#SLFN11 - Twitter Hashtag

6 months ago

📖 New online from our group at @MDAndersonNews Mechanisms of Resistance to Trastuzumab-DXd in #LungCancer 🔬✨ Key findings: 👉 Payload resistance driven by #SLFN11 loss and copy-number gains in the efflux pump ABCC1/MRP1 👉 Secondary #HER2 extracellular domain mutations at the antibody binding site (e.g., D582, F595) 👉 Tumors with acquired payload resistance or domain IV mutations retain HER2 signaling and remain sensitive to TKIs, including #zongertinib and #sevabertinib 💡 🎊 🔥 This is the first comprehensive preclinical and clinical investigation of #ADC #MoR in lung cancer, with direct therapeutic implications. https://t.co/8zKNB2FpkQ

LeXiuning's tweet photo. 📖 New online from our group at @MDAndersonNews Mechanisms of Resistance to Trastuzumab-DXd in #LungCancer 🔬✨ Key findings:
👉 Payload resistance driven by #SLFN11 loss and copy-number gains in the efflux pump ABCC1/MRP1
👉 Secondary #HER2 extracellular domain mutations at the antibody binding site (e.g., D582, F595)
👉 Tumors with acquired payload resistance or domain IV mutations retain HER2 signaling and remain sensitive to TKIs, including #zongertinib and #sevabertinib
💡 🎊 🔥 This is the first comprehensive preclinical and clinical investigation of #ADC #MoR in lung cancer, with direct therapeutic implications.
https://t.co/8zKNB2FpkQ

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FJ @pistoto2017

10 months ago

https://t.co/ikjNhNU1BS #STS #sarcoma #lurbinectedin #zepzelca #pharmamar #cancer #berzosertib #SLFN11 #AACR25 @PhrmMar

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Sarah@難病末期癌からの生還 @sarah_miracosta

over 1 year ago

1634[#ガン治療] #抗がん剤の効果高めるたんぱく質「#SLFN11」とは愛媛大が仕組み解明☑️ *** 父はどのようにして末期癌を短期に完治させたのか❓ #卵巣がん #肝臓がん #乳がん #咽頭がん #胃がん #膵臓がん #大腸がん #子宮がん #肺がん https://t.co/GSfnflh2FH

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Stephen V Liu, MD

@StephenVLiu

over 1 year ago

SWOG S1929 @JTOonline: phase II of maintenance atezolizumab +/- PARP inhibitor talazoparib in #SLFN11+ #SCLC. Meets PFS endpoint (2.9m vs 2.4m, HR 0.66) but no OS impact OS (HR 0.98). No impact on practice but proof of principle for biomarker studies. https://t.co/h2vgRUYAPk

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OncoAlert

@OncoAlert

about 3 years ago

The #OncoAlertTopTweet 🚨 Day 2⃣ #ASCO23 🇺🇸 Tweet by @OncoAlert Faculty @CharuAggarwalMD The SWOG S1929 Trial of atezo +| - talazoparib in #SCLC maintenance in #SLFN11 positive pts ✨ mPFS improved Best, @weoncologists

Charu Aggarwal, MD, MPH, FASCO

@CharuAggarwalMD

about 3 years ago

#ASCO23 @ASCO #SCLC @SWOG Trial of atezo +| - talazoparib in #SCLC maintenance in #SLFN11 positive pts ✨ mPFS improved ✨ this demonstrates that biomarker driven studies are feasible @OncoAlert Fantastic job @NaglaAKarimMD

CharuAggarwalMD's tweet photo. #ASCO23 @ASCO
#SCLC @SWOG Trial of atezo +| - talazoparib in #SCLC maintenance in #SLFN11 positive pts
✨ mPFS improved
✨ this demonstrates that biomarker driven studies are feasible
@OncoAlert
Fantastic job @NaglaAKarimMD https://t.co/1OIUBkJ6QG

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Charu Aggarwal, MD, MPH, FASCO

@CharuAggarwalMD

about 3 years ago

#ASCO23 @ASCO #SCLC @SWOG Trial of atezo +| - talazoparib in #SCLC maintenance in #SLFN11 positive pts ✨ mPFS improved ✨ this demonstrates that biomarker driven studies are feasible @OncoAlert Fantastic job @NaglaAKarimMD

Charu Aggarwal, MD, MPH, FASCO

@CharuAggarwalMD

about 3 years ago

#ASCO23 @ASCO Abs#8504 Data next up! SWOG S1929: Phase II trial of maint atezo vs atezo + talazoparib in SLFN11 + #SCLC @NaglaAKarimMD #LCSM

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Stephen V Liu, MD

@StephenVLiu

over 3 years ago · Manhattan

At #SCLC23 where Dr. @LaurenByersMD gives a wonderful overview of DNA Damage Response (DDR) inhibitors in #SCLC. PARP inhibitors continue to show promise. Is #SLFN11 the biomarker that brings these drugs to routine use? Expect results from S1929 at #ASCO23

StephenVLiu's tweet photo. At #SCLC23 where Dr. @LaurenByersMD gives a wonderful overview of DNA Damage Response (DDR) inhibitors in #SCLC. PARP inhibitors continue to show promise. Is #SLFN11 the biomarker that brings these drugs to routine use? Expect results from S1929 at #ASCO23 https://t.co/5vCIzNoi18

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新潟発！！地域情報サイト「ミンツ」 @mints_niigata

over 3 years ago

小児悪性脳腫瘍（髄芽腫）において化学療法の効果を高める遺伝子を特定 https://t.co/PWli3wTXms #新潟大学 #脳研究所 #SLFN11 #小児悪性脳腫瘍 ※新潟大学脳研究所脳神経外科分野の棗田助教、藤井教授らの研究グループ／科学雑誌Neuro-Oncology誌に掲載...

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新潟大学脳研究所（公式） @niigata_nouken

over 3 years ago

【研究成果】脳神経外科学の棗田助教，藤井教授らの研究グループは病理学の柿田教授，慶應義塾大学の村井特任准教授らと多施設共同研究を実施し，小児悪性脳腫瘍である髄芽腫に対する化学療法の効果を高める遺伝子としてSLFN11を特定しました🎯👉👉 https://t.co/ZASjnSTBE7 #脳研究 #髄芽腫 #SLFN11

niigata_nouken's tweet photo. 【研究成果】脳神経外科学の棗田助教，藤井教授らの研究グループは病理学の柿田教授，慶應義塾大学の村井特任准教授らと多施設共同研究を実施し，小児悪性脳腫瘍である髄芽腫に対する化学療法の効果を高める遺伝子としてSLFN11を特定しました🎯👉👉 https://t.co/ZASjnSTBE7
#脳研究 #髄芽腫 #SLFN11 https://t.co/KOamHdp6p4

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EMDB - EMPIAR @EBI @EMDB_EMPIAR

almost 4 years ago

Explore this & the other newly released data now @EMDB_EMPIAR EMDB: https://t.co/WgCgswGg8e PDBe: https://t.co/LSyc5ejdza Paper: https://t.co/a4cHSzZCGg #StructuralBiology #CryoEM #SingleParticle #Human #SLFN11 #apo

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MarinePharmacology.org @MarinePharmaco1

over 4 years ago

These data confirm the activity of #lurbinectedin across a large cohort of #SCLC models and identify #SLFN11 as a top candidate biomarker for lurbinectedin sensitivity. #MarineNaturalProducts #FDAApproved #MarineDrugs https://t.co/OFPucPnm5S

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Dr. Nagla Abdel Karim

@NaglaAKarimMD

over 5 years ago

S1929: A personalized approach clinical trial for Small Cell Lung Cancer; where SCLC is Not going to be considered as One disease anymore. #SLFN11 @SWOG @LaurenByersMD @drgandara

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Stephen V Liu, MD

@StephenVLiu

about 7 years ago

#SCLC symposium- @NReguart summarizing some promising advances in targeted agents and small molecules including #PARP inhibition, CHK, AAK, WEE1. We just need to find the right predictive markers and enrich study populations. #LCSM #SLFN11

StephenVLiu's tweet photo. #SCLC symposium- @NReguart summarizing some promising advances in targeted agents and small molecules including #PARP inhibition, CHK, AAK, WEE1. We just need to find the right predictive markers and enrich study populations. #LCSM #SLFN11 https://t.co/MJ5rWaiQQX

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Gordon Vansant @gvansant1

over 7 years ago

@JDSchonhoft of @EpicSciences presenting significance of #SLFN11 expressing #CTCs in #mCRPC , #AACR19

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Gordon Vansant @gvansant1

over 7 years ago

Mark Landers presents #SLFN11 potential predictive #Biomarker of response to DNA repair targeted therapies #enasymp

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Epic Sciences │ The Power of Clarity @EpicSciences

over 7 years ago

Will you be at #ENA2018? Come by @EpicSciences posters for new data on measuring #SLFN11 in #CTCs as a proposed #biomarker to predict response to DNA repair targeted therapies & phenotypic #heterogeneity identification in metastatic breast cancer. Details: https://t.co/cOBZmP1Wq7

EpicSciences's tweet photo. Will you be at #ENA2018? Come by @EpicSciences posters for new data on measuring #SLFN11 in #CTCs as a proposed #biomarker to predict response to DNA repair targeted therapies & phenotypic #heterogeneity identification in metastatic breast cancer. Details: https://t.co/cOBZmP1Wq7 https://t.co/Oq9u4GbEch

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