Top Tweets for #augmin
Nice to see our paper out in @J_Cell_Sci on how #gTuRCs and #Augmin are important for the development of highly-branched class IV da #neurons in #Drosophila.
https://t.co/1iuNhalrin
Is there a better way to celebrate a first first-author paper than with a nice chocolate cake? The long #augmin journey shared with @isabella__k in @Toliclab, filled with many challenges, fun microscope sessions and discussions with pancakes, is now published in @eLife! ๐ฅณ
Hot off the press in @eLife! @Stimac_V and @isabella__k pushed the limits of super-resolution microscopy combined with functional studies to reveal how #augmin ensures proper chromosome attachments to the spindle microtubules. @institutrb @hrzz_science
https://t.co/TT4OxC2GYW
We propose that mutations in #augmin and #gammaTuRC subunits that have been linked to human developmental disorders may not only affect #microtubule nucleation, but could also impair centriole integrity, which Nina found to interfere with #ciliogenesis. 5/n
๐งฌ#Augmin is a large protein complex that was previously known to amplify #microtubule formation. The new findings identify it as pivotal for this key cellular process. When inactivated in the developing brain of mouse embryos, brain development stops & embryos die before birth.
In summary, #spindle #chirality depends on spindle shape, external forces, and on #motors (#Eg5, #Kif18A) that rotate #microtubules within the antiparallel overlaps. #PRC1 contributes to chirality by limiting microtubule rotation, and #augmin by nucleating bridging microtubules.
More news about #augmin from the @LudersLab ! Here Ricardo Viais explores its role in brain development!
https://t.co/rGRDiGzJR3
Another @LudersLab preprint!
Ricardo Viais tested the requirement for #augmin-mediated #microtubule amplification in vivo, by knockout in mouse neural progenitors during brain development. In contrast to #centrosomes, augmin is essential!
https://t.co/p2I4W5xCS9
New @LudersLab preprint! @schweizer_nina, with help from the Merdes lab, used expansion microscopy #ExM to identify a non-canonical role of #augmin and the #microtubule nucleator #gammaTuRC as part of a stabilizing scaffold in the centriole lumen.
https://t.co/yBhfEvrJFf
After #HAUS8 knock-out, #kinetochore fibers lacking a bridging fiber are straight, resulting in a diamond-like shape of the #spindle. Thus, compression in the #augmin-generated bridging fibers keeps the spindle round. Thanks to @iaincheeseman for the #CRISPR knock-out cell line!
In #augmin-depleted cells, the interkinetochore distance decreases preferentially for #kinetochores that lack a bridging fiber, independently of the thickness of their k-fibers, implying that #augmin affects #forces on #kinetochores largely via bridging fibers.
After @JurajSimunic and Martina observed the hollow barrel configuration of #augmin-depleted #spindles, @StimacV and @isabella__k pushed the limits of image analysis to quantify the effects of bridging fiber absence on #metaphase spindles and especially on #kinetochores.
Hello #spindle lovers! In our new #bioRxiv #preprint we find that #augmin is a major contributor to the nucleation of bridging #microtubules. We propose that these microtubules slide apart, which promotes poleward flux of kinetochore fibers and tension on #kinetochores.
Excited to be part of this special selection with our work on #augmin and #branchingmicrotubulenucleation from @LabPetry
Read a special selection of research advancing our understanding of cell division in health and disease, recently published in JCB https://t.co/qQC8aWQtZp
Fully purified #nucleator (g-TuRC, 2.5 MDa with about 30 proteins), eight-subunit #augmin complex and the protein #TPX2. Ray attempted this with different approaches over many years. It required first getting to know each individual component in depth (published over last years).
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