Top Tweets for #inavo120
⭐️ #SABCS25 Insights on advancing HR+ breast cancer treatment! 🚀
#INAVO120->inavolisib to palbo + fulvestrant as 1L therapy ⬆️ OS (34 vs 27 mo) in PIK3CA-mutated, HR+/HER2- aBC
#bcsm #OncTwitter @SPremji7866 @SarahCannonDocs @WinshipAtEmory
Full 🗣️⬇️
https://t.co/DNze3Gteih
4️⃣ #INAVO120 : Ph III trial showing ⬆️OS for INAVO+PALBO+Fulvestrant in PIK3CA-mutated, endocrine-resistant advanced BC
⬆️OS: 34 vs 27 months (HR 0.67)
⬆️ mPFS 17.2m vs 7.3m
‼️ORR 62.7% vs 28%
❌new safety concerns
#MedTwitter #bcsm #MedX #BreastCancer #CommunityOncology
🚨Missed @ASCO 🤔, we got you covered!!
#ASCO2025 recap series: Breast Cancer ⬇️
1️⃣ #DESTINYBreast09
2️⃣ #SERENA-6
3️⃣ #ASCENT-04/#KEYNOTE-D19
4️⃣ #INAVO120
5️⃣ #VERITAC-2
6️⃣ #neoCARHP
7️⃣#NeoSTAR
#Medtwitter #MedX #OncTwitter #CancerResearch #Oncology #CommunityOncology #bcsm
Part 4: #ASCO25 recap series
4️⃣ #INAVO120 : Ph III trial showing ⬆️OS for INAVO+PALBO+Fulvestrant in PIK3CA-mutated, endocrine-resistant advanced BC
⬆️OS: 34 vs 27 months (HR 0.67)
⬆️ mPFS 17.2m vs 7.3m
‼️ORR 62.7% vs 28%
❌new safety concerns
#MedTwitter #OncTwitter #bcsm
European Commission approves Roche’s Itovebi for people with ER-positive, HER2-negative, advanced breast cancer with a PIK3CA mutation.
https://t.co/EbXoB8Dl0v
#LARVOL #CancerResearch #Oncology #ClinicalTrials #CancerData #OncologyInsights
#BreastCancer #INAVO120
Learn more about INAVO120 (NCT04191499) 👉 https://t.co/fhAveCuSJT
Breast Cancer Highlights from #ASCO25 w/ @ErikaHamilton9
✅ #INAVO120
✅ #SERENA6
✅ #VERITCA2
✅ #DESTINYBreast09
✅ #ASCENT04
Full Discussion:
- https://t.co/96dmdcgTAg
- Also on the “Oncology Brothers” podcast
#bcsm @ASCO #OncTwitter #MedTwitter
Representation in clinical trials is a critical scientific focus needed to address this! How does a phase III trial #INAVO120 testing a drug commonly associated with hyperglycemia as a side effect, only enroll 0.6% Blacks? #ASCO25 #asco2025 @WinnAwards
📈 New 1st-line standard for PIK3CA-mutant HR+/HER2– breast cancer? #ASCO25
#INAVO120 shows that inavolisib + palbociclib + fulvestrant
⌛ Chemo delayed ~2 yrs
📄 Simultaneously in @NEJM:
🔗 https://t.co/FJK313lp38
👇
@OncoAlert @ASCO @CParkMD @crisbergerot @NazliDizman
@VivekSubbiah @montypal @OncBrothers @TwoOncDocs @OncLive
@Larvol @ONCOassist @yekeduz_emre @DrYukselUrun
2. #INAVO120: Ph III, Inavolisib (iPI3Ka) + Fulv + Palbo vs Palbo/Fulvestrant HR+ metastatic breast cancer:
- mOS 34.0 vs 27.0 mos (HR 0.67). First to show OS as a PIK3/AKTi
- mPFS 17.2 vs 7.3mos (HR 0.42)
- AEs: >50% hyperglycemia & stomatitis
3/8
INAVO120 OS benefit published in @NEJM: 34 months with inavolisib vs 27 months w placebo (HR 0.67). Objective response 62.7% vs 28%. Incredible results and 7 month OS benefit👏👏👏 @jhaveri_komal https://t.co/z4sbCUBbaL #bcsm #ASCO25
Presentados en el #ASCO25 y publicados en @NEJM, los resultados de #INAVO120 — con @CristinaSaura3 en el comité directivo — muestran que inavolisib, combinado con la terapia estándar, mejora los resultados en el cáncer de mama avanzado con mutación en PIK3CA.
👉 https://t.co/HmoJheJc6x
#MamaVHIO @ASCO
NEW research summary from #ASCO25: Adding inavolisib to palbociclib and fulvestrant can help patients with PIK3CA-mutated, HR+, HER2- advanced #BreastCancer live longer: https://t.co/Xph4y0e7RO
#BCSM #INAVO120
📣 Afegir un nou fàrmac a la combinació estàndard millora la supervivència en pacients amb #càncer de mama metastàtic amb mutacions en el gen PIK3CA.
Els resultats de l'assaig clínic de fase 3 #INAVO120 es presenten al congrés d'@ASCO que se celebra a Chicago. La Dra. Cristina Saura, cap de la Unitat de Càncer de Mama del Servei d’Oncologia Mèdica de #VallHebron i investigadora principal del Grup de Càncer de Mama i Melanoma del @VHIO és coautora de l'estudi.
Llegeix la notícia 👉 https://t.co/3opSbd9Ndn
Presentados en el #ASCO25 y publicados en @NEJM, los resultados de #INAVO120 — con @CristinaSaura3 en el comité directivo — muestran que inavolisib, combinado con la terapia estándar, mejora los resultados en el cáncer de mama avanzado con mutación en PIK3CA.
👉 https://t.co/HmoJheJc6x
#MamaVHIO @ASCO
Presented at #ASCO25 and published in @NEJM, the results of the #INAVO120 trial — with @CristinaSaura3 on the steering committee — show that inavolisib combined with standard therapy improves outcomes in PIK3CA-mutated advanced #BreastCancer.
👉 https://t.co/H9UjW54LOp
@ASCO #MamaVHIO
🔥 Big Win in HR+/HER2– Breast Cancer!
Final #INAVO120 results at #ASCO25 show OS benefit with INAVO + PALBO + Fulvestrant in PIK3CA-mutated, endocrine-resistant ABC:
✅ OS: 34.0 vs 27.0 mo
✅ HR 0.67 | p = 0.019
✅ INV-PFS: 17.2 vs 7.3 mo
✅ ORR: 62.7% vs 28%
✅ TTC delay: ~2 years!
⚠️ Hyperglycemia (G1–4): 63%
❌ No new safety signals
🧬 Durable, clinically meaningful benefit
💊 Precision therapy with a price: glucose checks!
#BreastCancer #OncoTwitter #PrecisionOncology #PIK3CA @ASCO #ASCO25 @OncoAlert
Oncologist buzz on X (formerly Twitter) with Roche's release for INAVO120 trial - Roche’s Itovebi demonstrated statistically significant and clinically meaningful overall survival benefit in a certain type of HR-positive advanced #breastcancer.
#LARVOL #CancerResearch #Oncology #OncologyInsights #INAVO120
🗞️ Esta semana hemos sabido que los resultados del ensayo clínico de fase 3 #INAVO120 muestran que añadir un inhibidor de PI3K mejora los resultados en pacientes con #CáncerDeMama metastásico que presentan esta mutación.
➡️ https://t.co/PWkCeQYF1z
#MamaVHIO
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