Top Tweets for #Systemicsclerosis
Mitochondrial dysfunction continues to emerge as a key player in #SystemicSclerosis. This study provides mechanistic evidence linking mitochondrial Ca²⁺ overload to mtDNA leakage, cGAS-STING activation, and fibrosis, while highlighting circulating mtDNA as a potential biomarker of disease severity. An exciting avenue for future therapeutic development. #Rheumatology
Findings from a study of 50 patients with systemic sclerosis showed mitochondrial Ca2+ overload drives mtDNA leakage and activates cGAS-STING signaling, promoting fibroblast activation and skin fibrosis. Plasma mtDNA also correlated with disease severity, highlighting a potential biomarker and therapeutic target
A&R
https://t.co/3xvfEugVJo
Image: Illustration of the proposed mechanism of mitochondrial DNA on promoting skin fibrosis in systemic sclerosis
Paul is fundraising for systemic sclerosis research after his wife was diagnosed with the disease. Support the NVLE Fund and help move better treatments closer.
Donate or share today:
https://t.co/5y50w8H4uR
#SystemicSclerosis #MedicalResearch g #WhyDonate
Scleroderma: Causes, Symptoms, and Holistic Management
Scleroderma is most commonly known as Systemic Sclerosis (or SSc) when it affects the whole body. Other names for the condition include... Read more: https://t.co/sG6E5Lc86G #SS #scleroderma #Systemicsclerosis #holistic
July is here! 🌻
Catch up on the latest research, reviews, and clinical insights from @Jrheum.
📘 https://t.co/VpHu6bWH7V
#PsoriaticArthritis #Biologics #Lupus #SjögrenDisease #SystemicSclerosis #Myositis #Osteoarthritis #StillDisease
Has anyone with #InterstitialLungDisease (ILD) and #SystemicSclerosis (Scleroderma) received #Imdelltra (#Tarlatamab) for relapsed #SmallCellLungCancer?
My dad (PS0) is to get Imdelltra. I’m researching the risks but haven’t been able to find any case like above
#SCLC #LungCancer
A study in the journal Rheumatology found the SPIN pain assessment tool includes critical information on pain sources important to people with #SystemicSclerosis (#SSc). It provides a useful tool to study the epidemiology of the complex pain experience in SSc, including pain sources and how pain is experienced.
Read more here: https://t.co/3xcpZpB214
#SclerodermaAwarenessMonth 🌻
'Living with a rare disease without a cure, is most character building that's for sure'.
https://t.co/FwgC5NDvgj
https://t.co/AmyGYQplrK
#SclerodermaFreeWorld #RaynaudsFreeWorld #BePartOfResearch #SystemicSclerosis #Raynauds #RareDisease #NoCure
@arthritisukorg Thank You for investing in medical research into #scleroderma #SystemicSclerosis #SclerodermaFreeWorld #BePartOfResearch #NoCure #LifeChanging #ConnectiveTissue
🌍 On #WorldSclerodermaDay, #EUSTAR stands with everyone affected by #SystemicSclerosis.
🎯Together with patients, clinicians, researchers, and healthcare professionals, we're working to improve outcomes and advance the future of SSc care💙
#Scleroderma #EUSTAR #RareDisease
Happy #WorldSclerodermaDay 29th June 🌻#SclerodermaAwarenessMonth
Why 29th June? https://t.co/9qQSzzvXx1
Leave a gift in your Will:
https://t.co/vd8wz8p1G7
#SclerodermaFreeWorld #RaynaudsFreeWorld #BePartOfResearch #Scleroderma #SystemicSclerosis #NoCure #LifeChanging #Raynauds
🌍 World Scleroderma Awareness Day 2026
Theme: “#HearTheUnheard”
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Every year on June 29, the world observes World Scleroderma Awareness Day to shine a light on scleroderma (#SystemicSclerosis)—a rare, chronic autoimmune connective tissue disease that is often misunderstood and diagnosed late. The 2026 theme, “Hear the Unheard,” calls upon healthcare professionals, policymakers, researchers, and society to listen to the voices of patients whose struggles frequently remain invisible. (Stichting Scleroderma Framed)
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#Scleroderma occurs when the immune system becomes overactive, triggering excessive production of collagen. This abnormal collagen deposition causes hardening and thickening of the skin and may also damage vital organs including the lungs, heart, kidneys, gastrointestinal tract, and blood vessels.
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The exact cause remains unknown, but genetic susceptibility, environmental triggers, and immune dysregulation are believed to play important roles. Women are affected far more commonly than men.
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Common symptoms include Raynaud’s phenomenon (fingers turning white or blue in cold), skin tightening, swollen fingers, joint pain, acid reflux, difficulty swallowing, breathlessness, fatigue, and digital ulcers. Early recognition is crucial because organ involvement can be life-threatening.
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Although there is no definitive cure, remarkable advances have improved outcomes. Treatment focuses on controlling immune activity with immunosuppressive drugs, managing symptoms, preventing complications, and preserving organ function through a multidisciplinary approach involving rheumatologists, pulmonologists, cardiologists, dermatologists, and rehabilitation specialists.
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One of the most well-known personalities believed to have suffered from systemic sclerosis was the celebrated Swiss-born artist Paul Klee, whose memory is honoured on
#WorldSclerodermaDay.
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Let us hear the unheard, support early diagnosis, promote research, and stand with every person living with scleroderma—because awareness can change lives. 💙
#RareDisease #AutoimmuneDisease #EarlyDiagnosis #MedEd #MedX #HealthAwareness #MedicalEducation #PatientSupport #MedTwitter
: @WHO @WHOSouthEastAsia @UN @NIH @CDCGov @ACRheum @sowmiyasid @IhabFathiSulima @ajaykraina @AnujaJaiswalTOI
@hyderabaddoctor
#SclerodermaAwarenessMonth 🌻
PERSONAL EXPERIENCE/ SURVIVAL TIPS Infographic
'Living with a rare disease without a cure, is most character building, that's for sure' https://t.co/VM3NPbFnHn #SclerodermaFreeWorld #BePartOfResearch #SystemicSclerosis #Raynauds #NoCure #LifeChanging
Carrie L. Richardson, MD, contributed to a study that sought to determine the long-term outcomes of reduced-intensity conditioning autologous hematopoietic #StemCellTransplantation in patients with #SystemicSclerosis (#SSc) and cardiac involvement.
Find out more: https://t.co/vrUh5AXFdK
#SclerodermaAwarenessMonth 🌻
This infographic highlights sclerodactyly hands and the subsequent #disability. Stiff, fragile fingers covered by tight skin. Sadly, I have to bandage my fingers
https://t.co/Ufhq5VsJfg
#SclerodermaFreeWorld #BePartOfResearch #SystemicSclerosis
#SclerodermaAwarenessMonth 🌻
ORAL / DENTAL involvement. Dry mouth combined with gum recession, and bone reabsorption, cause tooth loss.
https://t.co/64oYQG641M
#SclerodermaFreeWorld #RaynaudsFreeWorld #BePartOfResearch #Scleroderma #SystemicSclerosis #Raynauds #NoCure
#SclerodermaAwarenessMonth 🌻
TELANGIECTASIA Unmet Clinical Need Infographic
https://t.co/aNxQfLyiQS
#SclerodermaFreeWorld #RaynaudsFreeWorld #BePartOfResearch #Scleroderma #SystemicSclerosis #Raynauds #Autoimmune #RareDisease #NoCure #UnknownCause #LifeChanging #ConnectiveTissue
🎙️ #EULAR2026 Interview | Dr Maria Iacovantuono speaks with Andrea-Hermina Györfi on primary heart involvement in #SystemicSclerosis and the use of iPSC-derived cardiac microtissues as innovative platforms for disease modelling and drug testing 🫀 https://t.co/1M6KC61BJF
Delighted that https://t.co/VM3NPbFnHn has over a million views 🥳 #SclerodermaAwarenessMonth 🌻
I started the blog 10 years ago
#SclerodermaFreeWorld #RaynaudsFreeWorld #BePartOfResearch #Scleroderma #SystemicSclerosis #Raynauds #RareDisease #NoCure #UnknownCause #LifeChanging
#SclerodermaAwarenessMonth 🌻
MOBILITY https://t.co/LSdKNPbG6g
I am the real life tin man:
https://t.co/1RMhQe0yoF
https://t.co/IXveYSKFfm
#SclerodermaFreeWorld #RaynaudsFreeWorld #BePartOfResearch #SystemicSclerosis #Raynauds #Autoimmune #RareDisease #NoCure #UnknownCause
LUNG / PULMONARY Infographic
Thank You to fellow @RoyalFreeNHS patient, Alexandra, for sharing her lung x-ray
https://t.co/jXOGp5KbtX 🌻
#SclerodermaFreeWorld #RaynaudsFreeWorld #BePartOfResearch #NoCure #PAH #ILD #SystemicSclerosis #Raynauds #RareDisease #Autoimmune #Fibrosis
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