Top Tweets for #SproutingAngiogenesis
#YAP/TAZ #HydrostaticPressure #EndothelialCell
Nice characterization of Pressure (20 mmHg capillary, 55 mmHg arteriole) on 2D & 3D EC behaviors
⏫#SproutingAngiogenesis (mouse aortic ring; endothelialized microchannel in collagen hydrogel, YAP/TAZ-dependent)
⏫Proliferation
⏬Wound closure migration
⏫Motility in a confluent monolayer
⏬Barrier (2D AF488-streptavidin leaks)
⏬VE-cadherin junctional linearity, actin-junction alignment
⏫Stress fiber
⏫Partial #EndMT
⏫YAP nucleation, YAP protein abundance (in 2h😃)
Edoardo Mazza & Costanza Giampietro labs @CommsBio 2024
https://t.co/Bh2HxRpxAD
#MatrixStiffness (2->20 kPa) ⏬#SproutingAngiogenesis
A defect in maintaining a continuous endothelial sprout structure instead of a generic cell migration/invasion issue
🐭🫁explant
PEG alloc:acrylate hydrogel
Dr Lakeshia Taite lab Microcirculation 2023
https://t.co/rE39XIKynw
Nuclei-to-Cell periphery signaling in #SproutingAngiogenesis & VE-cadherin junctional dynamics
LINC complex SUN1/Nesprin1
Microtubule
GEF-H1 (RhoGEF)
Actinomyosin
VE-cad
How this is modified by #ShearStress🤓
Dr Victoria Bautch lab @eLife 2023 @vbautch1
https://t.co/t60JWt4Xeq
5-channel (separated by microposts) #Microfluidic for #EndothelialCell-#Pericyte fibrin-
collagen co-culture
👤🫁fibroblast as feeder
Enable study of Synergy b/w #ShearStress & Pericyte on #SproutingAngiogenesis😁
@Ryuji_Yokokawa lab @LabonaChip 2022
https://t.co/px9qWr6Ibf
#YAP/TAZ controls Mechanotransducive feedback Time Window in #EndothelialCell motility🤠
#MatrixStiffness-> YAP/TAZ-> Adhesion-Polarization-Migration
+🐟ISV #SproutingAngiogenesis
Dr. Amber Stratman & Joel Boerckel labs bioRxiv @StratmanLab @jboerckel
https://t.co/iXIkrg9Cl5
#Piezo1 orchestrates endothelial tip cell migration in zebrafish brain #SproutingAngiogenesis
Hi-frequency local Ca2+ transients 0.19/min -> calpain -> sprout retraction
Lo-freq 0.06/min -> eNOS -> sprout extension
Dr. Jiu-lin Du lab @NeuroCellPress 2020
https://t.co/Vd0L3sKXdP
6/
VEGFR2 is the primary signaling for #SproutingAngiogenesis, also some Intussusceptive contexts
We then blocked VEGFR2 activity with kinase inhibitor at the emergence of mother vessels. To our total surprise, we saw⏫vessel density +⏫intussussceptive pillars/splits/septa!!🤪
Rasip1, an essential mediator of #EndothelialCell #Lumenogenesis, has critical roles in proliferation, migration, junctional dynamics/stability
in #SproutingAngiogenesis & vessel anastomosis
Dr. Markus Affolter & Heinz-Georg Belting labs @Dev_journal 2021
https://t.co/SlD1QOxcmw
#EndothelialCell Non-Muscle Myosin IIA ⏫directional #SproutingAngiogenesis via ⏬excessive cortical protrusions
Spatiotemporal correlation b/w NMIIA enrichment & retraction of cortical protrusions
Dr. Xuefei Ma & Robert Adelstein labs @MBoCjournal 2020
https://t.co/CN35mlZBGr
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