Top Tweets for #dendritic_cells
#cancer #immunotherapy #T_cells #dendritic_cells
🦉 The most interesting result here is that dendritic-cell identity may matter less than dendritic-cell state.
In mouse tumors, neither cDC1 nor cDC2 was automatically an effective T-cell activator.
Tumor-specific CTL stimulation was concentrated in a CCR7+ activated state—and deleting these actDCs weakened spontaneous tumor control, checkpoint blockade and adoptive T-cell therapy.
There is a mechanistic twist. cDC1-derived actDCs primed CTLs through classical cross-presentation, while cDC2-derived actDCs could contribute through “cross-dressing”: acquiring intact peptide–MHC complexes from other cells rather than processing antigen themselves.
That gives cDC2s a more direct antitumor role than the usual cDC1-centric model suggests, although this route depended on tumor type.
The broader implication is useful for drug development: simply expanding dendritic cells may be the wrong goal.
Therapies may need to push them into—and maintain—the right functional state.
The major caveat is equally clear: this is compelling genetic evidence in mice, not yet proof that manipulating CCR7+ actDCs will improve human immunotherapy.
👁️CCR7+ activated dendritic cells are essential for spontaneous and immunotherapy-driven anti-tumor immunity.
👉https://t.co/dxH6abkOAB
#oncology #immunotherapy #T_cell #Dendritic_cells #China
$NWBO
🦉 A useful shift in thinking: resistance to immunotherapy may begin before the T cell ever sees the tumor.
This review argues that dysfunctional antigen-presenting cells—especially dendritic cells—can be an upstream bottleneck.
Tumors can exclude cross-presenting cDC1s through β-catenin signaling, suppress DC maturation via STAT3 and VEGF, and use hypoxia, lactate, adenosine and tryptophan metabolism to push remaining APCs toward tolerance.
The result is important: a tumor may contain recognizable antigens yet fail to generate the T cells that checkpoint inhibitors need to rescue.
That reframes some “checkpoint-resistant” cancers.
Simply adding more antigen or blocking another inhibitory receptor may accomplish little if the antigen-presentation machinery is functionally absent.
A more rational strategy could be to rebuild the APC→T-cell axis first—recruit the right DC subset, restore cross-presentation and maturation, then release T-cell inhibition.
The implication extends well beyond DC vaccines: in some cold tumors, the critical therapeutic target may be the immune response’s ignition system, not its brakes.
https://t.co/twKzKOhvu8
Postdoctoral Associate @csgarrix
The Garris lab at MGH is looking for a postdoc to develop myeloid-oriented cancer therapeutics leveraging myeloid: T cell crosstalk.
https://t.co/WNmp3fOEk9
#cancer_biology #cancer_immunology #dendritic_cells #immunol...
https://t.co/WNmp3fOEk9
Continuing with very open discussions at the #EMDS2023 with @ReiseSousaLab showing incredibly interesting DC receptors and cancer @VIBConferences #Dendritic_cells
Way to go, #Dendritic_cells💪🏻, #DC, in love 😍 to play with #T_cells at different levels in the context of “crosstalk” to shape two T cell-associated checkpoints in #antitumor_immunity. More of this can be found @ImmunityCP.
#immunity
#immune_crosstalk
#cancer
#CancerResearch
https://t.co/UJMPvHZTFp
Way to go, #Dendritic_cells!
A newly published review article @ImmunityCP summarized the five key activities in DCs that are needed to stimulate new and long-lived antigen-specific T-cell responses. Can't wait to see #DC’ further investigations 😎
#immunity
#innate_immunity
#CancerResearch
#immunotherapy
https://t.co/hcibrOY6EU
#MyeSOP and #MyeDisease joined forces to explore inter-WG collaboration with a cell type-specific focus at @MyeInfoBank @COSTprogramme. #Macrophages #Neutrophils #Dendritic_cells were under the discussion.
"Concomitant inhibition of PPARγ and mTORC1 induces the differentiation of human monocytes into highly immunogenic dendritic cells" #Dendritic_Cells
Clinical grade adjuvants to mature CD141+ DCs for immunotherapy
from @unav
👉https://t.co/wZzsN9BTw4
#Dendritic_cells #immunotherapy #cancer #RNA #PCoA #cytokines #immune
Have a chat with Marcel Marson from our lab at his poster P-0021 #ECI2021 on novel function of the #tetraspanin Tspan2 on #neutrophils and #dendritic_cells. He's happy to discuss his recent results with you.
Characterisation of human intestinal #macrophages and #dendritic_cells. Delighted to have been involved with this study led by @FentonThomas and @williamagace.
Reassured to see the #monocyte 'waterfall' in the human gut! 😉
@socmucimm @britsocimm @EdinUni_MeetCIR
while the focus here is on viral immunity, I think this Fc-hacking is useful in anti-tumor #immunotherapy via #dendritic_cells.
from the Ravetch lab @RockefellerUniv and @Vir_Biotech
https://t.co/wBEuaS4JcE
#Unresponsiveness to #Inhaled_Antigen | governed by conventional #Dendritic_Cells and overridden during infection by #Monocytes | Linda Wakim @TheDohertyInst @SciImmunology https://t.co/6pVn15BWuo
#Unresponsiveness to #Inhaled_Antigen | governed by conventional #Dendritic_Cells and overridden during infection by #Monocytes | Linda Wakim @TheDohertyInst @SciImmunology https://t.co/6pVn15BWuo
#Unresponsiveness to #Inhaled_Antigen | governed by conventional #Dendritic_Cells and overridden during infection by #Monocytes | Linda Wakim @TheDohertyInst @SciImmunology https://t.co/6pVn15BWuo
Fantastic talk by @ASImmunology visiting speaker @ProfAndrewMac from @OfficialUoM on the role of #dendritic_cells and #macrophages in type2 #inflammation #allergy @CCSMonash. Next stop is @Malaghan_Inst
#mdpicells Metabolic Stress in the Immune Function of T Cells, Macrophages and Dendritic Cells https://t.co/mbTGQCjbTT #T_cells #Macrophages #dendritic_cells #immunology @MDPIOpenAccess
Interested in phagocytosis? Our latest paper:
https://t.co/hk0yTF86fm
#phagocytosis #dendritic_cells #actin #SWAP70 #rac1 #smallGTPases
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