Top Tweets for #THERAP
Yogathan | Yoga Day | International | Flute 🪈 #music #meditation #therap... https://t.co/KRIjne3qEs via @YouTube
Wonderful talk by @drlouiseemmett in #ASCO26 educational session on “How to Better Personalize Treatment With Lu-PSMA,” highlighting the amazing clinical and translational outcomes of many studies especially @ANZUPtrials #TheraP and #ENZAp. These great trials continue to deliver.
ctDNA biomarkers in #TheraP trial: Cabazitaxel vs lutetium-PSMA comparison. @ResearchWyatt @VanProstateCtr joins Oliver Sartor, MD @EJHospital in this discussion, emphasizing the context-dependent nature of biomarkers across treatment lines and highlighting future directions, including epigenomic factors in radioresistance. #WatchNow > https://t.co/WpLgBkxaKM
ctDNA biomarkers in #TheraP trial: Cabazitaxel vs lutetium-PSMA comparison. @ResearchWyatt @VanProstateCtr joins Oliver Sartor, MD @EJHospital in this discussion, emphasizing the context-dependent nature of biomarkers across treatment lines and highlighting future directions, including epigenomic factors in radioresistance. #WatchNow > https://t.co/WpLgBkxaKM
ctDNA biomarkers in #TheraP trial: Cabazitaxel vs lutetium-PSMA comparison. @ResearchWyatt @VanProstateCtr joins Oliver Sartor, MD @EJHospital in this discussion, emphasizing the context-dependent nature of biomarkers across treatment lines and highlighting future directions, including epigenomic factors in radioresistance. #WatchNow > https://t.co/WpLgBkxaKM
PCPro as a prognostic plasma lipidomic biomarker in #TheraP (ANZUP 1603): a randomized trial of 177Lu-PSMA-617 vs cabazitaxel in #mCRPC. Presentation by Tahlia Scheinberg, MD @Sydney_Uni. #ESMO25 written coverage by @zklaassen_md @GACancerCenter > https://t.co/DiSQ3F5x86 @myESMO @neerajaiims
ctDNA biomarkers in #TheraP trial: Cabazitaxel vs lutetium-PSMA comparison. @ResearchWyatt @VanProstateCtr joins Oliver Sartor, MD @EJHospital in this discussion, emphasizing the context-dependent nature of biomarkers across treatment lines and highlighting future directions, including epigenomic factors in radioresistance. #WatchNow > https://t.co/WpLgBkxaKM
This review summarizes the pathological mechanisms and therapeutic strategies for erectile dysfunction, encompassing lifestyle, pharmacological, physical, stem cell, and surgical approaches.
#IJDDP #ED #pathophysiology #therap #TIA2025
https://t.co/JlLH7LftSe
ctDNA biomarkers in #TheraP trial: Cabazitaxel vs lutetium-PSMA comparison. @ResearchWyatt @VanProstateCtr joins Oliver Sartor, MD @EJHospital in this discussion, emphasizing the context-dependent nature of biomarkers across treatment lines and highlighting future directions, including epigenomic factors in radioresistance. #WatchNow > https://t.co/WpLgBkxaKM
Correlative work is possibly our most important tool in clinical trials. Congrats to @EdmondMKwan & #TheraP team for this insightful pub on ctDNA burden & PTEN loss predicting responses to 177Lu-PSMA & reminding us of his why - the patients behind the data. @ANZUPtrials #ANZUP25
Some #ASCO25 highlights from @ASCOPost including @ANZUPtrials studies #EVOLUTION, #TheraP & #BCGMM @CancerAustralia @Prof_IanD
🚨Just weeks after #ASCO25, the latest highlights in genitourinary cancers are now available. The newly released @ASCOPost provides a quick and concise overview.
👀Take another look, this time from our perspective w/ @DrYukselUrun
👉https://t.co/1doMidEpwT
@ASCO @jamecancerdoc @OncoAlert
#ProstateCancer #BladderCancer #KidneyCancer #Cancer #Oncology #MedX
Congratulations to @EdmondMKwan who was a finalist in the 2024/25 Victorian Premier’s Awards for Health & Medical Research - Clinical Researcher Award category for his ctDNA research work into the @ANZUPtrials #TheraP trial https://t.co/Vdalxu57N7
Congrats @ANZUPTrials #TheraP study presented #ASCO25 by Dr Aslı Munzur. Thanks to @PCFnews @bccancerfdn @TerryFoxCanada #CanadianCancerSociety @PeterMacCC @pros_tic @VanProstateCtr @VCHResearch @UBC @PCFA @MovemberAUS @ANSTO @adacap_news @TrialsCentre @gentlemansride @Novartis
Clonal hematopoiesis (CH) in the @ANZUPtrials #TheraP study @ASCO #ASCO25 presented by Asli Munzur
■ ¹⁷⁷Lu-PSMA-617: higher incidence of emergent CH compared to cabazitaxel chemotherapy
■ Most new clonal hematopoiesis mutations ¹⁷⁷Lu-PSMA-617 fall in DNA damage repair response genes PPM1D, TP53, ATM, and CHEK2.
■ Clinical significance unclear but may become more relevant as radioligand therapy moves into earlier lines of treatment
@ResearchWyatt @AzadOncology
🗣️Prostate Rapid Oral Abstract #ASCO25
👉Abst5020: Dr #AslıDoğaMunzur presenting #ClonalHematapoesis a/w LuPSMA617 on #TheraP
🔑 KEY TAKE AWAYS
- #LuPSMA617 a/w greater number of new #CHmutations in DDR genes vs cabazitaxel.
- CH emergence and expansion may have implications as RLTs used as an earlier line of therapy.
👥@neerajaiims @Silke_Gillessen @APCCC_Lugano @Prof_Nick_James @CParkMD @ChrisSweens1 @AtishChoudhury @TDorffOnc @xiaoweimd @CaPsurvivorship @drenriquegrande @bavilima @DRBakaloudiMD @nataliagandur @bergsa83 @PrafulRavi1 @Lachelle_Dawn @OncBrothers @urotoday @Uromigos
Clonal hematopoiesis (CH) in the @ANZUPtrials #TheraP study @ASCO #ASCO25 presented by Asli Munzur
■ ¹⁷⁷Lu-PSMA-617: higher incidence of emergent CH compared to cabazitaxel chemotherapy
■ Most new clonal hematopoiesis mutations ¹⁷⁷Lu-PSMA-617 fall in DNA damage repair response genes PPM1D, TP53, ATM, and CHEK2.
■ Clinical significance unclear but may become more relevant as radioligand therapy moves into earlier lines of treatment
@ResearchWyatt @AzadOncology
@EdmondMKwan @ANZUPtrials @NatureMedicine @PCF_Science @ResearchWyatt @mishabeltran @DrMHofman @AzadOncology @AnthonyMJoshua @MartinStockler @ButeauJames @ReneaTaylor1 Amazing work @EdmondMKwan and team, well done!
@ANZUPtrials @easternhealthau @Monash_FMNHS @MonashBDI @EHCSMonash @ResearchWyatt @AzadOncology @DrMHofman @VanProstateCtr @PCF_Science @pcfa #ASCO25 #TheraP #ProstateCancer #pcsm
https://t.co/ZEWbXJx2Gd
The #TheraP study started life at an @ANZUPtrials IGW in 2016 !! It evolved into the first randomised trial of Lu-177 PSMA-617. Thanks @Prof_IanD and the incredible team that made it happen...
https://t.co/b6mXrcd2r9
The 2025 @ANZUPTrials Idea Generation Workshop series continues today with the Germ Cell Workshop led by @DrBenTran and @ciaraconduit held @PeterMacCC. Our IGWs are where many of the seeds for ANZUP #clinicaltrials are first sown #ANZUPconcepts @CancerAustralia @Prof_IanD
LuCab Clinical Trial protocol now online @JournalofNucMed
@ANZUPtrials #TheraP assessed Lu-177 PSMA-617 versus cabazitaxel
LuCab assesses Lu-177 PSMA-617 in combination with cabazitaxel
https://t.co/m6zHgG73dZ
Congrats @LouiseKostos, our medical oncology PhD leading this study together @ButeauJames, @AzadOncology and team @pros_tic @PeterMacCC
Supported by @PCF_Science
Hot of the press in @JournalofNucMed ... with 10 years experience in Lutetium-177 PSMA radioligand therapy we describe a 1.3% incidence of myelodysplasia.
We deep dive on each case with remarkable findings. One patient who participated in the @ANZUPtrials #TheraP trial had blood frozen prior to treatment. Analysis by @ResearchWyatt @EdmondMKwan identified a specific "at-risk" mutation that was present prior to Lu-PSMA.
https://t.co/ayXMkrwtGi
Shout-out to first author @pros_tic fellow Dr Michal Eifer @sheba_medical and co-authors @ButeauJames @AzadOncology @drlouiseemmett @LouiseKostos @liz_medhurst @SandhuShahneen
@PCF_Science
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