Top Tweets for #PACLITAXEL
#ScienceLink #Madrid2026 #ESMO26 #COMPANION002 #Tovecimig #Paclitaxel
En COMPANION-002 (fase II/III; n=168), tovecimig + paclitaxel mejoró la TRO y la SLP frente a paclitaxel solo en 2L del cáncer de vía biliar avanzado/metastásico.
🧬 Tovecimig: anticuerpo biespecífico dirigido contra DLL4 y VEGF-A.
🎯 TRO: 18.0% vs 5.3% (p=0.0228)
Objetivo primario, evaluado por revisión central independiente.
⏳ SLP: 4.7 vs 2.6 meses
HR 0.44 (IC 95%: 0.30–0.66; p<0.0001)
📊 SG: 8.9 vs 9.4 meses
HR 1.05; p=0.78.
Sin diferencia estadísticamente significativa. El 54% del brazo control cruzó a la combinación tras progresión.
⚠️ EA emergentes durante el tratamiento:
Grado ≥3: 93.5% vs 64.2%.
Con desenlace fatal: 5.6% vs 1.9%, sin implicar necesariamente causalidad con el tratamiento.
🔗 Leer/escuchar noticia completa: https://t.co/8tpt93TlV1
#Optimization and detection of the #paclitaxel-engineered strain.
🔗https://t.co/9UrLkln8Kz
#PlantScience #Moss #SyntheticBiology @Moon_Synth_Bio @CellAtlas @sci_plant @TrendsBiochem @ScienceNews @PlantEngMag @plant_met_engg @NatureComms @NaturePlants @CropGlobal @plantae_org
Stable #expression of the complete #paclitaxel biosynthetic pathway in #Physcomitrium patens using a modular #vector system.
🔗https://t.co/9UrLkln8Kz
#PlantSci @NatureComms @PlantEditors #Moss #SyntheticBiology @SynBioBeta @sci_plant @sciplant17 @plantbiocore @plant_met_engg
Transient #expression in #Physcomitrium patens enables heterologous biosynthesis of #baccatin III and #paclitaxel.
🔗https://t.co/9UrLkln8Kz
@NatureComms @NaturePlants @NatureBiotech @sci_plant @Moon_Synth_Bio @OUPSynBio @bioRxiv_synbio #PlantSci #Moss #SyntheticBiology
Happy to share our🆕#OpenAccess article "#Engineering the #paclitaxel biosynthetic pathway in #Physcomitrium patens for de novo and stable biosynthesis🧬🌿" is now published in @NatureComms🥳🎉
Congrts to all authors👏
🔗https://t.co/9UrLkln8Kz
@ShenzhenUni @sci_plant #plantsci
Dr Reddy's gets DCGI nod for Zytorvi in advanced esophageal cancer
https://t.co/1SUgPGcBVD
#Dr.Reddy'sLaboratories
#CentralDrugsStandardControlOrganisation #immunotherapydrug #Zytorvi #toripalimab #cisplatin #paclitaxel
@indpharmapost
抗がん剤で安定化した微小管に潜む「ナノ欠陥」
―高速ＡＦＭで崩壊の瞬間を捉えた！―
論文URL:
https://t.co/G1Xnsgkci9
NanoLSIウェブサイト:
https://t.co/x4pp7gr5MQ
#高速AFM #微小管 #Paclitaxel #chemo #microtubule #がん #抗がん剤
Nature as a Remarkable Chemist: A Personal Story of the Discovery and Development of Taxol®
Mansukh C Wani , Susan Band Horwitz #paclitaxel Anticancer Drugs. 2014 May;25(5):482–487.
https://t.co/55K810mIJP
📖New analysis of the AGENT IDE trial, treatment with #paclitaxel-coated vs uncoatedballoon was safe & effective for treating patients with #coronary #ISR across a spectrum of #restenosis risk. Read more today:
➡️https://t.co/oOaK4Hu6mq
@PrakritiGaba @KateKearney4 @rwyeh @JDawnAbbott1 @FaroucJaffer
💥Excited for the publication: "Integrated Computational Modeling Reveals a Structurally Plausible Transient Paclitaxel–NK2R Interaction"
🔗https://t.co/T52p6Crz83
📌 #Paclitaxel #BreastCancer #MolecularDocking #MolecularDynamics #ComputationalBiology #Bioinformatics
💊 Pairing albumin-bound #paclitaxel with #anlotinib showed promise in a tough-to-treat, platinum-resistant #ovariancancer trial.
【Albumin-bound paclitaxel plus anlotinib in patients with recurrent, platinum-resistant primary epithelial ovarian cancer (A-Plus): a phase II, single-arm, prospective study】
https://t.co/Goq3T3S7BX
#ENGINEERINGMedicine
Souto Seguin et al. examined the impact of #genetic variations in #ABCB1 & #ABCC2 #genes on the incidence of adverse drug reactions and survival in non-small cell lung cancer patients treated with #carboplatin and #paclitaxel.
#ADR #NSCLC #Pharmacogenetics
https://t.co/OxAgfHSPOD
Article✍️#Heterocyclic modified #paclitaxel #prodrug #nanoassemblies for stimuli-responsive delivery via #lysosomal escape.
From Dr. Sun @ShenyangPharmaceuticalUniversity;
https://t.co/c8HDgpE1UY.
Updates from #SGO26: Final #OS results from the phase 3 #ROSELLA trial demonstrate that the addition of #relacorilant to nab-#paclitaxel significantly improves survival in platinum-resistant #ovarian cancer. Learn more: https://t.co/yKTySPwVHs
#medtwitter #onctwitter
The FDA just changed how we sequence
Platinum Resistant #OvarianCancer . Yesterday’s approval of #Relacorilant (Lifyorli) + nab-
#paclitaxel (March 25, 2026) moves us past "chemo-switching" and into Resistance-Modulating. The utility here is pure biology: we’re finally targeting the Glucocorticoid Receptor (GR) "stress shield" to re-sensitize the tumor to the taxane. The #ROSELLA trial data speaks for itself: 35% reduction in risk of death (HR 0.65). OS: 16.0 mo vs 11.9 mo. 1–3 prior lines, including Bev. No biomarker needed!
☑️Dismantling GR signaling works across the board.
>>Between this and the Feb 10 FDA approval of #Pembrolizumab/#paclitaxel (#KEYNOTEB96) for PD-L1+ cases, our 2026 algorithm is finally specialized:
1- Hit the PD-1 for immune evasion.
2- Hit the GR for stress evasion.
This data published in @TheLancet is the blueprint for the next generation of PROC sequencing.
@GOG @ESGO_society @ENYGO_official @OncoAlert @GynMe4
🥳First Paper Published in the #SpecialIssue!
Title: A Phase 1 Dose Escalation of Lapatinib and Paclitaxel in Recurrent #OvarianCancer
✍Authors: Connie D. Cao, @deanjillkolesar et al.
🔗Read it here: https://t.co/13XSDHPJjA
#lapatinib #paclitaxel #recurrent ovarian cancer
A #NatureCommunications study shows that transient #BloodBrainBarrier (#BBB) opening triggers a rapid surge of tumor‑derived extracellular particles in the bloodstream, providing a minimally invasive biomarker for #glioblastoma susceptibility to #paclitaxel. This real‑time signal could help personalize therapy after a single treatment. https://t.co/znO6s5m6ha
Short Communication✍️ #Rapid in #vivo release of #paclitaxel from #polymeric #micelles. From Dr. Wu @FudanUniversity;
https://t.co/kznweIVqhR.
Bench abrasion test (8 DCBs): #ELUTAX had the lowest drug lost - measured by deflated-state coated-area change (“virtually no change”, 2.31±2.03%) . Others: 15.82–45.73%. High-abrasion tracking is a problem in distal #vessels or #ureter. #endourology #Paclitaxel #Dextran #arbalticmedical #Optilume #Laborie source: https://t.co/nEBiCuyP2g
@PurumittalDr @realarainmd @SVRaoMD @jedicath @SarahFairley7 @saraceciliamtz @CtoEuro It is not about #DCB hype.
Indication for
1) #lesionpreparation to achieve size and flow
2) drug (#sirolimus #paclitaxel) to prevent restenosis
Oral drug more side effect than #DCB
3) scaffolding to prevent acute closure (single digit chance, no catastrophe if collateralized)
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