Top Tweets for #SlayerStructure
Many new questions to answer: how do things go in/out of the #Cdiff cells? How can we disrupt this armour? How does the #SlayerStructure link to function and infection? Lots to keep us busy, but for now, a huge thank you to the whole @BugS_layers team! 11/11
8. Removing the most exposed SLPL domain (D2), doesn’t change the overall SlpA structure and a functional S-layer is assembled. However, #Cdiff then becomes susceptible to lysozyme, even though the pores are still very narrow (16A). #SlayerStructure #BugSlayers 10/n
7. The #Cdiff #BugSlayer is very tightly packed, with pores of only about 11A, so only small ions can diffuse through #SlayerStructure 9/n
6. The SLPH tiles create the 2D lattice, with the SLPL covering the gaps and interlocking neighbouring molecules #SlayerStructure #BugS-layers 8/n
5. The crystal packing of SlpA mimics the assembly of the S-layer in the cells, so interactions in the crystal are a model for how the #BugSlayer assembles. #SlayerStructure 7/n
4. Using #electroncrystallography, we imaged S-layer ghosts, empty capsules of intact S-layer from the #Cdiff cells, to reconstruct a model of the assembled #BugSlayer #SlayerStructure 6/n
3. The 3D crystals are made of stacks of 2D lattices of SlpA #xraycrystallography #SlayerStructure #BugSlayer 5/n
2. the complex is maintained by an intricate “paperclip” motif by the interacting domains. #SlayerStructure #xraycrystallography #BugSlayer 4/n
Our work revealing the structure and organisation of #BugSlayer in #Cdiff is finally out in @NatComms! Huge team effort from joint 1st authors @PaolaLanzoni, @barwinskasendra, @JSamWilson, @OishikBanerji! #SlayerStructure https://t.co/sHOiuGnOqs 1/n
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