Top Tweets for #MatrixStiffness
#TuberousSclerosisComplex #PulmonaryArterialHypertension
#MatrixStiffness 25 kPa (or PDGF-BB)-induced loss of TSC2 in PA #SmoothMuscleCell (not #EndothelialCell #AdventitialFibroblast)➡️
⏫mTOR & #YAP/TAZ➡️
⏫PASMC proliferation & fibrotic ECM deposit (➡️fibroblast proliferation)
SM22a+ SMC homo KO🐭of Tsc2➡️embryonic death
SM22a+ SMC het KO🐭of Tsc2➡️PAH at 9-wk (more severe in♀️)
@YuanjunS @GoncharovaLab @scisignal 2022
https://t.co/z3ohMdYw7W
#ExtraCellularMatrix #ArterialAging Sox9
#SmoothMuscleCell Sox9➡️#ExtracellularVesicle (PLOD3)➡️ECM Stiffness➡️SMC #Senescence & likely #ArterialStiffening
+A feedforward loop
Senscence+#MatrixStiffness⏫Sox9 expression & nucleation
Senescent #SmoothMuscleCell, when seeded on ECM deposited by Sox9-depleted SMCs, can be restored to Proliferative status!
Senescence▶️Loss of Anisotropy of peri-SMC matrix fibers
Sox9 immunoreactivity Not corr #VascularCalcification
A really important molecular insight of #VascularAging🤓
Catherine Shanahan lab @CircRes 2024 @iskratsch @FaleevaMaria
https://t.co/N6IxqPgRLC
#YAP #Mechanoptosis #RigiditySensing #MechanosensitiveApoptosis
pTyr357 YAP, phospho by c-Abl/Src in #FocalAdhesion then translocated to Nuclei, ➡️apoptosis of MDA-Tpm2.1 (epithelial cell) MEF (fibroblast) on soft matrix (0.25 kPa)
Cellular sensing of #MatrixStiffness dictates pro-proliferative/pro-apoptotic switch of YAP
@Haguy_Wolfenson @CellReports 2024
https://t.co/oEWON6IdML
Segregating AND Combining the impacts of Pressure (Ca2+) vs #MatrixStiffness (RhoA-LIMK) on #SmoothMuscleCell phenotypic plasticity
Converging on #Cofilin #Podosome Mechanosensing
Nice Intro to SMC #Mechanobiology🤓
@iskratsch @ScienceAdvances 2022
https://t.co/U857VEIHct
#MatrixStiffness controls hypertrophic responses of #SmoothMuscleCell to ANGII/Carbachol
12 kPa
ANGII⏬cell area, not cell volume/height (How🤔)
72 kPa
ANGII⏫cell area/volume, not height
#Piezo1-PKC-#Aquaporin1 cascade
@WarrenLabUEA @BrJPharmacol 2023
https://t.co/Gst123CZvJ
#MatrixStiffness & #PhosphatidicAcid enhance
#Senescence
#Mitochondria-ER contact
#ERStress
#MitochondriaDysfunction (JC-1)
#ROS
in #SmoothMuscleCell
Seem to be rescued by Atorvastatin (How?)🧐
#FASEBJ 2023
https://t.co/0KOGs6hVf1
#MatrixStiffness #Senescence
Passage-dependent senescent responses of cultured #CardiacFibroblast to Stiffness
Stiff hydrogel: 41 kPa
Soft: 6 kPa
Soft matrix⏫senescence (P2), ⏬TGFβ & ⏫NFκB-SASP (P5-6)
Timothy McKinsey lab @ajpheartcirc 2023
https://t.co/QCI8ucFjWu
Experiments found that transferring mouse dermal #fibroblasts from soft to stiff substrates caused an up-regulation of arginine and proline metabolism. #MatrixStiffness
Learn more in @cddpress:
➡️ https://t.co/FI1D7DWO53
Single-cell transcriptomics of #BoneMarrowMesenchymalStromalCell in response to #MatrixStiffness
2 vs 25 kPa
Adipo- vs osteogenic differentiation
TPM1/tropomyosin 1 as a Mechanotransducer upstream of #YAP
Dr. Oren Ram, Amnon Buxboim labs @PNASNews 2021
https://t.co/LVn8vX7D5P
#MatrixStiffness drives #Pericyte-to-Myofibroblast transition in a microvessel culture model
A role of #EndothelialCell Mechanosensing (Integrinβ1) + TGFβ➡️
#Angiocrine (CTGF)➡️
Fibrotic phenotype of endothelia-associated Pericyte
@atvbahajournals 2023
https://t.co/qIvkZ80HUB
Modeling the roles of #MatrixStiffness & Cell Aspect Ratio in cell re-orientation to #CyclicStretch
"on soft substrates, round-like cells more likely orient themselves in a parallel/perpendicular fashion"
Dr. Luigi Preziosi lab Bull Math Biol 2023
https://t.co/f5QREE8j6D
Landmark revisit
#Pericyte #Alveologenesis
#MatrixStiffness #YAP/TAZ-induced expression of HGF+Angpt1 in PDGFRβ+🫁pericyte⏫postnatal🫁#Angiogenesis #Alveologenesis
Postnatal Y/T KO doesn't impact🫁pericyte, ACTA2+ density
@ralfhadams @NatureComms 2019
https://t.co/WpxwuMwrNK
#MatrixStiffness (2->20 kPa) ⏬#SproutingAngiogenesis
A defect in maintaining a continuous endothelial sprout structure instead of a generic cell migration/invasion issue
🐭🫁explant
PEG alloc:acrylate hydrogel
Dr Lakeshia Taite lab Microcirculation 2023
https://t.co/rE39XIKynw
#MatrixStiffness (4 vs 11 kPa) of GelMA #Hydrogel Substrate regulates👤Lung Fibroblast
Proliferation
Cytoskeleton
Matrix deposition (Decorin/Collagen/Microfibril)
Secretome (IL6)
Fig 4↔️6?🧐
Dr. Janette Burgess lab @FrontPharmacol 2022 @JanetteKBurgess
https://t.co/b1UQUUZypu
Geometry (+#MatrixStiffness) determines #EndothelialCell collective behaviors/Morphogenesis😎
"Balance between Cell Tension, Adhesion, and Cohesion Can Explain the Observed Cell Organization"
Dr. Lewis Romer & David Gracias labs Adv Sci 2022 @AdvSciNews
https://t.co/SiOGU85SE6
#YAP/TAZ controls Mechanotransducive feedback Time Window in #EndothelialCell motility🤠
#MatrixStiffness-> YAP/TAZ-> Adhesion-Polarization-Migration
+🐟ISV #SproutingAngiogenesis
Dr. Amber Stratman & Joel Boerckel labs bioRxiv @StratmanLab @jboerckel
https://t.co/iXIkrg9Cl5
DDR1 as mechano-chemical sensor for #MatrixStiffness & Collagen to activate #YAP/TAZ in #SmoothMuscleCell
& YAP/TAZ transcribe DDR1
Fascinating DDR1-YAP/TAZ loop in vascular disorders to explore🤠
Dr Michelle Bendeck lab @BendeckBendeck Matrix Biol 2022
https://t.co/V9dE2nln4f
Collaborators at @QMULSEMS and @HKUniversity studied the impact of #MatrixStiffness and pressure on vascular smooth muscle cells with implications in #AtheroscleroticDisease progression.
Full article in @ScienceAdvances:
📝: https://t.co/IRwDeTJUzu
New in @MolTherapy! 💡
Researchers identified the key enzyme that responded to #MatrixStiffness and regulated lipid metabolism in #HepatocellularCarcinoma cells.
Read their findings: 🔗 https://t.co/TxQLEwfyA0
#YAP as a #MatrixStiffness mechanotransducer of #LaminaCribrosa fibroblast-like cells -> proliferation & fibrogenesis
The sieve-like LC of optic nerve head, sheathing RGC axon, senses intraocular pressure in #Glaucoma
Dr. Colm O’Brien lab @ARVOiovs 2022
https://t.co/wvNLPr30PR
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