Top Tweets for #POLYA
December 13, 1887 — George Pólya was born.
Author of How to Solve It, he transformed how we teach problem-solving through heuristics like “draw a diagram” and “guess and check.” His ideas still guide mathematics education today. ✏️📘
#OnThisDay #Mathematics #Polya
PolyA_DB v4: systematic polyA site identification and isoform annotation in human and mouse genomes using 3′ end and long-read sequencing data.#PolyA #IsoformAnnotation #Genomics #Bioinformatics #NAR
https://t.co/olIDURBqcn
@ObscureYumes I think op might have better luck just editing images together. This was made in a dress up app called lily story :))
Also I can't shut up about this, pls try to use #polyam or #polya instead of poly! Poly is used by Polynesian people and they have asked us to stop
Any poly yumes ? ♡
6/ Polya (1945) deuno no cravo: resolver problemas é buscar solucións, explorar patróns e formular conxecturas, non só memorizar fórmulas. Demos aos nenos problemas que esperten curiosidade, non só exercicios rutineiros! 🔥 #Polya #MentalidadeMatemática
A spatial long-read approach at near-single-cell resolution reveals developmental regulation of splicing and polyadenylation sites in distinct cortical layers and cell types. #LongReads #SingleCell #Spatialtranscriptomics #IsoSeq #PolyA @NatureComms
https://t.co/kqcfPnxO15
El quehacer
matemático es un pensar
“voluntario”, un pensar di-
rigido hacia unos objetivos.
George #Polya nos decía: “Sería un error el creer que la solución de un problema es un
asunto puramente intelec-
tual; la determinación, las
emociones, juegan un papel importante.⬇️
Benchmarking of methods that identify alternative polyadenylation events in single-/multiple-polyadenylation site genes. #PolyA #MethodBenchmarking #Genomics #NARgenomicsAndBioinformatics
https://t.co/Oa7HQCPR23
We then detected the same #polyA elongation pattern in #macrophages - both those sorted from muscles surrounding injection sites and in the in vitro models (mouse bone marrow-derived macrophages (mBMDMs) and human monocyte-derived macrophages (hMDMs)). (8/n)
Crucially, when examining #mRNA #vaccines at injection sites in #mice, we discovered an unexpected phenomenon: #polyA tails were extended from ~100 to ~200 nucleotides - contradicting the expected degradation pattern observed in standard cell lines. (7/n) #mRNAStability
To overcome this obstacle, I developed a Dynamic Time Warping approach to detect and analyze vaccine molecules using #DRS with high fidelity, enabling precise characterization of #polyA tails from #therapeutic #mRNAs. (4/n)
We employed @nanopore #direct #RNA #sequencing (DRS) to characterize individual therapeutic mRNA molecules - specifically focusing on #polyA #tail dynamics. However, #methylpseudouridine (mΨ) modifications in therapeutic mRNAs create significant analytical challenges. (3/n)
The latest achievement from the lab, Ninetails, published at @NatureComms. This is the first fully #bioinformatics paper from the lab. Huge congrats to @nemithesaura. #RNA #nanopore #polyA #nonadenosines
I am happy to share our most recent results published in Nature Communications. Ninetails - a pipeline for detection of non-adenosines in poly(A) tails of Oxford Nanopore Direct RNA Sequencing reads.
Many thanks to LBR lab members for this work.
https://t.co/1YXBLxrMWs
A very insightful work into #lncRNA parallel functions, U1-dependent #chromatin association, and alternative #polyA site selection.
I am delighted to be part of this work led by Szymon Swiezewski and Sebastian Sacharowski.
⚠️ Preprint
https://t.co/y2bZiBku0I
It's been a while, but I'm trying to get back into a routine with the Poly-ish Movie Review podcast, so a new episode is out! https://t.co/bTKQDCpqrU
#polyamory #polyamorous #poly #polya #polyam #nonmonogamy #MovieReviews
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