Top Tweets for #RFdiffusion
📖 For further insights:
🔗 https://t.co/441tLNH7pO
Author: Melissa Öner
Editor: Elinsu Ak
Visual Design: Gizem Akcagündüz
#bioinfocodes #gpcr #rfdiffusion #proteindesign #cryoem
ナノマシン前駆体⁉
この回転する画像は #タンパク質 の立体モデルなんだ！
返信に「RFdiffusion3で生成した」とある。
#RFdiffusion は タンパク質をゼロから人工設計するためのAIシステム
立体構造を予測するAIではなく、目的に合った形や機能を持つタンパク質を生成することに特化
画像生成AIで使われる「拡散モデル（ディフュージョンモデル）」を応用している。最初はランダムなアミノ酸の塊（ノイズ）からスタートし、段階的にノイズを取り除きながら、自然界に存在しない理想的な立体構造（バックボーン）を構築する。
へ～‼ それで👇I44みたいな #20・12面体（五角形12面と三角形20面）のタンパク質が生成できるのね😃
nanomachine precursors
Incase you are interested in Protein Design. This short series will teach you, the basic theory and practical startup for free.
https://t.co/LTli1JadYT
#Biology #AI #Proteindesign #RFdiffusion #colab #theory
📷クイズ！動画内でMDMXに結合するタンパク質を指定するために使用した、アミノ酸の長さを示すパラメータは何？ヒントは「A:コロン〇〇」。正解は動画の2:50〜で確認！
https://t.co/GyxGU9OBow
#タンパク質設計 #RFDiffusion
RF Diffusion、ProteinMPNN、AlphaFold2を組み合わせたタンパク質デザインのワークフロー解説動画が公開。In Silico創薬の基礎を解説。
https://t.co/M6p9OzBdgV
#AI創薬 #タンパク質デザイン #RFDiffusion
CellとNatureに掲載された抗体生成AIについて勉強しました！
#MAGE #RFdiffusion
配列ベースMAGE vs 構造ベース拡散モデルRFdiffusion-Ab（RFantibody）
https://t.co/zjPiqeRHCV
We were happy to host Ibuki & Aya from #Keio University for the #OIST–KEIO Summer School!
They learned to design proteins with #BindCraft & #RFDiffusion, express them in bacteria, and purify our stunning blue antenna proteins. 💙✨
#ProteinDesign #MolBioEng-lab #STEMeducation
I am thrilled to release ProteinDJ: a high-performance and modular protein design pipeline. Our open-source workflow incorporates #RFdiffusion, #ProteinMPNN, #FAMPNN, #AlphaFold2 and #Boltz-2. It is a fast, free, and fun way to design proteins (1/5)
https://t.co/IOlC0JKvOL
If one wants to de novo predict protein structures, they must first obtain master level black belt status in virtual python environments! #rfdiffusion
An impactful proof-of-concept preprint! @UWproteindesign fine-tunes #generativeAI tool #RFdiffusion to create de novo single-domain #antibodies—a big step toward designing complex antibodies that could revolutionize drug development
https://t.co/BSTRV4r51T
One highlight of this paper for me is where we show #RFdiffusion is capable of generating nontrivial backbone features that enable high-affinity interface design with non-idealities such as broken helices, and cross-interface hydrogen bonds as shown in the Bim xtal structure
A new Machine Learning Engineer position is open in our group! Come to work with us on developing open-source AI tools for drug discovery and biomedicine such as #DiffDock, #FrameDiff, #RFDiffusion, and many more! (Please RT!)
Join us at #JameelClinic, a global hub leading in knowledge, innovation, and AI for health + biotech! If you're a machine learning engineer, we invite you to become an integral member of this dynamic ecosystem.
🌟Apply now: https://t.co/cIBd56rwzE
이거 모양은 그럴싸한 단백질이 막 만들어지는데 진짜로 유전자 합성해서 만들어보고 싶네 ㅋㅋㅋㅋ #RFdiffusion
In case you missed it, make sure to check out our recent video where we dip our toes into the awesome world of AI protein generation!
https://t.co/TvuOcL172G
Sending many thanks to @UWproteindesign, @_JosephWatson 's team and all else involved for open-sourcing #RFDiffusion :)
#ProteinDesign & #AI using #RFDiffusion - Now free and #OpenSource:
https://t.co/FvliqV0tJN
Corresponding preprints:
#1: https://t.co/0CrKatO4yZ
#2: https://t.co/hRW8dB7Vfj
GitHub: https://t.co/RggAX18m75
#DIYbio #bioinformatics #CompChem
Playing with the amazing #RFdiffusion Colab notebook (it's just awesome!). Having "issues" with flying peptides, mpnn_results.csv reports RMSD of 10.0Å-30.0Å. Is this something expected for small binders @sokrypton, @_JosephWatson ? Let me know if I could be of any help! 🙏🏻
Another day, another reason to not sleep :(
Can't wait to tear through this.
#protein #ai #RFdiffusion #compbio
https://t.co/ACb73nsdaR
いま作ってみた5
左: RFDiffusion生成構造、右: ProteinMPNNで配列生成してESMFoldで予測した構造
半分TIMバレルで半分二重βバレルという胸が熱くなるフォールドが生成されたが、残念ながら目的構造に折りたたむと予測される配列は得られなかった。
#RFDiffusion #ProteinMPNN #ESMFold
いま作ってみた5
左: RFDiffusion生成構造、右: ProteinMPNNで配列生成してESMFoldで予測した構造
これはさすがに巻かないだろうと思ったが、ESMFoldで巻いた構造が予測されてきた。本当に？
ESMFoldは"巻きがち"な感じがするが、この結果もそれかもしれない。
#RFDiffusion #ProteinMPNN #ESMFold
いま作ってみた3
左: RFDiffusion生成構造、右: ProteinMPNNで配列生成してESMFoldで予測した構造
#RFDiffusion on colaboratory--> #ProteinMPNN ---> #ESMFold
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