Top Tweets for #Urate

4 months ago

𝗔𝗹𝗹𝗼𝗽𝘂𝗿𝗶𝗻𝗼𝗹 ◦ According to 2016 updated EULAR evidence-based recommendations for the management of #gout, in patients with normal kidney function, #allopurinol is recommended for first-line #urate-lowering therapy, starting at a low dose (100 mg/day) and increasing by 100 mg increments every 2–4 weeks if required up to the maximum allowed dosage (600-800 mg/d), to reach the uricemic target (serum uric acid levels <6 mg/dL, in case of tophaceous gout <5 mg/dL). ◦ If the serum uric acid target cannot be reached by an appropriate dose of allopurinol, it should be switched to #febuxostat 80 mg/d (can be increased up to 120 mg/d) or a #uricosuric, or combined with a uricosuric. ◦ Febuxostat or a uricosuric are also indicated if allopurinol cannot be tolerated. ◦ Alternative treatments in refractory cases: - Probenecid 250 mg (one-half of a 500-mg tablet) two times a day for about one week, then 500 mg (one tablet) two times a day for a few weeks - Lesinurad 200 mg once a day in the morning (maximum dose) - Pegloticase 8 mg via IV infusion every 2 weeks *Richette P, Doherty M, Pascual E, et al. 2016 updated EULAR evidence-based recommendations for the management of gout. Ann Rheum Dis. 2017;76(1):29-42. 🔗https://t.co/wXB73ZeFyY

$alb_giraldo's tweet photo. 𝗔𝗹𝗹𝗼𝗽𝘂𝗿𝗶𝗻𝗼𝗹 ◦ According to 2016 updated EULAR evidence-based recommendations for the management of #gout, in patients with normal kidney function, #allopurinol is recommended for first-line #urate-lowering therapy, starting at a low dose (100 mg/day) and increasing by 100 mg increments every 2–4 weeks if required up to the maximum allowed dosage (600-800 mg/d), to reach the uricemic target (serum uric acid levels <6 mg/dL, in case of tophaceous gout <5 mg/dL). ◦ If the serum uric acid target cannot be reached by an appropriate dose of allopurinol, it should be switched to #febuxostat 80 mg/d (can be increased up to 120 mg/d) or a #uricosuric, or combined with a uricosuric. ◦ Febuxostat or a uricosuric are also indicated if allopurinol cannot be tolerated. ◦ Alternative treatments in refractory cases: - Probenecid 250 mg (one-half of a 500-mg tablet) two times a day for about one week, then 500 mg (one tablet) two times a day for a few weeks - Lesinurad 200 mg once a day in the morning (maximum dose) - Pegloticase 8 mg via IV infusion every 2 weeks *Richette P, Doherty M, Pascual E, et al. 2016 updated EULAR evidence-based recommendations for the management of gout. Ann Rheum Dis. 2017;76(1):29-42. 🔗https://t.co/wXB73ZeFyY$

Dr. August Bones

@Ausbones

4 months ago

What is the first-line long-term uric acid-lowering therapy for chronic gout?

6 months ago

#Gout is increasingly recognized as an #autoinflammatory disease driven by #NLRP3 #inflammasome activation, rather than solely a metabolic disorder of elevated serum #urate (SU). Traditional treatments like NSAIDs, glucocorticoids, and colchicine are non-specific, while direct IL-1β inhibitors (e.g., canakinumab and anakinra) offer more targeted options for acute flares, particularly in patients with contraindications or poor response to standard therapies. Canakinumab has shown superior efficacy over anakinra, likely due to differences in mechanism and half-life. Emerging therapies focus on NLRP3 inflammasome inhibition, including small-molecule inhibitors like dapansutrile and natural compounds (procyanidin B2, cherry anthocyanins). Notably, existing drugs such as probenecid, allopurinol, and colchicine also exhibit anti-NLRP3 effects through various mechanisms (e.g., microtubule disruption by colchicine). This shift toward viewing gout as a sterile autoinflammatory condition triggered by monosodium urate (MSU) crystals as DAMPs opens new avenues for precision treatments beyond urate-lowering therapy alone. *From: Schlesinger N, Kaufmann D. Is gout an autoinflammatory disease? Curr Rheumatol Rep. 2026;28(1):9. 🔗https://t.co/pZ3rxslGYN

alb_giraldo's tweet photo. #Gout is increasingly recognized as an #autoinflammatory disease driven by #NLRP3 #inflammasome activation, rather than solely a metabolic disorder of elevated serum #urate (SU). Traditional treatments like NSAIDs, glucocorticoids, and colchicine are non-specific, while direct IL-1β inhibitors (e.g., canakinumab and anakinra) offer more targeted options for acute flares, particularly in patients with contraindications or poor response to standard therapies. Canakinumab has shown superior efficacy over anakinra, likely due to differences in mechanism and half-life.

Emerging therapies focus on NLRP3 inflammasome inhibition, including small-molecule inhibitors like dapansutrile and natural compounds (procyanidin B2, cherry anthocyanins). Notably, existing drugs such as probenecid, allopurinol, and colchicine also exhibit anti-NLRP3 effects through various mechanisms (e.g., microtubule disruption by colchicine).

This shift toward viewing gout as a sterile autoinflammatory condition triggered by monosodium urate (MSU) crystals as DAMPs opens new avenues for precision treatments beyond urate-lowering therapy alone.

*From: Schlesinger N, Kaufmann D. Is gout an autoinflammatory disease? Curr Rheumatol Rep. 2026;28(1):9.
🔗https://t.co/pZ3rxslGYN

6 months ago

🔓Biological Therapies for Urate Lowering and Inflammation Control in Gout Management #urate #gout #D2T https://t.co/uFllrw9ifZ

299

6 months ago

🔓Reduced Serum Urate Concentrations Despite Unchanged Allopurinol Dosing in Gout Patients Commenced on Dialysis: A Retrospective Chart Review #kidney #urate #gout #CKD https://t.co/i5n3PSOD5Z

330

6 months ago

🇪🇸🇫🇷🇪🇺 European Crystal Network Workshop Paris 2026 #urate #gout #calcium #CPPD #crystals @geacser

239

The Journal of Rheumatology @jrheum

7 months ago

📑🫀 Unseen but Impactful: Gout as a Neglected Comorbidity in Cardiovascular Care #gout #urate #cardiovascular https://t.co/iberrq37Rs

113

8 months ago

Research Article Do Monosodium Urate Crystals Reduce at Different Rates in Joints and Tendons During Urate-Lowering Therapy? A Dual-Energy Computed Tomography Study 📖 https://t.co/mtgxZrSMKO @AucklandUni #Gout #Tendon #Urate

jrheum's tweet photo. Research Article

Do Monosodium Urate Crystals Reduce at Different Rates in Joints and Tendons During Urate-Lowering Therapy? A Dual-Energy Computed Tomography Study

📖 https://t.co/mtgxZrSMKO
@AucklandUni

#Gout #Tendon #Urate https://t.co/Til2ixH9EB

338

The Journal of Rheumatology @jrheum

8 months ago

Editorial The Reversibility of Urate Tophi With Treat-to-Target in Gout: All Gone. Forever? 📖 https://t.co/SA5mOQR6GQ @bcmhouston @UABDeptMed @DoctorJasvinder #Gout #Tendon #Urate

jrheum's tweet photo. Editorial

The Reversibility of Urate Tophi With Treat-to-Target in Gout: All Gone. Forever?

📖 https://t.co/SA5mOQR6GQ
@bcmhouston @UABDeptMed @DoctorJasvinder

#Gout #Tendon #Urate https://t.co/doFnrCzHCT

423

SABOURETCardiologist @SABOURETCardio

8 months ago

#Correlation or #Causation ? #Urate

JAMA Internal Medicine @JAMAInternalMed

8 months ago

Among patients with #Gout, achieving serum urate <6 mg/dL with urate-lowering therapy was associated with lower 5-year risk of major adverse cardiovascular events, especially for those at high cardiovascular risk. https://t.co/wT1mgVDffc

JAMAInternalMed's tweet photo. Among patients with #Gout, achieving serum urate <6 mg/dL with urate-lowering therapy was associated with lower 5-year risk of major adverse cardiovascular events, especially for those at high cardiovascular risk.

https://t.co/wT1mgVDffc https://t.co/IQoEpM7vLs

8 months ago

Treat-to-Target Urate-Lowering Treatment and Cardiovascular Outcomes in Patients With Gout #gout #urate #T2T #GoFor6 #cardiovascular @geacser https://t.co/F8Df0825uJ

210

10 months ago

📑Febuxostat effectively and safely reduces serum urate in gout patients with chronic kidney disease: A prospective multicenter ULTRA registry study #urate #gout #kidney #CKD https://t.co/zLWBkYo1fe

176

10 months ago

Ultrasound-detected crystal depositions and clinical flares dissolve during successful urate-lowering therapy: 5-year follow-up results from the treat-to-target NOR-Gout study #urate #gout #ultrasound https://t.co/NFFo4GfwGH

636

Dr.Haitham Hamoud | د.هيثم

10 months ago

𝗧𝗼𝗽𝗵𝗮𝗰𝗲𝗼𝘂𝘀 𝗴𝗼𝘂𝘁 ◦ The photographs show the pre- and post-operative resection of #gout #tophus out of the third finger (#tophectomy). ◦ Tophaceous gout is a chronic form of gout characterized by nodular masses of monosodium #urate crystals (#tophi) surrounded by soft tissue that contains macrophages and other immune cells. ◦ Tophi are most commonly found as hard nodules around the fingers, elbows, big toes and ears, but they may appear anywhere in the body. ◦ Periarticular tophi may lead joint instability or severe limitation of motion impairing function. In addition to cosmetic concerns, other complications of tophaceous gout include infection, ulceration, drainage, and entrapment neuropathy. ◦ The objective of urate-lowering therapy in tophaceous gout, according to EULAR's recommendations, is to maintain the urate levels below 5 mg/dl. The pharmacological treatment alternatives are: - First-line treatments: • #Allopurinol 100 mg/d, adapting the dosage to the kidney function. Slow titration up to the maximum allowed dosage (600-800 mg/d). • #Febuxostat 80 mg/d, can be increased up to 120 mg/d. - Alternative treatments in refractory cases: • #Probenecid 250 mg (one-half of a 500-mg tablet) two times a day for about one week, then 500 mg (one tablet) two times a day for a few weeks. • #Lesinurad 200 mg once a day in the morning (maximum dose). • #Pegloticase 8 mg via IV infusion every 2 weeks. ◦ Surgical treatment for tophi through procedures like excision, suction, or debridement, is considered when they cause severe pain, deformity, nerve compression, or infection, especially when medical treatments are insufficient.

$alb_giraldo's tweet photo. 𝗧𝗼𝗽𝗵𝗮𝗰𝗲𝗼𝘂𝘀 𝗴𝗼𝘂𝘁 ◦ The photographs show the pre- and post-operative resection of #gout #tophus out of the third finger (#tophectomy). ◦ Tophaceous gout is a chronic form of gout characterized by nodular masses of monosodium #urate crystals (#tophi) surrounded by soft tissue that contains macrophages and other immune cells. ◦ Tophi are most commonly found as hard nodules around the fingers, elbows, big toes and ears, but they may appear anywhere in the body. ◦ Periarticular tophi may lead joint instability or severe limitation of motion impairing function. In addition to cosmetic concerns, other complications of tophaceous gout include infection, ulceration, drainage, and entrapment neuropathy. ◦ The objective of urate-lowering therapy in tophaceous gout, according to EULAR's recommendations, is to maintain the urate levels below 5 mg/dl. The pharmacological treatment alternatives are: - First-line treatments: • #Allopurinol 100 mg/d, adapting the dosage to the kidney function. Slow titration up to the maximum allowed dosage (600-800 mg/d). • #Febuxostat 80 mg/d, can be increased up to 120 mg/d. - Alternative treatments in refractory cases: • #Probenecid 250 mg (one-half of a 500-mg tablet) two times a day for about one week, then 500 mg (one tablet) two times a day for a few weeks. • #Lesinurad 200 mg once a day in the morning (maximum dose). • #Pegloticase 8 mg via IV infusion every 2 weeks. ◦ Surgical treatment for tophi through procedures like excision, suction, or debridement, is considered when they cause severe pain, deformity, nerve compression, or infection, especially when medical treatments are insufficient.$

@hemo_shk

10 months ago

#GT B&A What is the diagnosis? #MedX #MEDHM @IhabFathiSulima

207

43K

337

10 months ago

Response to allopurinol and febuxostat according to the fractional excretion of urate in men with gout - Richette - Arthritis Care & Research - Wiley Online Library #gout #urate #kidney ⁦@geacser⁩ https://t.co/FuzAPQUOPB

188

عقيًل بن محمد العقيًل( أبو أنس)

11 months ago

🔬Length of Monosodium Urate Crystals in Synovial Fluid Based on Ultrasound Articular Deposits: Advancements in Crystallization Process #gout #uric #urate #crystals @geacser 🇪🇸 https://t.co/H64btFm2km #mdpigucdd a través de @GUCDD_MDPI

251

@akiluno_a

11 months ago

ماهو سبب #ألم_المفاصل عند المرضى الذين لديهم إلتهاب المسالك البولية؟ بسبب حامض اليوريك #uric_acid الناتج من تكسر البروتين (اللحوم الحمراء وغيرها) فعندما لاتستطيع الكلية #kidney طرحة مع الإدرار لوجود خلل ما يتحول إلى #urate يترسب على المفاصل و يسبب إلتهاب المفاصل وتورم خصوصا في الأقدام. لذلك يجب علاج إلتهاب الكلية حتى تستطيع طرحه إلى الخارج مع التقليل من اللحوم الحمراء.

akiluno_a's tweet photo. ماهو سبب #ألم_المفاصل عند المرضى الذين لديهم إلتهاب المسالك البولية؟

بسبب حامض اليوريك #uric_acid
الناتج من تكسر البروتين (اللحوم الحمراء وغيرها)
فعندما لاتستطيع الكلية #kidney طرحة مع الإدرار لوجود خلل ما يتحول إلى #urate يترسب على المفاصل و يسبب
إلتهاب المفاصل وتورم خصوصا في الأقدام.
لذلك يجب علاج إلتهاب الكلية حتى تستطيع طرحه إلى الخارج مع التقليل من اللحوم الحمراء.

about 1 year ago

Treatment with the oral glucagon-like peptide-1 receptor agonist #semaglutide is associated with a modest but statistically significant reduction in serum #urate (SU) levels in type 2 #diabetes patients, as demonstrates the Spanish retrospective real-world analysis study URISEMA: ◦ Under oral semaglutide, 70.7 % and 76 % showed SU <6 mg/dL at 6 and 12 months, respectively. ◦ Higher baseline SU and switching from a DPP-4 inhibitor were independently associated with achieving the therapeutic SU goal. ◦ The decrease in SU did not correlate with changes in weight or HbA1c. These results provide novel evidence for a modulatory effect of oral semaglutide on SU metabolism in type 2 diabetes patients. *Moreno-Pérez O, Tejera-Muñoz A, Carreño-Valdivia R, et al. Impact of oral semaglutide on serum urate levels in people with type 2 diabetes: A retrospective real-world analysis (URISEMA study). Semin Arthritis Rheum. Semin Arthritis Rheum. 2025 Aug 7;74:152807. 🔗https://t.co/ohtj5ux27u

alb_giraldo's tweet photo. Treatment with the oral glucagon-like peptide-1 receptor agonist #semaglutide is associated with a modest but statistically significant reduction in serum #urate (SU) levels in type 2 #diabetes patients, as demonstrates the Spanish retrospective real-world analysis study URISEMA:
◦ Under oral semaglutide, 70.7 % and 76 % showed SU <6 mg/dL at 6 and 12 months, respectively.
◦ Higher baseline SU and switching from a DPP-4 inhibitor were independently associated with achieving the therapeutic SU goal.
◦ The decrease in SU did not correlate with changes in weight or HbA1c.

These results provide novel evidence for a modulatory effect of oral semaglutide on SU metabolism in type 2 diabetes patients.

*Moreno-Pérez O, Tejera-Muñoz A, Carreño-Valdivia R, et al. Impact of oral semaglutide on serum urate levels in people with type 2 diabetes: A retrospective real-world analysis (URISEMA study). Semin Arthritis Rheum. Semin Arthritis Rheum. 2025 Aug 7;74:152807.
🔗https://t.co/ohtj5ux27u

252

Janet Pope @Janetbirdope

over 1 year ago

T2T in #gout w serum #uric #acid / #urate target SAVES LIVES Study of achievement of target 🎯 ⬇️CVE and death If not achieving Urate <360 T2T also reduced baseline #SUA #EULAR2025 @rheumnow abst#OP0005

Janetbirdope's tweet photo. T2T in #gout w serum #uric #acid / #urate target

SAVES LIVES

Study of achievement of target 🎯
⬇️CVE and death

If not achieving Urate <360
T2T also reduced baseline #SUA

#EULAR2025 @rheumnow abst#OP0005 https://t.co/ePchJ4vqnU