Top Tweets for #hras
Static #HRAs can limit completion. See how #AIagents create a more adaptive digital experience that helps members participate and connects responses to personalized care plans and next steps: https://t.co/ZOgta9YJCU #AI #AI #EnterpriseAI #Healthtech #memberexperience
🔥Hot off the press | Overcoming resistance to RAS #MolecularGlues
#RAS (#KRAS/ #NRAS/ #HRAS) mutations drive many cancers by locking signaling in an “always-on” state. New tri-complex inhibitors (TCIs), like daraxonrasib, recruit CYPA to block RAS–RAF signaling—but resistance is already emerging.
A Cell study of 40 patients reveals two key escape routes.
🧪 KRAS mutations
KRAS Y64 variants weaken drug binding and disrupt complex formation. KRAS Y71 mutations instead strengthen RAS–RAF interaction, competing against the drug effect.
🧬 BRAF alterations
Kinase-dead or low-activity BRAF mutants stabilize RAF dimers, sustaining downstream signaling even under treatment.
🔁 Overall, resistance converges on restoring RAS–RAF signaling—either by weakening drug binding or strengthening native protein interactions. The study also suggests potential fixes, including next-gen inhibitors like #RMC4791 and combination strategies targeting RAF dimers or MEK/ERK signaling. A clearer roadmap for designing more durable molecular glues. https://t.co/QdJQ3bEF7p
MedChemExpress provides #Elironrasib, an orally active covalent KRAS inhibitor, supporting this research, along with a wide range of molecular glues and compound libraries—your trusted partner in scientific discovery. https://t.co/SqCXwHVv7s
#CancerResearch #DrugResistance #TargetedTherapy #Oncology
Safety, Efficacy, and On-Treatment Circulating Tumor DNA (ctDNA) Changes from a Phase 1 of Daraxonrasib (RMC-6236), a RAS(ON) Multi-Selective, Tri-Complex Inhibitor, in Patients with RAS Mutant PDAC $RVMD #GI25 #ASCOGI25 #KRAS #NRAS #HRAS
DCO 23 Jul 2024 as prev. presented @ #ENA24 as well, only the ctDNA data are new if I'm mistaken
https://t.co/595L5P2CEB
الروبوت زومبا أول موظف خدمة عملاء لدى شركة إبداع وطن شاركت زومبا بقوة
#بملتقى_ومعرض_الموارد_البشرية_والقوي_العاملة
@Rals2030 @ebdae94 #HRAS #HRAS_EXPO #riyadh
للتواصل مع شركة AB ROBOTS عن طريق رقم
00966566033530 📞 أو عن طريق https://t.co/9zyFDLn7l4
#السعودية #الرياض
الروبوت زومبا، أول موظف خدمة عملاء لدى شركة إبداع وطن ، متوفر للإيجار أو الشراء في المملكة.@Rals2030 @ebdae94
#ملتقي_ومعرض_الموارد_البشرية_والقوي_العاملة
#الرياض
#HRAS
#HRAS_EXPO
#riyadh
للتواصل مع شركة AB ROBOTS عن طريق رقم
00966566033530 📞 أو عن طريق https://t.co/9zyFDLn7l4
Online now - the Spotlight "Two hearts beat as one: the debate over #RAS dimers continues" from Andrew Stephen @theNCI.
#KRAS #NRAS #HRAS #nanocluster #RAFkinase #nativemassspectrometry #liposomes
Read it here 👉 https://t.co/1555aDjrxG
Preprint @CirsteaLab @MEL_GLER impaired MC3T3 preosteoblasts osteogenesis by #oncogenic #HRAS G12S and G12V mutants is rescued by #Tipifarnib only in G12S-expressing cells. #osteopontin #CostelloSyndrome
https://t.co/9eXEv4a5a6
A #preprint from @CirsteaLab on @researchsquare: Impaired MC3T3-E1 #osteoblast differentiation triggered by #oncogenic #HRAS is rescued by the FTI #Tipifarnib #osteopontin https://t.co/unkq2x8fwo
#CostelloSyndrome
@KopsLab @kazu_maeshima shares his lab's beautiful work on chromatin reorganization after #HRAS transformation Chromatin organization and behavior in HRAS-transformed mouse fibroblasts | Chromosoma (https://t.co/QEZX2h0Fr2)
Congratulations to the team! @SamuelKareffMD @AsaadTrabolsi @Latinamd @COlazagasti @GlopesMd ! #HRAS mutations - pan-Tumor analysis in solid tumors.
Our Cape Town team out in Protea Park (Atlantis) conducting health risk assessments.❤🧠
#hearthealth #brainhealth #hras #HSFSA
By re-analyzing the publicly available #HRAS WT vs. G12D interactomes, we specifically identify the positive control LVVVGAGGVGK peptidoforms in its mutated and WT state among the most significant hits of our analysis.
Today #CorcoranLab together with @Labrat3 and @andrewaguirremd @DanaFarber presents "One for all and all for one: Repurposing KRASG12C inhibitors to target all RASG12C isoforms"
@MGHCancerCenter @harvardmed @CD_AACR #Sotorasib #NRAS #HRAS #crcsm #GITwitter
https://t.co/pT4CvAc3bp
📢 Our latest publication explores the performance of HRAS pilot plant, unveiling its potential for energy-efficient #wastewater treatment 🌿💧 Dive into insights on nutrient removal and COD harvesting as sustainable solutions #ChemicalEngineering #HRAS
New paper @LEQUIA_UdG @GsInima Nutrients removal by high-rate activated sludge and its effects on the mainstream wastewater treatment https://t.co/ILzg2ZyS8w
We’re presenting data from our registration-directed AIM-HN study of #tipifarnib in patients with #HRAS mutant head and neck squamous cell carcinoma (#HNSCC) in a late-breaking oral session, this Saturday at #ESMO23. View the press release here: https://t.co/AtIwAPCVBF @myESMO
🎈 SLAVÍME 30 LET!!! 🎈
Pojďte to oslavit s námi a zahrát si pár her v krásných prostorách Karlínského Spektra.
Těšíme se na vás v sobotu 30. 9. od 13 hodin v DDM Spektrum na Karlínském náměstí 7.
https://t.co/zUxRU06z1B
#hras #hrascz #30let #hrascon #ddmspektrum
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