Top Tweets for #ProteinDisorder
Intrinsically disordered regions (IDRs) play key roles in cell cycle regulation! Explore how flexible IDRs and SLiMs enable complex, dynamic control of cyclin-dependent kinases. #IDRs #CellCycle #ProteinDisorder #COSB #StructuralBiology
https://t.co/GQ8WbwAASO
🧬 How do SARS-CoV-2 mutations boost fitness?
With #ISIDORe, Blackledge (IBS Grenoble) used high-field NMR to show that N protein mutations (e.g. Q229K, R203M) reshape structure & RNA binding.
Disorder = function.
#SARSCoV2 #Nucleocapsid #NMR #ViralFitness #ProteinDisorder
Just published in @NAR_Open: CAID Prediction Portal, a comprehensive web server for predicting intrinsic disorder & binding regions in proteins. Our blind-test benchmarks different methods, promoting easy comparison & consensus prediction #proteindisorder
https://t.co/arh3iHb43a
Soft disorder (flexible + disorder-to-order regions) is directly involved in protein assembly and migration of soft disorder after binding gives rise to new or altered functions in the protein complex. With Beatriz Seoane
@ScienceSorbonne @unicomplutense #ProteinDisorder
Soft disorder modulates the assembly path of protein complexes - see also how SD in assembly paths correlates with AF2 low confidence regions in unbound structures https://t.co/EEM3e00xna - with Beatriz Seoane
@unicomplutense @LCQB_UMR7238 @ScienceSorbonne #ProteinDisorder
A big community effort summarized by this nice publication in @naturemethods about protein intrinsic disorder prediction. Thanks @BioComputingUP for leading this project and moving forward the IDP community #proteindisorder #prediction
1/6 Is predicting intrinsically disordered regions (#IDRs) prediction a solved problem? In our new @naturemethods paper we demonstrated that disorder is more than the absence of structure and that machine learning strongly impacts prediction accuracy
https://t.co/FBGZBwGuQs
Our analysis of "soft disorder" makes the cover of the PLoS Computational Biology January issue: https://t.co/ZZUV52xpF3
#ProteinDisorder
Finally published! ProminTools: for comparing two sets of protein sequences. Aimed at biomineral proteins, but applicable any, particularly disordered / biased AA composition.
#biomineralization #proteindisorder #mollusc #amyloid @MPIMP_Potsdam
https://t.co/W69i4LdYwP
Spatiotemporal characterization of the human nucleolar #proteome --> https://t.co/myGatadVjP
@Prof_Lundberg @KTHuniversity @scilifelab @czbiohub @ProteinAtlas #nucleolus #proteindisorder #proteomics
Analysis of peptides by chemically creative mutagenesis — a review #proteindisorder #cyclicpeptides #proteinfolding #peptidedrugs @novonordiskfond
https://t.co/iSnVDkhJct
Benjamin's paper is out 👍 He shows how abundance constrains disordered regions in the yeast and human proteomes. #proteinscience #yeast #evolution #proteindisorder https://t.co/s64dnrSHPD
Gábor Erdos presents #bioinformatics methods and #databases for #proteinDisorder prediction at #IDPfun training school @fundacionleloir
Hands on #sequenceMotifs in #ELM @embl with @luchemes at #IDPfun training school @fundacionleloir #proteinDisorder #bioinformatics
Dr. Balint Meszaros about the #proteinInteractions mediated by #IDPs @fundacionleloir at #IDPfun training school #bioinformatics #proteinDisorder
Dr. Peter Tompa opens the #IDPfun training school in @fundacionleloir with an introduction about #proteinDisorder. Thanks to the local organizer @cristina_buslje
#mdpientropy Entropy, Fluctuations, and Disordered Proteins https://t.co/aBD08RR7Nh
#proteindisorder
#proteinstructure
#entropy
#fluctuations
#mutations
Look at our latest pre-print about "Ensembles from ordered and disordered proteins reveal similar structural constraints during evolution" #proteindisorder #ensembles #evolution https://t.co/zQN8XYVRvl
“Protein disorder is a powerful medium that can fuel the evolution of organism complexity & diversity through the creation of novel networks of interactions” - M. Madan Babu @MRC_LMB
#proteinstructure #proteindisorder #proteinfunction #ISMB18 #ISMB2018 #keynote
Thanks @MSCActions for mentioning my #SealofExcellence grant by the University of Padova @UniPadova in the @BiocomputingUP @IdPfun #Bioinformatics #IDPensembles #ProteinDisorder https://t.co/lNTbyfifN1
Last conference day in Kosice with @NPalopoli and @gusparisi #NGPnet #ProteinDisorder #Bioinformatics #ArgertinianTeam @cost_ngpnet
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