#RO52 - Twitter Hashtag

7 months ago

Anti-#Ro52 and anti-#Ro60 profiles define distinct #Sjögren’s disease (SjD) subsets, as demonstrated by a retrospective study of 725 primary SjD patients stratified by anti-Ro52/Ro60 status: ◦ Distribution: 50.6% double-positive (Ro52⁺Ro60⁺), 17.7% Ro52⁺Ro60⁻, 10.2% Ro52⁻Ro60⁺, 21.5% double-negative. ◦ Anti-Ro52 positivity (Ro52⁺Ro60⁻ and Ro52⁺Ro60⁺) → significantly higher ESSDAI scores (greater disease activity). ◦ Double-positive (Ro52⁺Ro60⁺) independently associated with: - Renal involvement (OR 5.53) - Cutaneous involvement (OR 2.49) - Hyperglobulinemia (OR 5.19) - Low complement (OR 1.70) ◦ Isolated Ro52⁺ (Ro52⁺Ro60⁻) specifically linked to interstitial lung disease (OR 4.17). ◦ Significant synergistic interaction between anti-Ro52 and anti-Ro60 for hyperglobulinemia. These findings indicate that anti-Ro52 positivity marks higher severity, and double positivity identifies a multi-organ, hyperactive immune phenotype. Routine separate testing for anti-Ro52 and anti-Ro60 can improve systemic risk stratification SjD patients. *Zhang Q, Zhang L, Lv L, et al. Serological stratification by anti-Ro52 and anti-Ro60 profiles reveals distinct systemic phenotypes in primary Sjögren's disease. Semin Arthritis Rheum. Published online February 10, 2026. 🔗https://t.co/bozapnEG8H

alb_giraldo's tweet photo. Anti-#Ro52 and anti-#Ro60 profiles define distinct #Sjögren’s disease (SjD) subsets, as demonstrated by a retrospective study of 725 primary SjD patients stratified by anti-Ro52/Ro60 status:
◦ Distribution: 50.6% double-positive (Ro52⁺Ro60⁺), 17.7% Ro52⁺Ro60⁻, 10.2% Ro52⁻Ro60⁺, 21.5% double-negative.
◦ Anti-Ro52 positivity (Ro52⁺Ro60⁻ and Ro52⁺Ro60⁺) → significantly higher ESSDAI scores (greater disease activity).
◦ Double-positive (Ro52⁺Ro60⁺) independently associated with:
- Renal involvement (OR 5.53)
- Cutaneous involvement (OR 2.49)
- Hyperglobulinemia (OR 5.19)
- Low complement (OR 1.70)
◦ Isolated Ro52⁺ (Ro52⁺Ro60⁻) specifically linked to interstitial lung disease (OR 4.17).
◦ Significant synergistic interaction between anti-Ro52 and anti-Ro60 for hyperglobulinemia.

These findings indicate that anti-Ro52 positivity marks higher severity, and double positivity identifies a multi-organ, hyperactive immune phenotype. Routine separate testing for anti-Ro52 and anti-Ro60 can improve systemic risk stratification SjD patients.

*Zhang Q, Zhang L, Lv L, et al. Serological stratification by anti-Ro52 and anti-Ro60 profiles reveals distinct systemic phenotypes in primary Sjögren's disease. Semin Arthritis Rheum. Published online February 10, 2026.
🔗https://t.co/bozapnEG8H

0

56

33

22

2K

Alberto Giraldo @alb_giraldo

almost 2 years ago

Biomarkers in Systemic Sclerosis-associated Interstitial Lung Disease #Rheumatology #SystemicSclerosis #Scleroderma #ILD #Biomarkers #Scl70 #Ro52 *From: Bazsó, A., Szodoray, P., Shoenfeld, Y. et al. Biomarkers reflecting the pathogenesis, clinical manifestations, and guide therapeutic approach in systemic sclerosis: a narrative review. Clin Rheumatol 43, 3055–3072 (2024). 🔗https://t.co/DIuG8mtTcz

alb_giraldo's tweet photo. Biomarkers in Systemic Sclerosis-associated Interstitial Lung Disease

#Rheumatology #SystemicSclerosis #Scleroderma #ILD #Biomarkers #Scl70 #Ro52

*From: Bazsó, A., Szodoray, P., Shoenfeld, Y. et al. Biomarkers reflecting the pathogenesis, clinical manifestations, and guide therapeutic approach in systemic sclerosis: a narrative review. Clin Rheumatol 43, 3055–3072 (2024).
🔗https://t.co/DIuG8mtTcz

1

44

19

21

4K

Alberto Giraldo @alb_giraldo

about 2 years ago

The combination of anti-#Ro60/SSA and anti-#Ro52/TRIM21 antibodies is associated with a clinical, biologic, and transcriptional profile linked to greater disease severity in #Sjögren’s disease through the potentiation of the #interferon pathway activation by anti-Ro52/TRIM21 antibodies. 🔗https://t.co/5mYCmMd8W9

0

3

2

1

305

The Journal of Rheumatology @jrheum

over 3 years ago

Editorial Ro52, Myositis, and Interstitial Lung Disease 📰 https://t.co/dkc88do87v #Ro52 #myositis #interstitiallungdisease

0

74

29

8

13K

elsjogrenbajolacapa @elsjogrenbajol1

over 5 years ago

#Neumopatía #intersticial en #sjogrens #sjögren Factores de riesgo: sexo masculino, #tabaquismo, #sjogren primario, #Ro52, #linfocitos >15% en el BAL #MedTwitter #medicinainterna #Medical #MedEd #autoinmune #autoimmunedisease #rheumaticdisease #SjögrenSER @GEAS_SEMI @GTEASSER

GEAS SEMI @GEAS_SEMI

over 5 years ago

@MaykaFreire @PFanlo @fjrascon @GeasNavarra @GeasMadrid @joraltron @cpsimeon @JJRiosBlanco @bcgraciatello 🩺⚠️#Neumopatía #intersticial en el #síndrome de #Sjögren (#SS). 🫁 Factores de riesgo: sexo masculino, tabaquismo, SS primario, #Ro52, linfocitos >15% en el BAL Más info en: GEAS-SS SEMI Registry #registrosGEAS #registroSjögrenGEAS https://t.co/cJ9cOnL0T1

GEAS_SEMI's tweet photo. @MaykaFreire @PFanlo @fjrascon @GeasNavarra @GeasMadrid @joraltron @cpsimeon @JJRiosBlanco @bcgraciatello 🩺⚠️#Neumopatía #intersticial en el #síndrome de #Sjögren (#SS). 🫁
Factores de riesgo: sexo masculino, tabaquismo, SS primario, #Ro52, linfocitos >15% en el BAL
Más info en: GEAS-SS SEMI Registry
#registrosGEAS #registroSjögrenGEAS
https://t.co/cJ9cOnL0T1 https://t.co/dUf1n2Hxur https://t.co/5gWMJVBair

0

8

4

0

9

5

0

GEAS SEMI @GEAS_SEMI

over 5 years ago

@MaykaFreire @PFanlo @fjrascon @GeasNavarra @GeasMadrid @joraltron @cpsimeon @JJRiosBlanco @bcgraciatello 🩺⚠️#Neumopatía #intersticial en el #síndrome de #Sjögren (#SS). 🫁 Factores de riesgo: sexo masculino, tabaquismo, SS primario, #Ro52, linfocitos >15% en el BAL Más info en: GEAS-SS SEMI Registry #registrosGEAS #registroSjögrenGEAS https://t.co/cJ9cOnL0T1

0

8

4

0

GEAS SEMI @GEAS_SEMI

over 5 years ago

@MaykaFreire @PFanlo @fjrascon @GeasNavarra @GeasMadrid @joraltron @cpsimeon @JJRiosBlanco @bcgraciatello 🩺⚠️#Neumopatía #intersticial en #enfermedad #mixta del #tejido #conectivo (#EMTC). Recordar la diferencia entre #EMTC, enfermedad #indiferenciada y #síndromes de #solapamiento Factores de riesgo para EPI: #disfagia, #Raynaud, #Ro52, #FR, entre otros https://t.co/3hb7Psr6eH

0

14

5

1

0

Latika @LatikaGupta_

almost 6 years ago

Intriguing- new ideas flowing in each day! In #COVID-19, a high level of anti-#SSA/#Ro52 antibodies may be a surrogate marker of #pneumonia severity and poor #prognosis. https://t.co/lOeYJN1J1z

0

11

4

1

0