpenSourceTB Series 3. In 2015, OSTBS83 was identified by the Nathan lab (@WeillCornell) as a potent + selective Mtb inhibitor with low HepG2 toxicity.

#Tuberculosis #DrugDiscovery #OpenSourceDrugDiscovery 1/ https://t.co/Kj0giPLv07

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Open Source TB @OpenSourceTB

almost 5 years ago

So where does #OpenSourceTB fit into things? Well, #OpenSourceDrugDiscovery pioneer @MatToddChem oversaw the beginnings of this project back in 2013, when 177 lead compounds from the @GSK compound library were placed in the public domain... https://t.co/1rNUXnuXu6 #MedChem 1/

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Open Source TB @OpenSourceTB

almost 5 years ago

We think it's time for a refresher on what this project is all about! #OpenSourceTB is an #OpenSourceDrugDiscovery project, which is in turn part of the larger movement of #OpenScience. So – what does all that actually mean? /1

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Dana Klug @dana_klug

over 5 years ago

Draft agenda for today's OSA Series 2 meeting has been posted: https://t.co/dknIhvCOx4. Same time, same Zoom link @OSantibiotics @MatToddChem @macinchem @edwintse_ @LoriFerrins @mfernflower #antibiotics #openscience #opensourcedrugdiscovery #amr

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Dana Klug @dana_klug

over 5 years ago

Awesome contribution from @AtomwiseInc to @OSantibiotics using AI to design bacterial MurE inhibitors. Check out the structures here: https://t.co/YOgcv46WXI #openscience #opensourcedrugdiscovery #AMR

dana_klug's tweet photo. Awesome contribution from @AtomwiseInc to @OSantibiotics using AI to design bacterial MurE inhibitors. Check out the structures here: https://t.co/YOgcv46WXI #openscience #opensourcedrugdiscovery #AMR https://t.co/iSLDOigNyQ

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Dana Klug @dana_klug

over 5 years ago

Check out our first @OSantibiotics video update! https://t.co/36uzq9bGoc #openscience #opensourcedrugdiscovery #AMR

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Dana Klug @dana_klug

over 5 years ago

I've recorded my #CCGlobalSummit talk and put it up on YouTube: https://t.co/ypssMCyXyZ. If you're looking for a big-picture view of #opensourcedrugdiscovery this is the vid for you! Thanks again to @FinnWoelm and all the organizers for a great session!