Top Tweets for #hostdirectedtherapy
π«π¬ Researcher at @IpbsToulouse unlock new insights into cystic fibrosis-related lung infections: Human airway organoids reveal potential host-directed strategy to combat Mycobacterium abscessus: https://t.co/A3mFkh12fJ
#CysticFibrosis #LungInfections #HostDirectedTherapy

π«π¬ Researcher at @IpbsToulouse unlock new insights into cystic fibrosis-related lung infections: Human airway organoids reveal potential host-directed strategy to combat Mycobacterium abscessus: https://t.co/A3mFkh12fJ
#CysticFibrosis #LungInfections #HostDirectedTherapy

New preprint! #Mycobacterium #tuberculosis alters host #immunometabolism by limiting myeloid-cell glycolysis via depletion of NAD(H). Our study proposes nicotinamide as a potential #HostDirectedTherapy against #TB. Congratulations @hayden_pacl & teamπ @AHRI_News @UABMicrobiology
My dissertation work from @SteynTBLab is out as a #preprint! We show 1) glycolytic myeloid cells protect the host in #tuberculosis, 2) Mtb limits glycolysis in myeloid cells by depleting NAD(H), and 3) nicotinamide counters this and works as a TB drug! https://t.co/hswJsBzsfH
Can we flip our thinking on #drugresistance & #antibioticresistance - instead of targeting pathogens directly, target the human enzymes required for their survival?
New review on #hostdirectedtherapy in @CellRepMed from RMIT's Christian Doerig & team: https://t.co/icCt0OKsKj

Imatinib augments standard malaria combination therapy without added toxicity
@JExpMed #hostdirectedtherapy #malaria
https://t.co/0XvIV6go2g
Latest review from #SteynLab. #HemeOxygenase1 as a pharmacological target for #HostDirectedTherapy to limit #tuberculosis associated #immunopathology
Congratulations, everyone!!ππ¨βπ¬π¦ π¬
@hayden_pacl @anupamuab @UABMicrobiology @AHRI_News @antioxidants_OA https://t.co/NDmjK8xdbo
Part 2 of pandemic review pandemonium! Congrats to lead author @Krishna4Science and mentors Steyn and @anupamuab: HO-1 as a Target for Host-Directed Therapy to Limit #Tuberculosis Immunopathology #mdpiantioxidants via @MDPIOpenAccess @UABMicrobiology https://t.co/lmBEceMfeS
Interested in how bacterial #pathogens mimic host #SLiMs? Then try a recent Review by @hugocarlos__ and Toby Gibson #embl for your #ScienceFriday #FridayReads!
#molecularmimicry #hostdirectedtherapy #drugrepurposing
https://t.co/tEv2iAjlfT

Check out a new Review online - "Mimicry of Short Linear Motifs by Bacterial Pathogens: A Drugging Opportunity" by @hugocarlos__ and Toby Gibson @embl.
#SLiMs #hostdirectedtherapy #drugrepurposing
https://t.co/yuaqXbmNOH

This may seem a niche issue in management of #COVID19 at present, but patients that deteriorate later in their course of illness, a deleterious immune response, rather than uncontrolled viral replication, may be driving pathology and symptoms. #hostdirectedtherapy
π¨Immune landscape by single sequencing of BAL cells in patients with mild & severe #COVID19π¨
Detailed analysis within this pre-print. And although clearly confounded by disease severity, some support for the role of immunopathology in severe disease.
https://t.co/ik0uPF0H5k

Jessica Haughen from @TBRU_LIMAA presents the influence of #metformin treatment in a guinea pig model on T cell differentiation and host resistance to mycobacterium tuberculosis at the @NIH TBRU-N annual meeting #TB #hostdirectedtherapy #Metabolism #immunology @megan_b_murray

@A_P_S_A Hey all, I'm a GS2 at UAB! I study #immunometabolism in #TB through the characterization of targets for novel TB drugs that enhance the host response. #HostDirectedTherapy #Neutrophils #DoubleDocs. I am also a penpal for @LettersPreSci, and you should be too!
#UAB research finding may point to a therapeutic target to treat #tuberculosis, which kills 1.3 million people each year. https://t.co/MOGiHxai0A

Brendan Podell from @TBRU_LIMAA presents progress on developing a #guineapig model to study the interaction between #tuberculosis and #diabetes and #metabolism to discover potential #hostdirectedtherapy for TB. @NIH @NIAIDNews

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